Gemcitabine Resistance Markers
|
Marker | Name | Biological Role | Evidence | References |
RRM1 |
ribonucleotide reductase, regulatory subunit M1 |
Enzyme synthesizes deoxyribonuceosides from ribonucleoside precursors |
High mRNA and protein levels associated with poor response and outcome in pancreatic, biliary, and NSCLC patients after gemcitabine-based therapy |
Gemcitabine Resistance: RRM1 References |
RRM2 |
ribonucleotide reductase, regulatory subunit M2 |
Enzyme synthesizes deoxyribonuceosides from ribonucleoside precursors |
High mRNA expression correlated with poor outcome following gemcitabine treatment in pancreatic, NSCL, and ovarian cancer |
Gemcitabine Resistance: RRM2 References |