Taxane Resistance Markers

Taxane Resistance Markers
Marker Name Biological Role Evidence References
TUBB3 Tubulin beta III subunit Beta-tubulin family member that heterodimerizes with alpha-tubulins to form cellular microtubules Elevated protein and mRNA expression correlated with taxane resistance and poor prognosis in ovarian cancer patients Taxane Resistance: TUBB3 References
PGP (MDR1, ABCB1) P-Glycoprotein; multi-drug resistance protein 1 ATP-binding cassette transporter and drug efflux pump for paclitaxel and docetaxel High mRNA and protein expression associated with poor responses and outcomes to paclitaxel therapy in ovarian cancer Taxane Resistance: PGP References
ER Estrogen receptor Estrogen-activated transcription factor that induces expression of cell cycle and anti-apoptotic genes Expression correlated with poor responses to neo-adjuvant taxane therapy in breast cancer Taxane Resistance: ER References
Survivin (BIRC5) baculoviral IAP repeat containing 5 Inhibitor of apoptosis that is also important for cell cycle transit through G2/M High protein and mRNA expression associated with taxol resistance in ovarian cancer Taxane Resistance: Survivin References