mTOR INHIBITORS SENSITIVITY MARKERS

mTOR Inhibitor Sensitivity Markers
Marker Name Biological Role Evidence References
PTEN Phosphatase and tensin homolog deleted on chromosome 10 PIP3 phosphatase that is a tumor suppressor that reverses the action of PI3 kinase, thereby reducing the activation of AKT and downstream signaling Loss of protein expression correlates with response in breast, ovary, and endometrial cancers mTOR inhibitor sensitivity: PTEN references
PIK3CA Phosphatidyl-inositol triphosphate kinase catalytic domain, alpha subunit Phosphorylates the lipid phosphate PIP2 to form PIP3 which attracts signaling proteins to the membrane, where they are able to activate other downstream effectors, e.g., PDK and AKT Activating mutations in the PIK3CA gene correlate with temsirolimus response in breast, ovary, and endometrial cancers mTOR inhibitor sensitivity: PIK3CA references