| 5-FU Resistance Marker | ||||
|---|---|---|---|---|
| Marker | Name | Biological Role | Evidence | References |
| TS | Thymidylate synthase | Synthesizes dTMP required for DNA synthesis | High TS protein levels correlate with poor efficacy and survival in colorectal, gastric, and esophageal cancer treated with 5-fluorouracil-based therapies | 5-FU Resistance Marker: TS References |
