Taxane Resistance Markers |
Marker | Name | Biological Role | Evidence | References |
TUBB3 | Tubulin beta III subunit | Beta-tubulin family member that heterodimerizes with alpha-tubulins to form cellular microtubules | Elevated protein and mRNA expression correlated with taxane resistance and poor prognosis in ovarian cancer patients | Taxane Resistance:
TUBB3 References |
PGP
(MDR1, ABCB1) | P-Glycoprotein; multi-drug resistance protein 1
| ATP-binding cassette transporter and drug efflux pump for paclitaxel and docetaxel
| High mRNA and protein expression associated with poor responses and outcomes to paclitaxel therapy in ovarian cancer | Taxane Resistance:
PGP References |
ER | Estrogen receptor | Estrogen-activated transcription factor that induces expression of cell cycle and anti-apoptotic genes | Expression correlated with poor responses to neo-adjuvant taxane therapy in breast cancer | Taxane Resistance:
ER References
|
Survivin
(BIRC5) | baculoviral IAP repeat containing 5 | Inhibitor of apoptosis that is also important for cell cycle transit through G2/M | High protein and mRNA expression associated with taxol resistance in ovarian cancer | Taxane Resistance: Survivin References
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