| Gemcitabine Resistance Markers | ||||
|---|---|---|---|---|
| Marker | Name | Biological Role | Evidence | References |
| RRM1 | ribonucleotide reductase, regulatory subunit M1 | Enzyme synthesizes deoxyribonuceosides from ribonucleoside precursors | High mRNA and protein levels associated with poor response and outcome in pancreatic, biliary, and NSCLC patients after gemcitabine-based therapy | Gemcitabine Resistance: RRM1 References |
| RRM2 | ribonucleotide reductase, regulatory subunit M2 | Enzyme synthesizes deoxyribonuceosides from ribonucleoside precursors | High mRNA expression correlated with poor outcome following gemcitabine treatment in pancreatic, NSCL, and ovarian cancer | Gemcitabine Resistance: RRM2 References |
