Capecitabine Resistance Markers

Capecitabine Resistance Marker
Marker Name Biological Role Evidence References
EGFR Epidermal growth factor receptor Receptor tyrosine kinase that binds EGF and activates intracellular signaling to enhance cell growth High expression correlated with poor response to neoadjuvant therapy in colorectal cancer patients Capecitabine Resistance: EGFR References
DPD Dihydropyrimidine dehydrogenase Catabolizes 5FU to inactive metabolite High levels of DPD relative to TP associated with poor response or outcome in capecitabine-treated patients Capecitabine Resistance: DPD References