| mTOR Inhibitor Resistance Markers | ||||
|---|---|---|---|---|
| Marker | Name | Biological Role | Evidence | References |
| KRAS | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog | GTPase that relays signals from membrane receptors to downstream effectors (e.g., RAF kinase) to regulate cell proliferation and survival | Activating mutation in the KRAS gene is associated with poor outcome after everolimus treatment of endometrial and metastatic colorectal cancers that have PIK3CA mutation or absence of PTEN protein | mTOR inhibitor resistance: KRAS references |
