| Taxane Resistance Markers | ||||
|---|---|---|---|---|
| Marker | Name | Biological Role | Evidence | References |
| TUBB3 | Tubulin beta III subunit | Beta-tubulin family member that heterodimerizes with alpha-tubulins to form cellular microtubules | Elevated protein and mRNA expression correlated with taxane resistance and poor prognosis in ovarian cancer patients | Taxane Resistance: TUBB3 References |
| PGP (MDR1, ABCB1) | P-Glycoprotein; multi-drug resistance protein 1 | ATP-binding cassette transporter and drug efflux pump for paclitaxel and docetaxel | High mRNA and protein expression associated with poor responses and outcomes to paclitaxel therapy in ovarian cancer | Taxane Resistance: PGP References |
| ER | Estrogen receptor | Estrogen-activated transcription factor that induces expression of cell cycle and anti-apoptotic genes | Expression correlated with poor responses to neo-adjuvant taxane therapy in breast cancer | Taxane Resistance: ER References |
| Survivin (BIRC5) | baculoviral IAP repeat containing 5 | Inhibitor of apoptosis that is also important for cell cycle transit through G2/M | High protein and mRNA expression associated with taxol resistance in ovarian cancer | Taxane Resistance: Survivin References |
