| Capecitabine Resistance Marker | ||||
|---|---|---|---|---|
| Marker | Name | Biological Role | Evidence | References |
| EGFR | Epidermal growth factor receptor | Receptor tyrosine kinase that binds EGF and activates intracellular signaling to enhance cell growth | High expression correlated with poor response to neoadjuvant therapy in colorectal cancer patients | Capecitabine Resistance: EGFR References |
| DPD | Dihydropyrimidine dehydrogenase | Catabolizes 5FU to inactive metabolite | High levels of DPD relative to TP associated with poor response or outcome in capecitabine-treated patients | Capecitabine Resistance: DPD References |
