| Gemcitabine Sensitivity Markers | ||||
|---|---|---|---|---|
| Marker | Name | Biological Role | Evidence | References |
| ENT1 | Equilibrative nucleoside transporter | Membrane protein that transports nucleosides (and nucleoside analogs like gemcitabine) into cell | High protein expression associated with increased response rates and longer survival in gemcitabine-treated pancreatic, biliary, and bladder carcinoma patients | Gemcitabine Sensitivity: ENT1 References |
| DCK | Deoxycytidine kinase | Enzyme phosphorylates deoxycytidine (and gemcitabine) to mono-phosphate deriviative that is sequentially phosphorylated to the di- and tri-phosphate active drugs | High mRNA and protein expression associated with good responses and outcome in pancreatic cancer patients treated with gemcitabine | Gemcitabine Sensitivity: DCK References |
| HuR (ELAVL1) | Human antigen R | Stress response RNA binding protein that regulates stability of genes involved in angiogenesis and proliferation | High levels correlated with gemcitabine efficacy and better prognosis in pancreatic cancer | Gemcitabine Sensitivity: HuR References |
