BRAF Inhibitors

BRAF Inhibitors Mechanism of Action
Vemurafenib Inhibits activated BRAF-driven cell proliferation, and survival by inhibiting the BRAF kinase activity
  1. Mutational activation of BRAF kinase stimulates the MAPK pathway without engagement of upstream growth factor receptors, such as EGFR, HER2, cMET, or IGF1R.

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Green squares, sensitivity markers. Red squares, resistance markers