| HER2 Inhibitor Sensitivity Markers | ||||
|---|---|---|---|---|
| Marker | Name | Biological Role | Evidence | References |
| HER2 (ErbB2) | Epidermal growth factor receptor type 2 | Membrane receptor tyrosine kinase that phosphorylates itself to initiates a cascade of signaling events that lead to increased cell proliferation and survival | Amplification of the HER2 gene is associated with trastuzumab response in ovarian and breast cancer High protein expression is correlated with good response in breast cancer |
HER2 inhibitor sensitivity: HER2 references |
