| EGFR Inhibitor Sensitivity Markers | ||||
|---|---|---|---|---|
| Marker | Name | Biological Role | Evidence | References |
| EGFR MUT or AMP | epidermal growth factor (EGF) receptor | Membrane receptor tyrosine kinase activated by binding of EGF family ligands initiates a cascade of signaling events that lead to increased cell proliferation and survival | Activating mutations are correlated with response to gefitinib and erlotinib in ovarian cancer and NSCLC Increased EGFR gene copy number is associated with good response to cetuximab and erlotinib in lung and colorectal cancer |
EGFR inhibitor sensitivity: EGFR references |
