| Pemetrexed Resistance Marker | ||||
|---|---|---|---|---|
| Marker | Name | Biological Role | Evidence | References |
| TS | Thymidylate synthase | Synthesizes dTMP required for DNA synthesis | High TS expression correlated with poor efficacy and outcome in NSCLC and mesothelioma patients treated with pemetrexed-based therapy | Pemetrexed Resistance: TS References |
