| Topo II Inhibitor Sensitivity Marker | ||||
|---|---|---|---|---|
| Marker | Name | Biological Role | Evidence | References |
| TOP2A | Topoisomerase 2, alpha | Enzyme unwinds supercoiled DNA to permit strand separation required for DNA synthesis and transcription | High expression correlated with good responses to doxorubicin and etoposide in ovarian cancer | TopoII Inhibitor Sensitivity: Top2A References |
