cMET Inhibitors

cMET Inhibitors Mechanism of Action
Crizotinib, Cabozantinib Inhibits cMET-driven cell proliferation, invasion, and survival by inhibiting cMET receptor kinase activity
  1. Amplification of the cMET gene results in higher expression of the cMET protein and activation of downstream signaling through both RAS and PI3K pathways.

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Green squares, sensitivity markers. Red squares, resistance markers