Platinum Sensitivity Markers

Platinum Sensitivity Markers
Marker Name Biological Role Evidence References
Breast cancer 1 (Breast and ovarian cancer susceptibility gene) DNA repair (Homologous recombination-- double strand break repair) Germline mutations that result in inactivated BRCA1 associate with platinum sensitivity in ovarian cancer Platinum Sensitivity: BRCA1 References
p21 Cyclin-dependent kinase inhibitor 1A Mediates arrest in G1 phase of cell cycle High protein expression is correlated with good response and increased survival with platinum-based therapy in ovarian cancer Platinum sensitivity: p21 References