| Capecitabine Sensitivity Markers | ||||
|---|---|---|---|---|
| Marker | Name | Biological Role | Evidence | References |
| TS | Thymidylate synthase | Synthesizes dTMP required for DNA synthesis | High TS expression correlated with good responses and outcome in rectal, breast, and esophageal cancer patients treated with capecitabine | Capecitabine Sensitivity: TS References |
| TP | Thymidine phosphorylase | Generates 5FU from pro-drug | High TP protein expression or high ratio of TP to DPD associated with good response in colorectal, esophageal, lung, and breast cancer patients following capecitabine therapy | Capecitabine Sensitivity: TP and TP/DPD ratio References |
