| Anti-estrogen, Aromatase Inhibitor, and Progestin Sensitivity Markers | ||||
|---|---|---|---|---|
| Marker | Name | Biological Role | Evidence | References |
| ER | Estrogen receptor, alpha | Estrogen-activated transcription factor that increases expression of genes involved in proliferation and survival | High protein expression is correlated with good response to tamoxifen, fulvestrant, letrozole, and anastrozole in ovarian cancer ER expression is correlated with response to MPA in ovarian cancer |
Anti-Estrogen and Aromatase inhibitor sensitivity:ER references Progestin sensitivity: PR reference |
| PR | Progesterone receptor | Progesterone-activated transcription factor that increases expression of genes involved in cellular differentiation and apoptosis | High protein expression is correlated with good response and increased survival following aromatase inhibitor treatment in breast cancer High protein expression is correlated with response to medroxy-progesterone acetate (MPA) in ovarian cancer |
Aromatase inhibitor sensitivity:PR reference Progestin sensitivity: PR reference |
