| Platinum Sensitivity Markers | ||||
|---|---|---|---|---|
| Marker | Name | Biological Role | Evidence | References |
| BRCA1 mutation | Breast cancer 1 (Breast and ovarian cancer susceptibility gene) | DNA repair (Homologous recombination-- double strand break repair) | Germline mutations that result in inactivated BRCA1 associate with platinum sensitivity in ovarian cancer | Platinum Sensitivity: BRCA1 References |
| p21 | Cyclin-dependent kinase inhibitor 1A | Mediates arrest in G1 phase of cell cycle | High protein expression is correlated with good response and increased survival with platinum-based therapy in ovarian cancer | Platinum sensitivity: p21 References |
