| BRAF Inhibitors | Mechanism of Action |
|---|---|
| Vemurafenib | Inhibits activated BRAF-driven cell proliferation, and survival by inhibiting the BRAF kinase activity |
- Mutational activation of BRAF kinase stimulates the MAPK pathway without engagement of upstream growth factor receptors, such as EGFR, HER2, cMET, or IGF1R.
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Green squares, sensitivity markers. Red squares, resistance markers