| cMET Inhibitors | Mechanism of Action |
|---|---|
| Crizotinib, Cabozantinib | Inhibits cMET-driven cell proliferation, invasion, and survival by inhibiting cMET receptor kinase activity |
- Amplification of the cMET gene results in higher expression of the cMET protein and activation of downstream signaling through both RAS and PI3K pathways.
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Green squares, sensitivity markers. Red squares, resistance markers