| Taxane Sensitivity Marker | ||||
|---|---|---|---|---|
| Marker | Name | Biological Role | Evidence | References |
| BRCA1 | Breast cancer 1 (Breast and ovarian cancer susceptibility gene) | DNA repair (Homologous recombination-- double strand break repair) | High mRNA expression correlated with good response and outcomes following taxane-based treatment in ovarian and NSCLC | Taxane Sensitivity: BRCA1 References |
| TLE3 | Transducin-like enhancer of split 3 | Transcriptional co-repressor protein that interacts with other transcription factors to block gene expression | High protein levels correlate with good outcome in taxane-treated endometrioid, mucinous, and clear cell ovarian and triple negative breast cancer patients | Taxane Sensitivity: TLE3 References |
| SPARC | Secreted protein, acidic, cysteine-rich (osteonectin) | matrix-associated protein that modulates cell shape, cell proliferation, extracellular matrix production | High protein expression correlated with good response in head & neck cancers | Nab-paclitaxel Sensitivity: SPARC Reference |
