| NCT02855944 | III | Recurrent or progressive high grade serous or endometrioid ovarian cancer with BRCA1/2 mutations (>1 prior therapy) | ARIEL4 (Assessment of Rucaparib In Ovarian CancEr TriaL): A Phase 3 Multicenter, Randomized Study of Rucaparib Versus Chemotherapy in Patients With Relapsed, BRCA Mutant, High Grade Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer | View Drugs | Colorado, Georgia |
| Rucaparib | AG-014699, PF 01367338, CO-338, Rubraca | PARP inhibitor |
|
| NCT01851369 | II | Advanced solid tumors and granulosa cell ovarian cancer (in expansion) | A Phase I/II Trial of TRC102 (Methoxyamine HCl) in Combination With Temozolomide in Patients With Relapsed Solid Tumors and Lymphomas | View Drugs | Maryland |
| Methoxyamine | TRC102 | Base excision repair inhibitor | | Temozolomide | Temodal, Temodar, Methazolastone | DNA damaging agent |
|
| NCT02576444 | II | Advanced solid tumors with AKT, ARID1A, ATM, CDKN2A, CHEK2, IDH1/2, KRAS, MRE11A, PIK3CA, PTEN, TP53 and other HDR gene mutations | A Phase II Study of the PARP Inhibitor Olaparib (AZD2281) Alone and in Combination With AZD1775, AZD5363, or AZD6738 in Advanced Solid Tumors | View Drugs | Connecticut, Massachusetts, Ohio, Tennessee |
| Adavosertib | WEE1 inhibitor AZD1775, MK1775, AZD1775 | WEE1 inhibitor | | Capivasertib | Akt inhibitor AZD5363 | pan-AKT inhibitor | | Ceralasertib | AZD6738, ATR kinase inhibitor AZD6738 | ATR kinase inhibitor | | Olaparib | AZD2281, Lynparza | PARP inhibitor |
|
| NCT02832167 | II | Advanced solid tumors | An Open Label Phase 2 Multi-cohort Trial of Nivolumab in Advanced or Metastatic Malignancies | View Drugs | Arizona, California, Colorado, Florida, Illinois, Indiana, Maryland, Minnesota, Missouri, Nebraska, Nevada, New Jersey, New York, Oregon, South Carolina, Tennessee, Texas, Virginia |
| Nivolumab | BMS-936558, ONO-4538, MDX-1106, Anti-PD-1 human mab MDX-1106, Opdivo | Blocks PD-L1/2 inhibition of T cells |
|
| NCT02873962 | II | Platinum resistant or partially sensitive ovarian cancer | A Phase II Study With a Safety lead-in of Nivolumab in Combination With Bevacizumab or in Combination With Bevacizumab and Rucaparib for the Treatment of Relapsed Epithelial Ovarian, Fallopian Tube or Peritoneal Cancer | View Drugs | Massachusetts |
| Bevacizumab | immunoglobulin G1 (human-mouse monoclonal rhuMab-VEGF gamma-chain, anti-VEGF monoclonal antibody, Avastin | VEGF antagonist | | Nivolumab | BMS-936558, ONO-4538, MDX-1106, Anti-PD-1 human mab MDX-1106, Opdivo | Blocks PD-L1/2 inhibition of T cells | | Rucaparib | AG-014699, PF 01367338, CO-338, Rubraca | PARP inhibitor |
|
| NCT02571725 | II | Recurrent ovarian cancer with germline BRCA1/2 mutations (no prior anti-CTLA-4 mAb) | A Phase 1-2 Study of the Combination of Olaparib and Tremelimumab, in BRCA1 and BRCA2 Mutation Carriers With Recurrent Ovarian Cancer | View Drugs | Florida, New Mexico, Ohio, Virginia |
| Olaparib | AZD2281, Lynparza | PARP inhibitor | | Tremelimumab | anti-CTLA4 human monoclonal antibody CP-675,206, CP-675, CP-675,206, CP-675206, Ticilimumab | Blocks CTLA-4 inhibition of T cells |
|
| NCT02843165 | II | Advanced solid tumors with lesion treatable with radiation therapy | Randomized Phase II Study of Checkpoint Blockade Immunotherapy Combined With Stereotactic Body Radiation Therapy in Advanced Metastatic Disease | View Drugs | California |
| Atezolizumab | Tecentriq, Anti-PD-L1 Monoclonal Antibody MPDL3280A, MPDL3280A, RG7446 | Blocks PD-L1 inhibition of T cells | | Ipilimumab | Anti-Cytotoxic T-Lymphocyte-Associated Antigen-4 Monoclonal Antibody, MDX-010, Yervoy | Blocks CTLA-4 inhibition of T cells | | Nivolumab | BMS-936558, ONO-4538, MDX-1106, Anti-PD-1 human mab MDX-1106, Opdivo | Blocks PD-L1/2 inhibition of T cells | | Pembrolizumab | Keytruda, Lambrolizumab, SCH 900475, MK3475, MK-3475 | Blocks PD-L1/2 inhibition of T cells | | Radiation Therapy | Radiotherapy, Irradiation | |
|
| NCT03428802 | II | Advanced solid tumors with POLE, POLD, or BRCA1/2 mutations | A Basket Trial of Pembrolizumab in Patients With Advanced Solid Tumors and Genomic Instability | View Drugs | New Jersey |
| Pembrolizumab | Keytruda, Lambrolizumab, SCH 900475, MK3475, MK-3475 | Blocks PD-L1/2 inhibition of T cells |
|
| NCT03462342 | II | Recurrent ovarian cancer | Combination ATR and PARP Inhibitor (CAPRI) Trial With AZD 6738 and Olaparib in Recurrent Ovarian Cancer | View Drugs | Pennsylvania |
| Ceralasertib | AZD6738, ATR kinase inhibitor AZD6738 | ATR kinase inhibitor | | Olaparib | AZD2281, Lynparza | PARP inhibitor |
|
| NCT01876511 | II | Advanced solid tumors with positive MSI or tumors with negative MSI and high TMB | Phase 2 Study of MK-3475 in Patients With Microsatellite Unstable (MSI) Tumors | View Drugs | California, Maryland, New York, Ohio, Oregon, Pennsylvania |
| Pembrolizumab | Keytruda, Lambrolizumab, SCH 900475, MK3475, MK-3475 | Blocks PD-L1/2 inhibition of T cells |
|
| NCT03570619 | II | Advanced solid tumors with CDK12 alterations | IMPACT: Immunotherapy in Patients With Metastatic Cancers and CDK12 Mutations | View Drugs | Florida, Maryland, Michigan, Missouri, New York |
| Ipilimumab | Anti-Cytotoxic T-Lymphocyte-Associated Antigen-4 Monoclonal Antibody, MDX-010, Yervoy | Blocks CTLA-4 inhibition of T cells | | Nivolumab | BMS-936558, ONO-4538, MDX-1106, Anti-PD-1 human mab MDX-1106, Opdivo | Blocks PD-L1/2 inhibition of T cells |
|
| NCT03579316 | II | Recurrent ovarian cancer (PD on or after prior PARP inhibitor) | A Randomized 2-Arm, Non-Comparative Phase 2 Study of AZD1775 Alone or AZD1775 and Olaparib in Ovarian Cancer Patients Who Have Progressed During PARP Inhibition | View Drugs | Massachusetts, Texas |
| Adavosertib | WEE1 inhibitor AZD1775, MK1775, AZD1775 | WEE1 inhibitor | | Olaparib | AZD2281, Lynparza | PARP inhibitor |
|
| NCT03610490 | II | Recurrent or refractory high grade serous ovarian cancer or carcinosarcoma | Clinical Study to Assess Efficacy and Safety of MDA-TIL (Autologous Expanded Tumor Infiltrating Lymphocytes) Across Multiple Tumor Types | View Drugs | Texas |
| MDA-TIL | autologous tumor-infiltrating lymphocytes MDA-TIL | Anti-tumor immune response |
|
| NCT03651271 | II | Recurrent ovarian cancer with high MSI | An Exploratory Study of Nivolumab With or Without Ipilimumab According to the Percentage of Tumoral CD8 Cells in Participants With Advanced Metastatic Cancer | View Drugs | California, Massachusetts, New York, Texas |
| Ipilimumab | Anti-Cytotoxic T-Lymphocyte-Associated Antigen-4 Monoclonal Antibody, MDX-010, Yervoy | Blocks CTLA-4 inhibition of T cells | | Nivolumab | BMS-936558, ONO-4538, MDX-1106, Anti-PD-1 human mab MDX-1106, Opdivo | Blocks PD-L1/2 inhibition of T cells |
|
| NCT03693014 | II | Advanced solid tumors with limited progression on checkpoint inhibitor treatment | A Phase II Trial of Hypofractionated Radiotherapy in Patients With Limited Progression on Immune Checkpoint Blockade | View Drugs | New Jersey, New York |
| Atezolizumab | Tecentriq, Anti-PD-L1 Monoclonal Antibody MPDL3280A, MPDL3280A, RG7446 | Blocks PD-L1 inhibition of T cells | | Ipilimumab | Anti-Cytotoxic T-Lymphocyte-Associated Antigen-4 Monoclonal Antibody, MDX-010, Yervoy | Blocks CTLA-4 inhibition of T cells | | Nivolumab | BMS-936558, ONO-4538, MDX-1106, Anti-PD-1 human mab MDX-1106, Opdivo | Blocks PD-L1/2 inhibition of T cells | | Pembrolizumab | Keytruda, Lambrolizumab, SCH 900475, MK3475, MK-3475 | Blocks PD-L1/2 inhibition of T cells | | Radiation Therapy | Radiotherapy, Irradiation | |
|
| NCT03732950 | II | Recurrent ovarian cancer | A Phase II Study of Pembrolizumab Monotherapy in Recurrent Ovarian Cancer of the Immunoreactive Subtype Determined by NanoString Gene Expression Profiling | View Drugs | California, Minnesota |
| Pembrolizumab | Keytruda, Lambrolizumab, SCH 900475, MK3475, MK-3475 | Blocks PD-L1/2 inhibition of T cells |
|
| NCT03734692 | II | Platinum sensitive ovarian cancer with first or second recurrence in peritoneal cavity | Systemic Immune Checkpoint Blockade and Intraperitoneal Chemo-Immunotherapy in Recurrent Ovarian Cancer | View Drugs | Pennsylvania |
| Cisplatin | CACP, cis-DDP, cis-platinum, CDDP, Platinol, Abiplatin, Blastolem, Briplatin, Cisplatyl, Citoplatino, Citosin, Lederplatin, Metaplatin, Neoplatin, Placis, Platamine, Platiblastin, Platiblastin-S, Platinex, Platinol, Platiran, Platistin, Platosin | DNA damaging agent | | Pembrolizumab | Keytruda, Lambrolizumab, SCH 900475, MK3475, MK-3475 | Blocks PD-L1/2 inhibition of T cells | | Rintatolimod | Atvogen, Ampligen | TLR-3 agonist and immune cell stimulator |
|
| NCT03673124 | II | Recurrent low grade serous ovarian cancer | A Phase II Trial of Ribociclib (LEE011) Plus Letrozole in Women With Recurrent Low-Grade Serous Carcinoma of the Ovary, Fallopian Tube or Peritoneum | View Drugs | Florida, Georgia, Illinois, Indiana, New Mexico, Oklahoma, Pennsylvania, Rhode Island, Texas |
| Letrozole | Femara | Aromatase inhibitor | | Ribociclib | Kisqali, CDK4/6 Inhibitor LEE011, LEE011, Kisqali | CDK4/6 inhibitor |
|
| NCT03742895 | II | Advanced BRCA1/2-wild type solid tumors with DNA repair gene mutations (e.g., ATM, PALB2, RAD51D) or HRD+ | A Phase 2 Study of Olaparib Monotherapy in Participants With Previously Treated, Homologous Recombination Repair Mutation (HRRm) or Homologous Recombination Deficiency (HRD) Positive Advanced Cancer | View Drugs | California, Georgia, Kentucky, Maryland, Massachusetts, Michigan, Nebraska, New Jersey, New York, Oklahoma, Pennsylvania, South Dakota, Utah, Washington |
| Olaparib | AZD2281, Lynparza | PARP inhibitor |
|
| NCT03834220 | II | Advanced solid tumors with a FGFR1, FGFR2 or FGFR3 fusion | A Phase II Basket Study of the Oral Selective Pan-FGFR Inhibitor Debio 1347 in Subjects With Solid Tumors Harboring a Fusion of FGFR1, FGFR2 or FGFR3 | View Drugs | Arizona, California, Florida, Louisiana, Maryland, Massachusetts, New Jersey, New York, North Carolina, Ohio, Oklahoma, Texas, Washington, Wisconsin |
| Debiopharm 1347 | FGFR Inhibitor Debio 1347, FF284, CH5183284, Debio 1347 | FGFR1-3 inhibitor |
|
| NCT03836352 | II | Recurrent ovarian cancer (with tumor lesions < 5 cm) | A Phase 2, Open-label, Multicenter, Study of an Immunotherapeutic Treatment, DPX-Survivac in Combination With Low Dose Cyclophosphamide and Pembrolizumab, in Subjects With Selected Advanced and Recurrent Solid Tumours. | View Drugs | Florida, Louisiana, New York, Texas |
| Cyclophosphamide | Sendoxan, Procytox, Ledoxina, Genoxal, Fosfaseron, Enduxan, Endoxana, Endoxan, Cytophosphan, Cyclostine, Cyclostin, CYCLO-cell, Cycloblastine, Cycloblastin, Cicloxal, Carloxan, Neosar, Cytoxan, Clafen, Zytoxan, Syklofosfamid, Mitoxan, Cytophosphane, Cyclophosphanum, Cyclophosphan, Cyclophosphamidum, Cyclophosphamid monohydrate, Cyclophospham, CPM, CP monohydrate, Claphene, Ciclofosfamide, Ciclofosfamida | DNA damaging agent | | DPX-Survivac | survivin antigen vaccine DPX-Survivac | Immune response against cancer expressing survivin | | Pembrolizumab | Keytruda, Lambrolizumab, SCH 900475, MK3475, MK-3475 | Blocks PD-L1/2 inhibition of T cells |
|
| NCT03868423 | II | Advanced solid tumors with ALK or ROS1 activating genomic aberrations | Phase II Study of Brigatinib for Advanced Solid Cancers Harboring Genomic Alterations in ALK (Excluding Lung) and ROS1 Oncogenes | View Drugs | Ohio |
| Brigatinib | AP26113 | ALK and EGFR kinase inhibitor |
|
| NCT03697304 | II | Advanced solid tumors with prior PD-1/PD-L1 targeted treatment | An Open-label, Phase II, Platform Trial Evaluating Safety and Efficacy of Multiple BI 754091 Anti-PD-1 Based Combination Regimens in PD-(L)1 naïve and PD-(L)1 Pretreated Patient Populations With Advanced and/or Metastatic Solid Tumours Who Have Had at Least One Line of Systemic Therapy | View Drugs | California, Florida, Indiana, Kentucky, Oklahoma, Tennessee, Wisconsin |
| BI 754091 | anti-PD-1 monoclonal antibody BI 754091 | Blocks PD-L1/2 inhibition of T cells | | BI 754111 | | Blocks LAG-3 inhibition of T cells |
|
| NCT03878849 | II | Recurrent ovarian cancer | Phase II, Prospective Open Label, Single Arm Study to Investigate Anti-tumor Effect and Tolerability of 2X-121 in Patients With Advanced Ovarian Cancer Selected by the 2X-121 DRP® | View Drugs | Massachusetts |
|
| NCT02819843 | II | Advanced solid tumors - intratumoral injection | A Phase II Randomized Trial of Intralesional Talimogene Laherparepvec (TALIMOGENE LAHERPAREPVEC) With or Without Radiotherapy for Cutaneous Melanoma, Merkel Cell Carcinoma, or Other Solid Tumors | View Drugs | New Jersey, New York |
| Radiation Therapy | Radiotherapy, Irradiation | | | Talimogene Laherparepvec | GM-CSF-encoding oncolytic herpes simplex virus, T-VEC | Induces immune response and tumor cell lysis |
|
| NCT03909152 | II | Recurrent PR+ low grade serous or granulosa cell ovarian cancer | Basket Study of the Oral Progesterone Antagonist Onapristone ER (Apristor) in Women With Progesterone Receptor Positive (PR+) Recurrent Granulosa Cell Tumor, Low Grade Serous Ovarian Cancer or Endometrioid Endometrial Cancer | View Drugs | New Jersey, New York |
| Onapristone ER | extended-release onapristone | PR antagonist that blocks PR activation and the associated expression of PR-responsive genes |
|
| NCT03911557 | II | Advanced solid tumors with moderate/high TMB | Phase 2 Investigation of MEDI4736 (Durvalumab) and Tremelimumab Combination in Somatically Hypermutated Recurrent Solid Tumors | View Drugs | Kentucky |
| Durvalumab | Anti-B7H1 Monoclonal Antibody MEDI4736, MEDI4736, Imfinzi | Blocks PD-L1 inhibition of T cells | | Tremelimumab | anti-CTLA4 human monoclonal antibody CP-675,206, CP-675, CP-675,206, CP-675206, Ticilimumab | Blocks CTLA-4 inhibition of T cells |
|
| NCT03824704 | II | Recurrent carcinosarcoma, high grade serous or endometrioid ovarian cancer | A Phase 2, Open-label Study to Evaluate Rucaparib in Combination With Nivolumab in Patients With Selected Solid Tumors (ARIES) | View Drugs | California, Georgia, Louisiana, Oklahoma, Vermont |
| Nivolumab | BMS-936558, ONO-4538, MDX-1106, Anti-PD-1 human mab MDX-1106, Opdivo | Blocks PD-L1/2 inhibition of T cells | | Rucaparib | AG-014699, PF 01367338, CO-338, Rubraca | PARP inhibitor |
|
| NCT03907475 | II | Advanced solid tumors (with tumor amenable to skin biopsy) | DURVA+ : Evaluation of the Safety and Pharmacodynamics of Anti-PD-L1 Antibody MEDI4736 (Durvalumab) in Combination With Chemotherapy in Patients With Advanced Solid Tumors | View Drugs | Maryland |
| Capecitabine | CAPE, Xeloda | RNA processing and thymidylate synthase inhibitor | | Carboplatin | Paraplatin, Novoplatinum | DNA damaging agent | | Durvalumab | Anti-B7H1 Monoclonal Antibody MEDI4736, MEDI4736, Imfinzi | Blocks PD-L1 inhibition of T cells | | Gemcitabine | Gemzar | Ribonucleotide reductase and DNA synthesis inhibitor | | Liposomal doxorubicin | Doxil, Dox-SL, Evacet, LipoDox, liposomal doxorubicin, Pegylated Liposomal Doxorubicin Hydrochloride | Topoisomerase II inhibitor | | nab-Paclitaxel | Paclitaxel Albumin-Stabilized Nanoparticle Formula, Abraxane, ABI-007 | Microtubule stabilizer/mitotic inhibitor | | Paclitaxel | Anzatax, Asotax, Bristaxol, Praxel, Taxol, Taxol Konzentrat, TXL | Microtubule stabilizer/mitotic inhibitor |
|
| NCT02710253 | II | Advanced solid tumors (amenable to radiation therapy) - with progression on systemic immunotherapy | Phase II Trial of Salvage Radiation Therapy to Induce Systemic Disease Regression After Progression on Systemic Immunotherapy | View Drugs | Texas |
| Radiation Therapy | Radiotherapy, Irradiation | |
|
| NCT03449108 | II | Recurrent high grade serous ovarian cancer or carcinosarcoma | Clinical Study to Assess Efficacy and Safety of LN-145 (Autologous Centrally Manufactured Tumor Infiltrating Lymphocytes) Across Multiple Tumor Types | View Drugs | Texas |
| Aldesleukin | | IL-2 receptor agonist | | Cyclophosphamide | Sendoxan, Procytox, Ledoxina, Genoxal, Fosfaseron, Enduxan, Endoxana, Endoxan, Cytophosphan, Cyclostine, Cyclostin, CYCLO-cell, Cycloblastine, Cycloblastin, Cicloxal, Carloxan, Neosar, Cytoxan, Clafen, Zytoxan, Syklofosfamid, Mitoxan, Cytophosphane, Cyclophosphanum, Cyclophosphan, Cyclophosphamidum, Cyclophosphamid monohydrate, Cyclophospham, CPM, CP monohydrate, Claphene, Ciclofosfamide, Ciclofosfamida | DNA damaging agent | | Fludarabine | Fludara Oral, 2-F-ara-AMP, Beneflur | DNA synthesis inhibitor | | LN-145 | autologous TILs LN-145, autologous tumor infiltrating lymphocytes LN-145 | Anti-tumor immune response |
|
| NCT03994796 | II | Advanced solid tumors with brain metastases and NTRK, ROS1, CDK pathway or PI3K pathway alterations | Genomically-Guided Treatment Trial in Brain Metastases | View Drugs | Idaho, Iowa, Massachusetts, Michigan, Montana, New York, Ohio, Oregon, Pennsylvania, Vermont, Virginia, Wyoming |
| Abemaciclib | Bemaciclib, LY2853219, CDK4/6 Dual Inhibitor LY2835219, Verzenio | CDK4/6 inhibitor | | Entrectinib | TrkA/B/C/ROS1/ALK tyrosine kinase inhibitor RXDX-101, RXDX-101 | ALK, TRK, ROS1 kinase inhibitor | | GDC-0084 | RG7666, PI3K inhibitor GDC-0084 | PI3K/mTOR inhibitor |
|
| NCT03993379 | II | Advanced solid tumors | A Phase 2, Open-Label, Multi-cohort Study of PD-L1 Probody Therapeutic CX-072 in Combination With Other Anticancer Therapy in Adults With Solid Tumors | View Drugs | Idaho, Illinois, Oregon, Virginia |
| CX-072 | protease-activated anti-PD-L1 antibody prodrug CX-072 | Blocks PD-L1 inhibition of T cells |
|
| NCT03872427 | II | Advanced solid tumors with NF1, KEAP1/NRF2 or LKB1 mutations | A Phase II Basket Trial of Glutaminase Inhibitor (BeGIN) CB-839 HCl in Patients With NF1 Aberrations, NF1 Mutant Malignant Peripheral Nerve Sheath Tumors (MPNST), KEAP1/NRF2 and LKB1 Aberrant Tumors | View Drugs | Contact NCI |
| Telaglenastat | glutaminase inhibitor CB-839, CD-839 | Glutaminase inhibitor |
|
| NCT04082572 | II | Advanced solid tumors with loss of MLH1, PMS2, MSH2 or MSH6 or with high MSI | Neoadjuvant Pembrolizumab for Patients With Mismatch Repair Deficient Locally Advanced Solid Cancers | View Drugs | Texas |
| Pembrolizumab | Keytruda, Lambrolizumab, SCH 900475, MK3475, MK-3475 | Blocks PD-L1/2 inhibition of T cells |
|
| NCT04083976 | II | Advanced solid tumors with a FGFR mutation or gene fusion | A Phase 2 Study of Erdafitinib in Subjects With Advanced Solid Tumors and FGFR Gene Alterations | View Drugs | Maine, New Jersey, New York, Pennsylvania, Texas |
| Erdafitinib | pan-FGFR tyrosine kinase inhibitor JNJ-42756493 | pan-FGFR kinase inhibitor |
|
| NCT04098068 | II | Advanced solid tumors with high TMB and low MSI | Phase 2 Study of MK-3475 (an Antibody That Blocks Negative Signals to T Cells) in Patients With Microsatellite Unstable (MSI) Tumors | View Drugs | Maryland, Massachusetts, New York, Ohio, Oregon, Pennsylvania |
| Pembrolizumab | Keytruda, Lambrolizumab, SCH 900475, MK3475, MK-3475 | Blocks PD-L1/2 inhibition of T cells |
|
| NCT04034927 | II | Platinum sensitive high grade serous or endometrioid ovarian cancer or germline BRCA1/2-mutated ovarian cancer | A Phase II Randomized Trial of Olaparib Versus Olaparib Plus Tremelimumab in Platinum-Sensitive Recurrent Ovarian Cancer | View Drugs | Contact NCI |
| Olaparib | AZD2281, Lynparza | PARP inhibitor | | Tremelimumab | anti-CTLA4 human monoclonal antibody CP-675,206, CP-675, CP-675,206, CP-675206, Ticilimumab | Blocks CTLA-4 inhibition of T cells |
|
| NCT03861403 | Ib/IIa | Advanced solid tumors (inc ovarian expansion) | A Dose Escalation and Expansion Study of TRX518 in Combination With Cyclophosphamide Plus Avelumab in Advanced Solid Tumors | View Drugs | Indiana, New York, Ohio, Virginia |
| Avelumab | Anti programmed death ligand 1 monoclonal antibody, Anti-PD-L1, MSB0010718C, Bavencio | Blocks PD-L1 inhibition of T cells | | Cyclophosphamide | Sendoxan, Procytox, Ledoxina, Genoxal, Fosfaseron, Enduxan, Endoxana, Endoxan, Cytophosphan, Cyclostine, Cyclostin, CYCLO-cell, Cycloblastine, Cycloblastin, Cicloxal, Carloxan, Neosar, Cytoxan, Clafen, Zytoxan, Syklofosfamid, Mitoxan, Cytophosphane, Cyclophosphanum, Cyclophosphan, Cyclophosphamidum, Cyclophosphamid monohydrate, Cyclophospham, CPM, CP monohydrate, Claphene, Ciclofosfamide, Ciclofosfamida | DNA damaging agent | | TRX518 | anti-huGITR monoclonal antibody TRX518, anti-huGITR mAb TRX518, anti-huGITR MoAb TRX518 | GITR (glucocorticoid-induced TNFR) agonist |
|
| NCT04042116 | Ib/II | Advanced solid tumors (inc expansion) | A Phase 1b/2, Open-Label Study to Evaluate the Safety and Efficacy of Lucitanib in Combination With Nivolumab in Patients With an Advanced, Metastatic Solid Tumor | View Drugs | Florida, Tennessee |
| Lucitanib | VEGFR/FGFR dual kinase inhibitor E-3810 | VEGFR and FGFR kinase inhibitor | | Nivolumab | BMS-936558, ONO-4538, MDX-1106, Anti-PD-1 human mab MDX-1106, Opdivo | Blocks PD-L1/2 inhibition of T cells |
|
| NCT03717415 | Ib/II | Advanced solid tumors | An Open Label, Multicenter, Phase 1b/2 Study of Rebastinib (DCC-2036) in Combination With Carboplatin to Assess Safety, Tolerability, and Pharmacokinetics in Patients With Advanced or Metastatic Solid Tumors | View Drugs | California, Ohio, Texas |
| Carboplatin | Paraplatin, Novoplatinum | DNA damaging agent | | Rebastinib | multitargeted tyrosine kinase inhibitor DCC-2036 | Multi-targeted kinase inhibitor |
|
| NCT03330405 | Ib/II | Platinum sensitive recurrent ovarian cancer | A Phase 1b/2 Study To Evaluate Safety And Anti Tumor Activity Of Avelumab In Combination With The Poly(Adenosine Diphosphate [Adp]-Ribose) Polymerase (Parp) Inhibitor Talazoparib In Patients With Locally Advanced Or Metastatic Solid Tumors | View Drugs | Arkansas, California, District of Columbia, Massachusetts, Michigan, Minnesota, New York, Ohio, Pennsylvania, Texas |
| Avelumab | Anti programmed death ligand 1 monoclonal antibody, Anti-PD-L1, MSB0010718C, Bavencio | Blocks PD-L1 inhibition of T cells | | Talazoparib | Talazoparib Tosylate, BMN-673, MDV3800 | PARP inhibitor |
|
| NCT02759588 | Ib/II | Platinum resistant, refractory or partially sensitive ovarian cancer (with peritoneal disease) | Phase 1b & 2 Study With GL-ONC1 Oncolytic Immunotherapy in Patients With Recurrent or Refractory Ovarian Cancer (VIRO-15) | View Drugs | California, Florida |
| Bevacizumab | immunoglobulin G1 (human-mouse monoclonal rhuMab-VEGF gamma-chain, anti-VEGF monoclonal antibody, Avastin | VEGF antagonist | | Carboplatin | Paraplatin, Novoplatinum | DNA damaging agent | | Docetaxel | Taxotere | Microtubule stabilizer/mitotic inhibitor | | Gemcitabine | Gemzar | Ribonucleotide reductase and DNA synthesis inhibitor | | GL-ONC1 | light-emitting oncolytic vaccinia virus GL-ONC1, GLV-1h68 | Membrane disrupter | | Liposomal doxorubicin | Doxil, Dox-SL, Evacet, LipoDox, liposomal doxorubicin, Pegylated Liposomal Doxorubicin Hydrochloride | Topoisomerase II inhibitor | | Paclitaxel | Anzatax, Asotax, Bristaxol, Praxel, Taxol, Taxol Konzentrat, TXL | Microtubule stabilizer/mitotic inhibitor |
|
| NCT02785250 | Ib/II | Recurrent ovarian cancer | A Phase 1b/2 Study of an Immunotherapeutic Vaccine, DPX-Survivac With Low Dose Cyclophosphamide and Epacadostat (INCB024360) in Patients With Recurrent Ovarian Cancer | View Drugs | California, Georgia, New York, Oregon, Pennsylvania, Texas |
| Cyclophosphamide | Sendoxan, Procytox, Ledoxina, Genoxal, Fosfaseron, Enduxan, Endoxana, Endoxan, Cytophosphan, Cyclostine, Cyclostin, CYCLO-cell, Cycloblastine, Cycloblastin, Cicloxal, Carloxan, Neosar, Cytoxan, Clafen, Zytoxan, Syklofosfamid, Mitoxan, Cytophosphane, Cyclophosphanum, Cyclophosphan, Cyclophosphamidum, Cyclophosphamid monohydrate, Cyclophospham, CPM, CP monohydrate, Claphene, Ciclofosfamide, Ciclofosfamida | DNA damaging agent | | DPX-Survivac | survivin antigen vaccine DPX-Survivac | Immune response against cancer expressing survivin |
|
| NCT02994953 | Ib | Advanced solid tumors | A Phase Ib Open‑Label, Dose‑Finding Trial to Evaluate the Safety, Tolerability, and Pharmacokinetics of Avelumab in Combination With M9241(NHS-IL12) in Subjects With Locally Advanced, Unresectable, or Metastatic Solid Tumors | View Drugs | California, Connecticut, Florida, Louisiana, Minnesota, Missouri, Ohio, Oklahoma, Oregon, South Carolina, Texas, Vermont, Washington |
| Avelumab | Anti programmed death ligand 1 monoclonal antibody, Anti-PD-L1, MSB0010718C, Bavencio | Blocks PD-L1 inhibition of T cells | | NHS-IL12 | M9241, immunocytokine NHS-IL12 | IL-12 receptor agonist |
|
| NCT02761694 | Ib | Advanced solid tumors with AKT1/2/3, PI3K, or PTEN mutations (in expansion) | A Phase 1b Study of ARQ 751 as a Single Agent or in Combination With Other Anti-Cancer Agents in Adult Subjects With Advanced Solid Tumors With PIK3CA / AKT / PTEN Mutations | View Drugs | Oklahoma, Tennessee, Texas |
| ARQ 751 | pan-AKT inhibitor ARQ 751 | Akt inhibitor | | Fulvestrant | Faslodex, ICI 182,780, ZD9238 | ER antagonist (SERD) | | Paclitaxel | Anzatax, Asotax, Bristaxol, Praxel, Taxol, Taxol Konzentrat, TXL | Microtubule stabilizer/mitotic inhibitor |
|
| NCT03150810 | Ib | Advanced solid tumors (inc ovarian expansion) | A Phase 1b Study to Assess the Safety, Tolerability and Clinical Activity of BGB-290 in Combination With Temozolomide (TMZ) in Subjects With Locally Advanced or Metastatic Solid Tumors | View Drugs | Michigan, Missouri, New York, Tennessee, Texas |
| Pamiparib | PARP inhibitor BGB-290 | PARP inhibitor | | Temozolomide | Temodal, Temodar, Methazolastone | DNA damaging agent |
|
| NCT03113188 | Ib | Advanced solid tumors | Phase 1b Clinical Study of CBP501, Cisplatin and Nivolumab Administered Every 3 Weeks in Patients With Advanced Refractory Tumors | View Drugs | Arizona, Louisiana, Massachusetts |
| CBP501 | G2 checkpoint inhibitor CBP501 | G2 checkpoint inhibitor | | Cisplatin | CACP, cis-DDP, cis-platinum, CDDP, Platinol, Abiplatin, Blastolem, Briplatin, Cisplatyl, Citoplatino, Citosin, Lederplatin, Metaplatin, Neoplatin, Placis, Platamine, Platiblastin, Platiblastin-S, Platinex, Platinol, Platiran, Platistin, Platosin | DNA damaging agent | | Nivolumab | BMS-936558, ONO-4538, MDX-1106, Anti-PD-1 human mab MDX-1106, Opdivo | Blocks PD-L1/2 inhibition of T cells |
|
| NCT03206177 | Ib | Newly diagnosed, persistent, or recurrent ovarian carcinosarcoma | Feasibility IB Trial of Paclitaxel/Carboplatin + Galunisertib (a Small Molecule Inhibitor of the Kinase Domain of Type 1 TGF-B Receptor) in Patients With Newly Diagnosed, Persistent or Recurrent Carcinosarcoma of the Uterus or Ovary | View Drugs | Oklahoma |
| Carboplatin | Paraplatin, Novoplatinum | DNA damaging agent | | Galunisertib | LY2157299 | TGFBR1 antagonist | | Paclitaxel | Anzatax, Asotax, Bristaxol, Praxel, Taxol, Taxol Konzentrat, TXL | Microtubule stabilizer/mitotic inhibitor |
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| NCT03307785 | Ib | Advanced solid tumors | Phase 1b Dose-Finding Study of Niraparib, TSR-022, Bevacizumab, and Platinum-Based Doublet Chemotherapy in Combination With TSR-042 in Patients With Advanced or Metastatic Cancer | View Drugs | Arizona, California, Florida, Michigan, New Mexico, Ohio, Oklahoma, South Carolina, Tennessee, Texas |
| Bevacizumab | immunoglobulin G1 (human-mouse monoclonal rhuMab-VEGF gamma-chain, anti-VEGF monoclonal antibody, Avastin | VEGF antagonist | | Carboplatin | Paraplatin, Novoplatinum | DNA damaging agent | | Dostarlimab | ANB011, anti-PD-1 monoclonal antibody TSR-042, TSR-042 | Blocks PD-L1/2 inhibition of T cells | | Niraparib | MK4827, Zejula | PARP inhibitor | | Paclitaxel | Anzatax, Asotax, Bristaxol, Praxel, Taxol, Taxol Konzentrat, TXL | Microtubule stabilizer/mitotic inhibitor | | TSR-022 | | Blocks TIM-3 inhibition of T cells |
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| NCT03318445 | Ib | Advanced solid tumors with BRCA1, BRCA2, ATM, BARD1, BRIP1, CDK12, CHEK2, FANCA, NBN, PALB2, RAD51, RAD51B, RAD51C, RAD51D, or RAD54L mutations (inc expansion) | Combination Therapy of Rucaparib and Irinotecan in Cancers With Mutations in DNA Repair | View Drugs | California |
| Irinotecan | Campothecin-11, Campto, Camptosar | Topoisomerase I inhibitor | | Rucaparib | AG-014699, PF 01367338, CO-338, Rubraca | PARP inhibitor |
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| NCT03695380 | Ib | Platinum sensitive ovarian cancer with ≤ 2 prior platinum therapies (inc expansion) | A Phase Ib Study of Cobimetinib Administered in Combination With Niraparib, With or Without Atezolizumab, To Patients With Advanced Platinum-sensitive Ovarian Cancer | View Drugs | Arizona, California, Florida, Georgia, Maryland, Missouri, New York, Oklahoma, Tennessee, Wisconsin |
| Atezolizumab | Tecentriq, Anti-PD-L1 Monoclonal Antibody MPDL3280A, MPDL3280A, RG7446 | Blocks PD-L1 inhibition of T cells | | Cobimetinib | XL518, GDC-0973, Cotellic | MEK1 inhibitor | | Niraparib | MK4827, Zejula | PARP inhibitor |
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| NCT03650348 | Ib | Advanced HER2+ solid tumors (inc expansion) | A Phase 1b, Open-Label, Dose Escalation Study of PRS-343 in Combination With Atezolizumab in Patients With HER2-Positive Advanced or Metastatic Solid Tumors | View Drugs | California, Louisiana, New York, Ohio, Texas |
| Atezolizumab | Tecentriq, Anti-PD-L1 Monoclonal Antibody MPDL3280A, MPDL3280A, RG7446 | Blocks PD-L1 inhibition of T cells | | PRS-343 | anti-HER2 monoclonal antibody/anti-CD137 anticalin bispecific fusion protein PRS-343 | Immune response against cancer expressing HER2 |
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| NCT03589651 | Ib | Advanced solid tumors (inc expansion) | A Phase 1b Study of INCMGA00012 in Combination With Other Therapies in Patients With Advanced Solid Tumors | View Drugs | California, Connecticut, Florida, Illinois, New Jersey, New York, Pennsylvania, Texas |
| Epacadostat | 3-dioxygenase Inhibitor INCB024360, Indoleamine-2,3-dioxygenase Inhibitor INCB024360, INCB024360, IDO1 Inhibitor INCB024360 | Inhibits IDO1 to stimulate immune response | | INCB050465 | PI3K-delta inhibitor INCB050465 | PI3K delta inhibitor | | MGA012 | anti-PD-1 monoclonal antibody MGA012, INCMGA00012 | Blocks PD-L1 inhibition of T cells |
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| NCT03872947 | Ib | Platinum sensitive or partially sensitive ovarian cancer | A Phase 1b, Multicenter Study to Determine the Dose, Safety, Efficacy and Pharmacokinetics of TRK-950 When Used in Combinations With Selected Anti-Cancer Treatment Regimens in Patients With Selected Advanced Solid Tumors | View Drugs | Arizona, California, Louisiana, New Jersey, Wisconsin |
| Carboplatin | Paraplatin, Novoplatinum | DNA damaging agent | | Gemcitabine | Gemzar | Ribonucleotide reductase and DNA synthesis inhibitor | | Pembrolizumab | Keytruda, Lambrolizumab, SCH 900475, MK3475, MK-3475 | Blocks PD-L1/2 inhibition of T cells | | TRK-950 | monoclonal antibody TRK-950 | Undisclosed mechanism |
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| NCT03842228 | Ib | Advanced solid tumors (inc expansion) | A Phase 1b Biomarker-Driven Combination Trial of Copanlisib, Olaparib, and MEDI4736 (Durvalumab) in Patients With Advanced Solid Tumors | View Drugs | Contact NCI |
| Copanlisib | BAY 80-6946, MEK inhibitor BAY 80-6946, PI3K inhibitor BAY 80-6946 | pan-PI3K inhibitor | | Durvalumab | Anti-B7H1 Monoclonal Antibody MEDI4736, MEDI4736, Imfinzi | Blocks PD-L1 inhibition of T cells | | Olaparib | AZD2281, Lynparza | PARP inhibitor |
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| NCT03514121 | Ia/Ib | Advanced solid tumors (in ovarian expansion) | A Phase 1a/1b Study of FPA150, an Anti-B7-H4 Antibody, in Patients With Advanced Solid Tumors | View Drugs | Arizona, California, Connecticut, Illinois, Michigan, Oklahoma, Tennessee, Texas, Utah, Washington |
| FPA150 | anti-B7-H4 monoclonal antibody FPA150 | Blocks B7-H4 inhibition of T cells | | Pembrolizumab | Keytruda, Lambrolizumab, SCH 900475, MK3475, MK-3475 | Blocks PD-L1/2 inhibition of T cells |
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| NCT03209401 | Ia/Ib | Advanced solid tumors with mutations in ARID1A, ATM, ATRX, MRE11A, NBN, PTEN, RAD50/51/51B, BARD1, BLM, BRCA1/2, BRIP1, FANCA/C/D2/E/F/G/L, PALB2, WRN, CHEK2, CHEK1, BAP1, FAM175A, SLX4, MLL2 or XRCC (inc expansion) | Niraparib Plus Carboplatin in Patients With Homologous Recombination Deficient Advanced Solid Tumor Malignancies | View Drugs | District of Columbia |
| Carboplatin | Paraplatin, Novoplatinum | DNA damaging agent | | Niraparib | MK4827, Zejula | PARP inhibitor |
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| NCT02913313 | I/IIa | Advanced solid tumors | Phase 1/2a First-In-Human Study of BMS-986207 Monoclonal Antibody Alone and in Combination With Nivolumab in Advanced Solid Tumors | View Drugs | Pennsylvania, Utah |
| BMS-986207 | anti-TIGIT monoclonal antibody BMS-986207 | Blocks T cell binding to CD112 and CD155 to enable activation of CD226 signaling in NK and CD8 T cells | | Nivolumab | BMS-936558, ONO-4538, MDX-1106, Anti-PD-1 human mab MDX-1106, Opdivo | Blocks PD-L1/2 inhibition of T cells |
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| NCT02754141 | I/IIa | Advanced solid tumors | A Phase 1/2a Study of BMS-986179 Administered Alone and in Combination With Nivolumab (BMS-936558) in Subjects With Advanced Solid Tumors | View Drugs | Connecticut, Illinois, Maryland, Massachusetts, New York, Oklahoma, Tennessee, Texas |
| BMS-986179 | anti-CD73 monoclonal antibody BMS-986179 | Blocks Ecto-5-nucleotidase (CD73) inhibition of T cells | | Nivolumab | BMS-936558, ONO-4538, MDX-1106, Anti-PD-1 human mab MDX-1106, Opdivo | Blocks PD-L1/2 inhibition of T cells |
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| NCT03110107 | I/IIa | Advanced solid tumors (in expansion) | Phase 1/2a First-In-Human Study of BMS-986218 Monoclonal Antibody Alone and in Combination With Nivolumab in Advanced Solid Tumors | View Drugs | Colorado, Massachusetts, Nevada, New Jersey, New York, Pennsylvania |
| BMS-986218 | | Blocks CTLA-4 inhibition of T cells | | Ipilimumab | Anti-Cytotoxic T-Lymphocyte-Associated Antigen-4 Monoclonal Antibody, MDX-010, Yervoy | Blocks CTLA-4 inhibition of T cells | | Nivolumab | BMS-936558, ONO-4538, MDX-1106, Anti-PD-1 human mab MDX-1106, Opdivo | Blocks PD-L1/2 inhibition of T cells |
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| NCT02650986 | I/IIa | Advanced solid tumors (inc expansion) | A Phase I/IIa Study of TGFß Blockade in TCR-Engineered T-Cell Cancer Immunotherapy in Patients With Advanced Malignancies | View Drugs | New York |
| Cyclophosphamide | Sendoxan, Procytox, Ledoxina, Genoxal, Fosfaseron, Enduxan, Endoxana, Endoxan, Cytophosphan, Cyclostine, Cyclostin, CYCLO-cell, Cycloblastine, Cycloblastin, Cicloxal, Carloxan, Neosar, Cytoxan, Clafen, Zytoxan, Syklofosfamid, Mitoxan, Cytophosphane, Cyclophosphanum, Cyclophosphan, Cyclophosphamidum, Cyclophosphamid monohydrate, Cyclophospham, CPM, CP monohydrate, Claphene, Ciclofosfamide, Ciclofosfamida | DNA damaging agent | | NY-ESO-1 reactive TCR retroviral vector transduced autologous PBL | anti-NY-ESO-1 TCR gene-engineered lymphocytes | Immune response against cancer expressing NY-ESO-1 | | TGFbeta DNRII-transduced Autologous Tumor Infiltrating Lymphocytes | TGFbeta Dominant Negative Receptor II transduced TILS | TGFbeta ligand trap |
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| NCT02111850 | I/II | Advanced MAGE-3+ solid tumors | Phase I/II Study of the Treatment of Metastatic Cancer That Expresses MAGE-A3 Using Lymphodepleting Conditioning Followed by Infusion of HLA-DP0401/0402 Restricted Anti-MAGE-A3 TCR-Gene Engineered Lymphocytes and Aldesleukin | View Drugs | Maryland |
| Aldesleukin | | IL-2 receptor agonist | | Anti-MAGE-A3-DP4 TCR PBL | HLA-DP0401/0402-restricted, MAGE-A3-reactive T cell receptor-transduced autologous T cells | Immune response against cancer expressing MAGE-3 | | Cyclophosphamide | Sendoxan, Procytox, Ledoxina, Genoxal, Fosfaseron, Enduxan, Endoxana, Endoxan, Cytophosphan, Cyclostine, Cyclostin, CYCLO-cell, Cycloblastine, Cycloblastin, Cicloxal, Carloxan, Neosar, Cytoxan, Clafen, Zytoxan, Syklofosfamid, Mitoxan, Cytophosphane, Cyclophosphanum, Cyclophosphan, Cyclophosphamidum, Cyclophosphamid monohydrate, Cyclophospham, CPM, CP monohydrate, Claphene, Ciclofosfamide, Ciclofosfamida | DNA damaging agent | | Fludarabine | Fludara Oral, 2-F-ara-AMP, Beneflur | DNA synthesis inhibitor |
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| NCT02953457 | I/II | Recurrent, persistent or refractory high grade serous ovarian cancer with BRCA1/2 or HRD or MMR gene alterations or high LOH/HRD scores | A Phase I/II Evaluation of Olaparib in Combination With Durvalumab (Medi4736) and Tremelimumab in the Treatment of Recurrent Platinum Sensitive or Resistant or Refractory Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer in Patients Who Carry a BRCA1 or BRCA2 Mutation | View Drugs | New York |
| Durvalumab | Anti-B7H1 Monoclonal Antibody MEDI4736, MEDI4736, Imfinzi | Blocks PD-L1 inhibition of T cells | | Olaparib | AZD2281, Lynparza | PARP inhibitor | | Tremelimumab | anti-CTLA4 human monoclonal antibody CP-675,206, CP-675, CP-675,206, CP-675206, Ticilimumab | Blocks CTLA-4 inhibition of T cells |
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| NCT02432378 | I/II | Platinum sensitive ovarian cancer with first recurrence in peritoneal cavity - intranodal injection (inc expansion) | A Phase 1-2 Neoadjuvant Dose Finding, Safety, and Immunologic Efficacy Trial of Intensive Locoregional Chemoimmunotherapy for Recurrent Ovarian Cancer and Tumor-Specific Intranodal Autologous Alpha-DC1 Vaccines | View Drugs | Pennsylvania |
| Alpha-DC1 vaccine | | Anti-tumor immune response | | Celecoxib | Celebrex | | | Cisplatin | CACP, cis-DDP, cis-platinum, CDDP, Platinol, Abiplatin, Blastolem, Briplatin, Cisplatyl, Citoplatino, Citosin, Lederplatin, Metaplatin, Neoplatin, Placis, Platamine, Platiblastin, Platiblastin-S, Platinex, Platinol, Platiran, Platistin, Platosin | DNA damaging agent |
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| NCT02671435 | I/II | Advanced solid tumors | A Phase 1/2 Study of Durvalumab and Monalizumab in Adult Subjects With Select Advanced Solid Tumors | View Drugs | Alabama, Arizona, California, Colorado, Florida, Illinois, Maryland, Massachusetts, Michigan, New Jersey, New York, Pennsylvania, Rhode Island, Tennessee, Texas, Utah, Washington |
| Durvalumab | Anti-B7H1 Monoclonal Antibody MEDI4736, MEDI4736, Imfinzi | Blocks PD-L1 inhibition of T cells | | Monalizumab | IPH2201, anti-NKG2A monoclonal antibody IPH2201 | Blocks HLA-E inhibition of NKG2A+ NK and cytotoxic T-lymphocytes |
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| NCT02484404 | I/II | Recurrent ovarian cancer | Phase I/II Study of the Anti-Programmed Death Ligand-1 Antibody MEDI4736 in Combination With Olaparib and/or Cediranib for Advanced Solid Tumors and Advanced or Recurrent Ovarian, Triple Negative Breast, Lung, Prostate and Colorectal Cancers | View Drugs | Maryland |
| Cediranib | AZD2171, Cediranib maleate, Recentin | VEGFR1-3 kinase inhibitor | | Durvalumab | Anti-B7H1 Monoclonal Antibody MEDI4736, MEDI4736, Imfinzi | Blocks PD-L1 inhibition of T cells | | Olaparib | AZD2281, Lynparza | PARP inhibitor |
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| NCT02487095 | I/II | Extrapulmonary small cell ovarian cancer | A Phase I/II Trial of Topotecan With VX-970 (M6620), an ATR Kinase Inhibitor in Small Cell Cancers | View Drugs | Maryland |
| Berzosertib | M6620, VE-822, ATR kinase inhibitor VX-970, ATR kinase inhibitor VX-970 | ATR kinase inhibitor | | Topotecan | Hycamptamine, Hycamtin, TOPO | Topoisomerase I inhibitor |
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| NCT02734004 | I/II | Platinum sensitive recurrent ovarian cancer | A Phase I/II Study of MEDI4736 (Anti-PD-L1 Antibody) in Combination With Olaparib (PARP Inhibitor) in Patients With Advanced Solid Tumors | View Drugs | Georgia, Maryland, Massachusetts, Michigan, Missouri, Ohio, Pennsylvania, Texas |
| Bevacizumab | immunoglobulin G1 (human-mouse monoclonal rhuMab-VEGF gamma-chain, anti-VEGF monoclonal antibody, Avastin | VEGF antagonist | | Durvalumab | Anti-B7H1 Monoclonal Antibody MEDI4736, MEDI4736, Imfinzi | Blocks PD-L1 inhibition of T cells | | Olaparib | AZD2281, Lynparza | PARP inhibitor |
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| NCT03251924 | I/II | Advanced solid tumors | A Phase 1/2 Dose Escalation and Combination Cohort Study to Evaluate the Safety and Tolerability, Pharmacokinetics, and Efficacy of BMS-986226 Alone or in Combination With Nivolumab or Ipilimumab in Patients With Advanced Solid Tumors | View Drugs | District of Columbia, Massachusetts, Missouri, New Jersey, Pennsylvania, Tennessee |
| BMS-986226 | anti-ICOS BMS-986226, anti-inducible T-cell co-stimulator BMS-986226 | Stimulates ICOS to increase T cell activity and immune response | | Ipilimumab | Anti-Cytotoxic T-Lymphocyte-Associated Antigen-4 Monoclonal Antibody, MDX-010, Yervoy | Blocks CTLA-4 inhibition of T cells | | Nivolumab | BMS-936558, ONO-4538, MDX-1106, Anti-PD-1 human mab MDX-1106, Opdivo | Blocks PD-L1/2 inhibition of T cells |
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| NCT03314935 | I/II | Advanced solid tumors | A Phase 1/2 Study to Evaluate the Safety, Tolerability, and Efficacy of INCB001158 in Combination With Chemotherapy, in Subjects With Advanced or Metastatic Solid Tumors | View Drugs | Alabama, California, Georgia, Texas |
| Cisplatin | CACP, cis-DDP, cis-platinum, CDDP, Platinol, Abiplatin, Blastolem, Briplatin, Cisplatyl, Citoplatino, Citosin, Lederplatin, Metaplatin, Neoplatin, Placis, Platamine, Platiblastin, Platiblastin-S, Platinex, Platinol, Platiran, Platistin, Platosin | DNA damaging agent | | Gemcitabine | Gemzar | Ribonucleotide reductase and DNA synthesis inhibitor | | INCB001158 | CB-1158, Arginase inhibitor | Arginase inhibitor | | Paclitaxel | Anzatax, Asotax, Bristaxol, Praxel, Taxol, Taxol Konzentrat, TXL | Microtubule stabilizer/mitotic inhibitor |
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| NCT03446040 | I/II | Advanced solid tumors | A Phase 1/2 First-in-Human Study of BMS-986258 Alone and in Combination With Nivolumab in Advanced Malignant Tumors | View Drugs | California, Colorado, Connecticut, Michigan, New Hampshire, Pennsylvania, Tennessee |
| BMS-986258 | anti-TIM3 antibody BMS-986258 | Blocks TIM-3 inhibition of T cells | | Nivolumab | BMS-936558, ONO-4538, MDX-1106, Anti-PD-1 human mab MDX-1106, Opdivo | Blocks PD-L1/2 inhibition of T cells |
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| NCT03369223 | I/II | Advanced solid tumors | A Phase 1/2 First-in-Human Study of BMS-986249 Alone and in Combination With Nivolumab in Advanced Solid Tumors | View Drugs | Colorado, Florida, Maryland, New Jersey, New York, Ohio, Oregon, Pennsylvania, South Carolina, Texas, Virginia, Washington |
| BMS-986249 | Probody of ipilumumab | Blocks CTLA-4 inhibition of T cells | | Nivolumab | BMS-936558, ONO-4538, MDX-1106, Anti-PD-1 human mab MDX-1106, Opdivo | Blocks PD-L1/2 inhibition of T cells |
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| NCT03386526 | I/II | Advanced solid tumors | A Phase I Study of the Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Properties of APG-1387 as A Single Agent or in Combination With Systemic Anti-Cancer Agents in Patients With Advanced Solid Tumors or Hematologic Malignancies | View Drugs | Texas |
| APG-138 | SM-138 | SMAC mimetic and IAP antagonist | | Carboplatin | Paraplatin, Novoplatinum | DNA damaging agent | | Paclitaxel | Anzatax, Asotax, Bristaxol, Praxel, Taxol, Taxol Konzentrat, TXL | Microtubule stabilizer/mitotic inhibitor | | Pembrolizumab | Keytruda, Lambrolizumab, SCH 900475, MK3475, MK-3475 | Blocks PD-L1/2 inhibition of T cells |
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| NCT03400332 | I/II | Advanced solid tumors | A Phase 1/2a Study of BMS-986253 in Combination With Nivolumab in Advanced Cancers | View Drugs | Colorado, Florida, Maryland, Nevada, New Jersey, New York, Oklahoma, Oregon, Pennsylvania, South Carolina, Texas, Virginia |
| BMS-986253 | | IL-8 antagonist | | Nivolumab | BMS-936558, ONO-4538, MDX-1106, Anti-PD-1 human mab MDX-1106, Opdivo | Blocks PD-L1/2 inhibition of T cells |
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| NCT03407976 | I/II | Advanced solid tumors with high MSI or dMMR | A Phase I/II Open Label Study of the Safety and Efficacy of Apatinib Administered to Patients With Advanced Malignancies to Improve Sensitivity to Pembrolizumab in the Second- or Later-line Setting (APPEASE) | View Drugs | Utah |
| Apatinib | YN968D1, Aitan, ATAN, Rivoceranib | c-Met/VEGFR2 kinase inhibitor | | Pembrolizumab | Keytruda, Lambrolizumab, SCH 900475, MK3475, MK-3475 | Blocks PD-L1/2 inhibition of T cells |
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| NCT03721679 | I/II | Advanced solid cancers | Poly-ICLC (Hiltonol®) Plus Anti-PD1 or Anti-PD-L1 in Unresectable Solid Cancers An Adaptive Phase I/II Clinical Pilot Study | View Drugs | Maryland, New York |
| Atezolizumab | Tecentriq, Anti-PD-L1 Monoclonal Antibody MPDL3280A, MPDL3280A, RG7446 | Blocks PD-L1 inhibition of T cells | | Durvalumab | Anti-B7H1 Monoclonal Antibody MEDI4736, MEDI4736, Imfinzi | Blocks PD-L1 inhibition of T cells | | Nivolumab | BMS-936558, ONO-4538, MDX-1106, Anti-PD-1 human mab MDX-1106, Opdivo | Blocks PD-L1/2 inhibition of T cells | | Pembrolizumab | Keytruda, Lambrolizumab, SCH 900475, MK3475, MK-3475 | Blocks PD-L1/2 inhibition of T cells | | poly ICLC | poly-ICLC, Hiltonol, Polyinosinic-Polycytidylic Acid Stabilized with Polylysine and Carboxymethylcellulose, poly I:poly C with poly-1-lysine stabilizer | Activates dendritic cells and induces interferon production |
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| NCT03775850 | I/II | Advanced MSI-high solid tumors that relapsed following PD-1/L-1 checkpoint inhibitor therapy | A Phase I/II Open-label Study of EDP1503 Alone and in Combination With Pembrolizumab in Patients With Advanced Metastatic Colorectal Carcinoma, Triple-negative Breast Cancer, and Checkpoint Inhibitor Relapsed Tumors | View Drugs | Florida, Oklahoma, Tennessee |
| EDP1503 | monoclonal microbial EDP1503 | | | Pembrolizumab | Keytruda, Lambrolizumab, SCH 900475, MK3475, MK-3475 | Blocks PD-L1/2 inhibition of T cells |
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| NCT03744468 | I/II | Advanced solid tumors | Phase 1-2 Study Investigating Safety, Tolerability, Pharmacokinetics and Preliminary Antitumor Activity of Anti-TIM-3 Monoclonal Antibody BGB-A425 in Combination With Anti-PD-1 Monoclonal Antibody Tislelizumab in Patients With Advanced Solid Tumors | View Drugs | Colorado, Pennsylvania |
| BGB-A425 | | Blocks TIM-3 inhibition of T cells | | Tislelizumab | anti-PD-1 monoclonal antibody BGB-A317 | Blocks PD-L1/2 inhibition of T cells |
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| NCT03729596 | I/II | Advanced solid tumors | A Phase 1/2, First-in-Human, Open-Label, Dose-Escalation Study of MGC018 (Anti-B7-H3 Antibody Drug Conjugate) Alone and in Combination With MGA012 (Anti-PD-1 Antibody) in Patients With Advanced Solid Tumors | View Drugs | Michigan, North Carolina, Virginia |
| MGA012 | anti-PD-1 monoclonal antibody MGA012, INCMGA00012 | Blocks PD-L1 inhibition of T cells | | MGC018 | A humanized anti-B7-H3 antibody conjugated to the vc- seco - DUocarmycin-hydroxyBenzamide-Azaindole (DUBA) 2 DNA alkylating payload | ADC: anti-B7-H3 + DNA alkylating agent (duocarmycin) |
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| NCT03157128 | I/II | Advanced solid tumors | A Phase 1/2 Study of Oral LOXO-292 in Patients With Advanced Solid Tumors, Including RET Fusion-Positive Solid Tumors, Medullary Thyroid Cancer, and Other Tumors With RET Activation (LIBRETTO-001) | View Drugs | Arizona, California, Colorado, Connecticut, Florida, Georgia, Illinois, Louisiana, Maryland, Massachusetts, Michigan, Minnesota, Missouri, Nevada, New York, North Carolina, Ohio, Oregon, Pennsylvania, Tennessee, Texas, Utah, Virginia, Wisconsin |
| LOXO-292 | RET kinase inhibitor LOXO-292 | RET-kinase inhibitor |
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| NCT03665285 | I/II | Advanced solid tumors | A Phase 1/2, Open-Label, Dose-Escalation, Safety and Tolerability Study of NC318 in Subjects With Advanced or Metastatic Solid Tumors | View Drugs | California, Connecticut, New Jersey, New York, Texas |
| NC318 | anti-S15 monoclonal antibody NC318, anti-Siglec-15 monoclonal antibody NC318 | Blocks tumor-associated macrophage stimulation of tumor growth |
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| NCT03459222 | I/II | Advanced solid tumors | A Phase 1/2 Study of Relatlimab (Anti-LAG-3 Monoclonal Antibody) Administered in Combination With Both Nivolumab (Anti-PD-1 Monoclonal Antibody) and BMS-986205 (IDO1 Inhibitor) or in Combination With Both Nivolumab and Ipilimumab (Anti-CTLA-4 Monoclonal Antibody) in Advanced Malignant Tumors | View Drugs | California, Colorado, Maryland, Missouri, Tennessee, Washington |
| BMS-986205 | | Inhibits IDO1 to stimulate immune response | | Ipilimumab | Anti-Cytotoxic T-Lymphocyte-Associated Antigen-4 Monoclonal Antibody, MDX-010, Yervoy | Blocks CTLA-4 inhibition of T cells | | Nivolumab | BMS-936558, ONO-4538, MDX-1106, Anti-PD-1 human mab MDX-1106, Opdivo | Blocks PD-L1/2 inhibition of T cells | | Relatlimab | BMS986016, Anti-LAG-3 monoclonal antibody BMS-986016, Anti-LAG-3 monoclonal antibody BMS-986016 | Blocks LAG-3 inhibition of T cells |
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| NCT03761914 | I/II | Recurrent or persistent WT1+ ovarian cancer | A Phase 1/2 Study of Galinpepimut-S in Combination With Pembrolizumab (MK 3475) in Patients With Selected Advanced Cancers | View Drugs | California, Florida, Texas |
| Galinpepimut-S | | Immune response against cancer expressing WT1 | | Pembrolizumab | Keytruda, Lambrolizumab, SCH 900475, MK3475, MK-3475 | Blocks PD-L1/2 inhibition of T cells |
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| NCT03767348 | I/II | Advanced solid tumor - intratumoral injection (in expansion) | An Open-Label, Multicenter, Phase 1/2 Study of RP1 as a Single Agent and in Combination With PD1 Blockade in Patients With Solid Tumors | View Drugs | Arizona, Connecticut, Florida, Kentucky, New Jersey, New York, Oregon, Tennessee, Texas, Utah, Wisconsin |
| Nivolumab | BMS-936558, ONO-4538, MDX-1106, Anti-PD-1 human mab MDX-1106, Opdivo | Blocks PD-L1/2 inhibition of T cells | | RP1 | oncolytic virus RP1, A genetically modified oncolytic viral strain of the herpes simplex type 1 (HSV-1) virus | Induces immune response and tumor cell lysis |
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| NCT03840200 | I/II | Recurrent ovarian cancer | A Phase Ib, Open-Label, Multicenter Study Evaluating the Safety and Efficacy of Ipatasertib in Combination With Rucaparib in Patients With Advanced Breast, Ovarian, or Prostate Cancer | View Drugs | California, Pennsylvania |
| Ipatasertib | GDC-0068, Akt Inhibitor GDC-0068, RG7440 | pan-AKT inhibitor | | Rucaparib | AG-014699, PF 01367338, CO-338, Rubraca | PARP inhibitor |
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| NCT03907852 | I/II | Advanced mesothelin+ solid tumors (inc ovarian expansion) | A Phase 1/2 Single Arm Open-Label Clinical Trial of TC-210 T Cells in Patients With Advanced Mesothelin-Expressing Cancer | View Drugs | Maryland, Tennessee, Texas |
| Cyclophosphamide | Sendoxan, Procytox, Ledoxina, Genoxal, Fosfaseron, Enduxan, Endoxana, Endoxan, Cytophosphan, Cyclostine, Cyclostin, CYCLO-cell, Cycloblastine, Cycloblastin, Cicloxal, Carloxan, Neosar, Cytoxan, Clafen, Zytoxan, Syklofosfamid, Mitoxan, Cytophosphane, Cyclophosphanum, Cyclophosphan, Cyclophosphamidum, Cyclophosphamid monohydrate, Cyclophospham, CPM, CP monohydrate, Claphene, Ciclofosfamide, Ciclofosfamida | DNA damaging agent | | Fludarabine | Fludara Oral, 2-F-ara-AMP, Beneflur | DNA synthesis inhibitor | | TC-210 T cells | TC-210 TruC-T cells | Immune response against cancer expressing mesothelin |
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| NCT04021043 | I/II | Advanced solid tumors (inc expansion) | Phase I/II Trial of Ipilimumab or Nivolumab With BMS-986156 and Hypofractionated Stereotactic Radiation Therapy in Patients With Advanced Solid Malignancies | View Drugs | Texas |
| BMS-986156 | | GITR (glucocorticoid-induced TNFR) agonist | | Ipilimumab | Anti-Cytotoxic T-Lymphocyte-Associated Antigen-4 Monoclonal Antibody, MDX-010, Yervoy | Blocks CTLA-4 inhibition of T cells | | Nivolumab | BMS-936558, ONO-4538, MDX-1106, Anti-PD-1 human mab MDX-1106, Opdivo | Blocks PD-L1/2 inhibition of T cells | | Radiation Therapy | Radiotherapy, Irradiation | |
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| NCT03997968 | I/II | Advanced solid tumors (inc expansion) | A Multi-Center, Open Label Phase 1/2 Study of CYT-0851, an Oral RAD51 Inhibitor, in Patients With Relapsed/Refractory B-Cell Malignancies and Advanced Solid Tumors | View Drugs | Colorado, Tennessee |
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| NCT03992131 | I/II | Advanced solid tumors (inc ovarian expansion) | SEASTAR: A Phase 1b/2, Open-label, Parallel Arm Study to Assess the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of Oral Rucaparib in Combination With Other Anticancer Agents in Patients With a Solid Tumor | View Drugs | Massachusetts, Tennessee, Texas |
| Lucitanib | VEGFR/FGFR dual kinase inhibitor E-3810 | VEGFR and FGFR kinase inhibitor | | Rucaparib | AG-014699, PF 01367338, CO-338, Rubraca | PARP inhibitor | | Sacituzumab Govitecan | anti-TROP-2 Antibody-Drug Conjugate IMMU-132, hrS7-SN38 antibody drug conjugate | ADC: Anti-TROP2 + topoisomerase I inhibitor |
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| NCT03994601 | I/II | Advanced solid tumors (inc expansion) | A Phase 1/2 First-in-human Study of BMS-986288 Alone and in Combination With Nivolumab in Advanced Malignant Tumors | View Drugs | Colorado, Maryland, Missouri, New Jersey |
| BMS-986288 | | Undisclosed mechanism | | Nivolumab | BMS-936558, ONO-4538, MDX-1106, Anti-PD-1 human mab MDX-1106, Opdivo | Blocks PD-L1/2 inhibition of T cells |
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| NCT04068194 | I/II | Advanced solid tumors | A Phase I/II Study of M3814 and Avelumab in Combination With Hypofractionated Radiation in Patients With Advanced/Metastatic Solid Tumors and Hepatobiliary Malignancies | View Drugs | Contact NCI |
| Avelumab | Anti programmed death ligand 1 monoclonal antibody, Anti-PD-L1, MSB0010718C, Bavencio | Blocks PD-L1 inhibition of T cells | | M3814 | DNA-PK inhibitor MSC2490484A, Nedisertib | DNA-PK inhibitor | | Radiation Therapy | Radiotherapy, Irradiation | |
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| NCT03138083 | I/II | Advanced solid tumors with MET alterations | A Modular, Multi-arm, Multi-part, First Time in Patient Study to Evaluate the Safety and Tolerability of OMO-1, Alone and in Combination With Anti-cancer Treatments, in Patients With Locally Advanced, Unresectable or Metastatic Solid Malignancies | View Drugs | Texas |
| OMO-1 | MET kinase inhibitor OMO-1, JNJ-38877618 | c-Met kinase inhibitor |
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| NCT04104776 | I/II | Advanced solid tumors (inc expansion) | A Phase 1/2 Study of CPI-0209 Monotherapy and in Combination With Other Therapy in Patients With Advanced Solid Tumors | View Drugs | Michigan, New Jersey, Texas |
| CPI-0209 | | EZH2 histone methyltransferase inhibitor | | Irinotecan | Campothecin-11, Campto, Camptosar | Topoisomerase I inhibitor |
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| NCT03711058 | I/II | Advanced solid tumors with low MSI | A Phase I/II Study of PI3Kinase Inhibition (Copanlisib) and Anti-PD-1 Antibody Nivolumab in Relapsed/Refractory Solid Tumors With Expansions in Mismatch-repair Proficient (MSS) Colorectal Cancer | View Drugs | Maryland |
| Copanlisib | BAY 80-6946, MEK inhibitor BAY 80-6946, PI3K inhibitor BAY 80-6946 | pan-PI3K inhibitor | | Nivolumab | BMS-936558, ONO-4538, MDX-1106, Anti-PD-1 human mab MDX-1106, Opdivo | Blocks PD-L1/2 inhibition of T cells |
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| NCT03785249 | I/II | Advanced solid tumors with KRAS G12C mutation (inc expansion) | A Phase 1/2 Multiple Expansion Cohort Trial of MRTX849 in Patients With Advanced Solid Tumors With KRAS G12C Mutation | View Drugs | California, Massachusetts, Michigan, New York, Tennessee, Texas, Wisconsin |
| MRTX849 | KRAS G12C inhibitor MRTX849 | KRAS G12C inhibitor |
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| NCT03884556 | I/Ib | Advanced solid tumors (inc expansion) | Phase 1/1b Study of the Safety of TTX-030 as a Single Agent and in Combination With Pembrolizumab or Chemotherapy in Patients With Lymphoma or Solid Tumor Malignancies | View Drugs | Florida, Tennessee, Texas, Utah |
| Docetaxel | Taxotere | Microtubule stabilizer/mitotic inhibitor | | Pembrolizumab | Keytruda, Lambrolizumab, SCH 900475, MK3475, MK-3475 | Blocks PD-L1/2 inhibition of T cells | | TTX-030 | anti-CD39 monoclonal antibody | Inhibits the breakdown of ATP by CD39 |
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| NCT02660034 | I/Ib | Platinum sensitive or partially sensitive ovarian cancer (at least 2 prior platinum therapies, in expansion) | A Phase 1/1b, Open Label, Multiple Dose, Dose Escalation and Expansion Study to Investigate the Safety, Pharmacokinetics and Antitumor Activity of the Anti-PD-1 Monoclonal Antibody BGB-A317 in Combination With the PARP Inhibitor BGB-290 in Subjects With Advanced Solid Tumors | View Drugs | Arizona, California, Colorado, Florida, Massachusetts, Tennessee, Texas, Virginia |
| Pamiparib | PARP inhibitor BGB-290 | PARP inhibitor | | Tislelizumab | anti-PD-1 monoclonal antibody BGB-A317 | Blocks PD-L1/2 inhibition of T cells |
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| NCT03511222 | I | Advanced solid tumors with high MSI | A Phase IB Trial of Vorolanib (X-82) Combined With Checkpoint Inhibitors in Patients With Solid Tumors | View Drugs | Missouri |
| Nivolumab | BMS-936558, ONO-4538, MDX-1106, Anti-PD-1 human mab MDX-1106, Opdivo | Blocks PD-L1/2 inhibition of T cells | | Pembrolizumab | Keytruda, Lambrolizumab, SCH 900475, MK3475, MK-3475 | Blocks PD-L1/2 inhibition of T cells | | Vorolanib | CM-082, X-82 | VEGFR and PDGFR kinase inhibitor |
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| NCT01417546 | I | Advanced solid tumors (in expansion) | First In-Human Phase I Trial of NHS-IL12 in Patients With Metastatic Solid Tumors | View Drugs | Maryland |
| NHS-IL12 | M9241, immunocytokine NHS-IL12 | IL-12 receptor agonist |
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| NCT03435250 | I | Advanced solid tumors with CDKN2A deletion (inc expansion) | A Phase 1 Study of AG-270 in the Treatment of Subjects With Advanced Solid Tumors or Lymphoma With Homozygous Deletion of MTAP | View Drugs | Connecticut, Massachusetts, New York, Tennessee |
| AG-270 | | Methionine adenosyltransferase 2a (MAT2A) inhibitor |
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| NCT02675439 | I | Advanced solid tumors - intratumoral injection | A Phase I, Open Label, Multicenter Study of the Safety and Efficacy of MIW815 (ADU-S100) Administered by Intratumoral Injection to Patients With Advanced/Metastatic Solid Tumors or Lymphomas | View Drugs | Colorado, Illinois, Massachusetts, New York, Texas, Utah |
| ADU-S100 | CDN agonist ADU-S100, MIW815, STING-activating cyclic dinucleotide agonist ADU-S100 | Activates STING to stimulate immune cell activation | | Ipilimumab | Anti-Cytotoxic T-Lymphocyte-Associated Antigen-4 Monoclonal Antibody, MDX-010, Yervoy | Blocks CTLA-4 inhibition of T cells |
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| NCT03059823 | I | Advanced solid tumors (inc expansion) | A Phase 1 Study of the Safety, Tolerability, and Pharmacokinetics of INCMGA00012 in Patients With Advanced Solid Tumors | View Drugs | Arizona, Michigan, New Jersey, North Carolina, Texas, Virginia |
| MGA012 | anti-PD-1 monoclonal antibody MGA012, INCMGA00012 | Blocks PD-L1 inhibition of T cells |
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| NCT03431948 | I | Advanced solid tumors (amenable to radiation therapy) | Platform Phase 1 Study Investigating the Safety of Stereotactic Body Radiotherapy (SBRT) With Immuno-oncology Agents for the Treatment of Multiple Metastases in Advanced Solid Tumors | View Drugs | Illinois |
| Cabiralizumab | anti-CSF1R monoclonal antibody FPA008, FPA008 | CSF1R antagonist and tumor-associated macrophage inhibitor | | Nivolumab | BMS-936558, ONO-4538, MDX-1106, Anti-PD-1 human mab MDX-1106, Opdivo | Blocks PD-L1/2 inhibition of T cells | | Radiation Therapy | Radiotherapy, Irradiation | | | Urelumab | BMS-663513, anti-CD137 monoclonal antibody, anti-4-1BB monoclonal antibody | Stimulates 4-1BB (CD137) to increase T cells and immune response |
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| NCT03335540 | I | Advanced solid tumors | ADaptiVe Biomarker Trial That InformS Evolution of Therapy | View Drugs | Illinois, Pennsylvania |
| BMS-986205 | | Inhibits IDO1 to stimulate immune response | | Cabiralizumab | anti-CSF1R monoclonal antibody FPA008, FPA008 | CSF1R antagonist and tumor-associated macrophage inhibitor | | Ipilimumab | Anti-Cytotoxic T-Lymphocyte-Associated Antigen-4 Monoclonal Antibody, MDX-010, Yervoy | Blocks CTLA-4 inhibition of T cells | | Nivolumab | BMS-936558, ONO-4538, MDX-1106, Anti-PD-1 human mab MDX-1106, Opdivo | Blocks PD-L1/2 inhibition of T cells | | Relatlimab | BMS986016, Anti-LAG-3 monoclonal antibody BMS-986016, Anti-LAG-3 monoclonal antibody BMS-986016 | Blocks LAG-3 inhibition of T cells |
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| NCT03144661 | I | Recurrent advanced serous ovarian cancer | A Phase 1, Open-Label, Dose-Escalation and Expansion, Safety and Tolerability Study of INCB062079 in Subjects With Advanced Hepatocellular Carcinoma and Other Malignancies | View Drugs | Alabama, New York |
| INCB062079 | | FGFR4 inhibitor |
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| NCT03154294 | I | Advanced solid tumors | A Phase 1 Evaluation of the Safety and Tolerability of TAK-228 in Combination With TAK-117 and Paclitaxel in Advanced Solid Tumors | View Drugs | South Dakota |
| MLN1117 | INK-1117, TAK-117, PI3K alpha inhibitor MLN1117, Serabelisib | PI3K alpha inhibitor | | Paclitaxel | Anzatax, Asotax, Bristaxol, Praxel, Taxol, Taxol Konzentrat, TXL | Microtubule stabilizer/mitotic inhibitor | | Sapanisertib | INK128, TORC1/2 Inhibitor INK128, TORC1/2 Inhibitor MLN0128, MLN0128, TAK-228 | TORC1/2 kinase inhibitor |
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| NCT03213964 | I | Recurrent advanced ovarian cancer only in abdomen/pelvis | Intraperitoneal Delivery of Adaptive Natural Killer (NK) Cells (FATE-NK100) With Intraperitoneal Interleukin-2 in Women With Recurrent Ovarian, Fallopian Tube, and Primary Peritoneal Cancer | View Drugs | Minnesota |
| FATE-NK100 | NKG2C/CD57-expressing adaptive memory natural killer cells FATE-NK100 | Anti-tumor immune response |
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| NCT03319459 | I | Advanced solid tumors, including HER2+ or EGFR+ tumors | FATE-NK100 as Monotherapy and in Combination With Monoclonal Antibody in Subjects With Advanced Solid Tumors | View Drugs | California, Minnesota, Ohio, Texas |
| Cetuximab | Erbitux, Anti-EGFR Monoclonal Antibody, Chimeric MoAb C225 | EGFR antagonist | | FATE-NK100 | NKG2C/CD57-expressing adaptive memory natural killer cells FATE-NK100 | Anti-tumor immune response | | Trastuzumab | Herceptin, Anti-erbB2 Monoclonal Antibody, HER2 Monoclonal Antibody | HER2 antagonist |
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| NCT03310541 | I | Advanced solid tumors with AKT1, AKT2, or AKT3 mutations | A Pilot Study of AZD5363 for Patients With Advanced Solid Tumors Harboring Mutations in AKT1, AKT2, or AKT3 | View Drugs | New Jersey, New York |
| Capivasertib | Akt inhibitor AZD5363 | pan-AKT inhibitor |
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| NCT02715284 | I | Advanced solid tumors (inc expansion) | A Phase 1 Dose Escalation and Cohort Expansion Study of TSR-042, an Anti-PD-1 Monoclonal Antibody, in Patients With Advanced Solid Tumors | View Drugs | Alabama, Arizona, Arkansas, California, District of Columbia, Florida, Georgia, Illinois, Kansas, Maine, Massachusetts, Michigan, Missouri, New Mexico, New York, North Carolina, Ohio, Oklahoma, Oregon, Pennsylvania, Rhode Island, Tennessee, Texas, Utah, Virginia, Washington, West Virginia, Wisconsin |
| Dostarlimab | ANB011, anti-PD-1 monoclonal antibody TSR-042, TSR-042 | Blocks PD-L1/2 inhibition of T cells |
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| NCT03313778 | I | Advanced solid tumors with high MSI or high TMB (in expansion) | A Phase 1, Open-Label, Multicenter Study to Assess the Safety, Tolerability, and Immunogenicity of mRNA-4157 Alone in Subjects With Resected Solid Tumors and in Combination With Pembrolizumab in Subjects With Unresectable Solid Tumors | View Drugs | Florida, Massachusetts, New Jersey, New York, North Carolina, Tennessee |
| mRNA-4157 | mRNA-based personalized cancer vaccine mRNA-4157 | Anti-tumor immune response | | Pembrolizumab | Keytruda, Lambrolizumab, SCH 900475, MK3475, MK-3475 | Blocks PD-L1/2 inhibition of T cells |
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| NCT02611024 | I | Advanced solid tumors (inc expansion) | Phase I, Multicenter, Open-label, Clinical and Pharmacokinetic Study of PM01183 in Combination With Irinotecan in Pretreated Patients With Selected Advanced Solid Tumors | View Drugs | Massachusetts |
| Irinotecan | Campothecin-11, Campto, Camptosar | Topoisomerase I inhibitor | | Lurbinectedin | PM01183 | |
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| NCT03192345 | I | Advanced solid tumors | A Phase 1/1b First-in-human Dose Escalation and Expansion Study for the Evaluation of Safety, Pharmacokinetics, Pharmacodynamics, and Anti-tumor Activity of SAR439459 Administered Intravenously as Monotherapy and in Combination With Cemiplimab in Adult Patients With Advanced Solid Tumors | View Drugs | California, Kansas, Massachusetts, Tennessee, Texas |
| Cemiplimab | anti-PD-1 monoclonal antibody REGN2810, anti-PD-1 monoclonal antibody REGN2810 | Blocks PD-L1/2 inhibition of T cells | | SAR439459 | anti-TGF-beta monoclonal antibody SAR-439459 | TGFbeta antagonist |
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| NCT02937272 | I | Advanced solid tumors (inc expansion) | A Phase 1 Study of LY3200882 in Patients With Solid Tumors | View Drugs | California, Kentucky, New York, Texas |
| Cisplatin | CACP, cis-DDP, cis-platinum, CDDP, Platinol, Abiplatin, Blastolem, Briplatin, Cisplatyl, Citoplatino, Citosin, Lederplatin, Metaplatin, Neoplatin, Placis, Platamine, Platiblastin, Platiblastin-S, Platinex, Platinol, Platiran, Platistin, Platosin | DNA damaging agent | | Gemcitabine | Gemzar | Ribonucleotide reductase and DNA synthesis inhibitor | | LY3200882 | TGFbeta inhibitor LY3200882, TGFb inhibitor LY 3200882 | TGFbeta antagonist | | LY3300054 | | Blocks PD-L1 inhibition of T cells | | nab-Paclitaxel | Paclitaxel Albumin-Stabilized Nanoparticle Formula, Abraxane, ABI-007 | Microtubule stabilizer/mitotic inhibitor |
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| NCT03289962 | I | Advanced solid tumors | A Phase 1a/1b Open-Label, Dose-Escalation Study of the Safety and Pharmacokinetics of RO7198457 as a Single Agent and in Combination With Atezolizumab in Patients With Locally Advanced or Metastatic Tumors | View Drugs | Arizona, California, Colorado, Connecticut, District of Columbia, Massachusetts, Nevada, New York, Oklahoma, Oregon, Tennessee, Washington |
| Atezolizumab | Tecentriq, Anti-PD-L1 Monoclonal Antibody MPDL3280A, MPDL3280A, RG7446 | Blocks PD-L1 inhibition of T cells | | RO7198457 | personalized cancer vaccine RO7198457, PCV RO7198457 | Immune response against tumor-associated antigens |
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| NCT03229278 | I | Advanced solid tumors with high MSI | A Phase I Study to Evaluate the Safety of Trigriluzole (FC-4157/BHV-4157) in Combination With PD-1 Blocking Antibodies | View Drugs | New Jersey |
| Nivolumab | BMS-936558, ONO-4538, MDX-1106, Anti-PD-1 human mab MDX-1106, Opdivo | Blocks PD-L1/2 inhibition of T cells | | Pembrolizumab | Keytruda, Lambrolizumab, SCH 900475, MK3475, MK-3475 | Blocks PD-L1/2 inhibition of T cells | | Trigriluzole | BHV-4157, FC-4157 | Glutamate antagonist |
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| NCT01434316 | I | Advanced solid tumors including those with BRCA1/2 mutations (in expansion) | Phase 1 Trial of ABT-888 and SCH727965 in Patients With Advanced Solid Tumors | View Drugs | Massachusetts |
| Dinaciclib | SCH 727965, CDK inhibitor SCH 727965 | CDK1, 2, 5, 9 inhibitor | | Veliparib | ABT-888 | PARP inhibitor |
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| NCT02503774 | I | Advanced solid tumors (in expansion) | A Phase 1 Multicenter, Open-label, Dose-escalation and Dose-expansion Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Immunogenicity, and Antitumor Activity of MEDI9447 Alone and in Combination With MEDI4736 in Adult Subjects With Select Advanced Solid Tumors | View Drugs | California, Connecticut, Florida, Georgia, Missouri, North Carolina, Ohio, Tennessee, Texas |
| Durvalumab | Anti-B7H1 Monoclonal Antibody MEDI4736, MEDI4736, Imfinzi | Blocks PD-L1 inhibition of T cells | | Oleclumab | anti-CD73 monoclonal antibody MEDI9447 | Blocks Ecto-5-nucleotidase (CD73) inhibition of T cells |
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| NCT02627443 | I | Platinum sensitive ovarian cancer at first or second recurrence | Phase 1 Dose Escalation and Expansion Cohort of Carboplatin and Gemcitabine With or Without M6620 (VX-970) in First or Second Recurrence Platinum-Sensitive Epithelial Ovarian, Peritoneal, and Fallopian Tube Cancer | View Drugs | Arizona, Florida, Kentucky, Minnesota, Missouri, Pennsylvania, Virginia |
| Berzosertib | M6620, VE-822, ATR kinase inhibitor VX-970, ATR kinase inhibitor VX-970 | ATR kinase inhibitor | | Carboplatin | Paraplatin, Novoplatinum | DNA damaging agent | | Gemcitabine | Gemzar | Ribonucleotide reductase and DNA synthesis inhibitor |
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| NCT02433626 | I | Recurrent ovarian cancer | A Phase 1 Study of COTI-2 as Monotherapy or Combination Therapy for the Treatment of Advanced or Recurrent Malignancies | View Drugs | Texas |
| Cisplatin | CACP, cis-DDP, cis-platinum, CDDP, Platinol, Abiplatin, Blastolem, Briplatin, Cisplatyl, Citoplatino, Citosin, Lederplatin, Metaplatin, Neoplatin, Placis, Platamine, Platiblastin, Platiblastin-S, Platinex, Platinol, Platiran, Platistin, Platosin | DNA damaging agent | | COTI-2 | mutant p53 activator COTI-2 | Mutant p53 activator |
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| NCT02534922 | I | Recurrent or persistent ovarian cancer | Phase I Open-Label, Dose-Escalation and Pharmacokinetic Study of Subcutaneous Prolanta™ in Subjects With Recurrent or Persistent Epithelial Ovarian Cancer, Primary Peritoneal Cancer, or Fallopian Tube Cancer | View Drugs | South Carolina |
| Prolanta | | Prolactin receptor antagonist |
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| NCT02791334 | I | Advanced solid tumors (in expansion) | A Phase 1a/1b Study of a Novel Anti-PD-L1 Checkpoint Antibody (LY3300054) Administered Alone or in Combination With Other Agents in Advanced Refractory Solid Tumors (Phase 1a/1b Anti-PD-L1 Combinations in Tumors-PACT) | View Drugs | Tennessee, Texas |
| LY3300054 | | Blocks PD-L1 inhibition of T cells | | LY3321367 | anti-TIM3 monoclonal antibody LY3321367 | Blocks TIM-3 inhibition of T cells | | Ramucirumab | anti-VEGFR-2 fully human monoclonal antibody IMC-1121B, IMC-1121B, LY3009806 | VEGFR2 antagonist |
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| NCT02897375 | I | Advanced solid tumors | A Phase 1 Study of Palbociclib in Combination With Cisplatin or Carboplatin in Advanced Solid Malignancies | View Drugs | Georgia |
| Carboplatin | Paraplatin, Novoplatinum | DNA damaging agent | | Cisplatin | CACP, cis-DDP, cis-platinum, CDDP, Platinol, Abiplatin, Blastolem, Briplatin, Cisplatyl, Citoplatino, Citosin, Lederplatin, Metaplatin, Neoplatin, Placis, Platamine, Platiblastin, Platiblastin-S, Platinex, Platinol, Platiran, Platistin, Platosin | DNA damaging agent | | Palbociclib | PD-0332991, PD0332991, Ibrance | CDK4/6 inhibitor |
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| NCT01376505 | I | Advanced solid tumors (in ovarian expansion) | Phase I Active Immunotherapy Trial With a Combination of Two Chimeric (Trastuzumab-like and Pertuzumab-like)Human Epidermal Growth Factor Receptor 2 (HER-2) B Cell Peptide Vaccine Emulsified in ISA 720 and Nor-MDP Adjuvant in Patients With Advanced Solid Tumors | View Drugs | Ohio |
| MVF-HER-2(597-626)-MVF-HER-2 (266-296) peptide vaccine | | Immune response against cancer expressing HER2 |
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| NCT02498912 | I | MUC16+ recurrent high grade serous ovarian cancer (> 2 prior therapies) | A Phase I Clinical Trial of Cyclophosphamide Followed by Intravenous and Intraperitoneal Infusion of Autologous T Cells Genetically Engineered to Secrete IL-12 and to Target the MUC16ecto Antigen in Patients With Recurrent MUC16ecto+ Solid Tumors | View Drugs | New York |
| 4H11-28z/fIL-12/EFGRt-expressing autologous T lymphocytes | 4H11-28z/fIL-12/EFGRt+ genetically-modified T cells, autologous MUC16ecto-targeting EGFR-secreting T lymphocytes | Immune response against cancer expressing CA125 | | Cyclophosphamide | Sendoxan, Procytox, Ledoxina, Genoxal, Fosfaseron, Enduxan, Endoxana, Endoxan, Cytophosphan, Cyclostine, Cyclostin, CYCLO-cell, Cycloblastine, Cycloblastin, Cicloxal, Carloxan, Neosar, Cytoxan, Clafen, Zytoxan, Syklofosfamid, Mitoxan, Cytophosphane, Cyclophosphanum, Cyclophosphan, Cyclophosphamidum, Cyclophosphamid monohydrate, Cyclophospham, CPM, CP monohydrate, Claphene, Ciclofosfamide, Ciclofosfamida | DNA damaging agent | | Fludarabine | Fludara Oral, 2-F-ara-AMP, Beneflur | DNA synthesis inhibitor |
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| NCT02829723 | I | Advanced solid tumors | A Phase I/II, Open-label, Multi-center Study of the Safety and Efficacy of BLZ945 as Single Agent and in Combination With PDR001 in Adults Patients With Advanced Solid Tumors | View Drugs | Tennessee, Texas |
| BLZ945 | CSF-1R inhibitor BLZ945 | CSF1R antagonist and tumor-associated macrophage inhibitor | | Spartalizumab | anti-PD-1 monoclonal antibody PDR001, PDR001 | Blocks PD-L1/2 inhibition of T cells |
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| NCT03017131 | I | Recurrent or refractory ovarian cancer | A Phase I Open Label Clinical Trial Evaluating the Safety and Efficacy of Adoptive Transfer of NY-ESO-1 TCR Engineered Autologous T Cells in Combination With Decitabine in Patients With Recurrent or Treatment Refractory Ovarian Cancer | View Drugs | New York |
| Cyclophosphamide | Sendoxan, Procytox, Ledoxina, Genoxal, Fosfaseron, Enduxan, Endoxana, Endoxan, Cytophosphan, Cyclostine, Cyclostin, CYCLO-cell, Cycloblastine, Cycloblastin, Cicloxal, Carloxan, Neosar, Cytoxan, Clafen, Zytoxan, Syklofosfamid, Mitoxan, Cytophosphane, Cyclophosphanum, Cyclophosphan, Cyclophosphamidum, Cyclophosphamid monohydrate, Cyclophospham, CPM, CP monohydrate, Claphene, Ciclofosfamide, Ciclofosfamida | DNA damaging agent | | Decitabine | 5-aza-dCyd, deoxyazacytidine, dezocitidine, Dacogen | DNA methylation inhibitor | | Genetically Engineered NY-ESO-1-specific T Lymphocytes | | Immune response against cancer expressing NY-ESO-1 |
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| NCT03030378 | I | Advanced solid tumors | A Phase 1 Study of MK-3475 (Pembrolizumab) in Combination With Recombinant Interleukin-12 in Patients With Solid Tumors | View Drugs | California, Colorado, Connecticut, Florida, Georgia, Iowa, Maryland, Massachusetts, Missouri, New Jersey, North Carolina, Ohio, Pennsylvania, Virginia |
| IL-12 | cytotoxic lymphocyte maturation factor interleukin-12, Ro 24-7472, recombinant interleukin-12, natural killer cell stimulatory factor NM-IL-12 | IL-12 receptor agonist | | Pembrolizumab | Keytruda, Lambrolizumab, SCH 900475, MK3475, MK-3475 | Blocks PD-L1/2 inhibition of T cells |
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| NCT02972034 | I | Advanced solid tumors | A Phase Ib Study to Evaluate the Safety and Tolerability of MK-8353 in Combination With Pembrolizumab in Patients With Advanced Malignancies | View Drugs | Michigan, Tennessee |
| MK-8353 | ERK1 inhibitor MK-8353 | ERK inhibitor | | Pembrolizumab | Keytruda, Lambrolizumab, SCH 900475, MK3475, MK-3475 | Blocks PD-L1/2 inhibition of T cells |
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| NCT03069469 | I | Advanced solid tumors (in expansion) | Multi-center, Phase 1, Open-Label Study of DCC-3014 to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics in Patients With Advanced Tumors | View Drugs | California, Colorado, Florida, New York, Oregon, Tennessee |
| DCC-3014 | | CSF1R kinase inhibitor |
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| NCT03018405 | I | Advanced solid tumors (in expansion) | A Multi-national, Open-label, Dose Escalation Phase I Study to Assess the Safety and Clinical Activity of Multiple Administrations of NKR-2 in Patients With Different Metastatic Tumor Types (THINK - THerapeutic Immunotherapy With NKR-2) | View Drugs | Florida, New York |
| NKR-2 | autologous NKG2D CAR-CD3zeta-DAP10-expressing T lymphocytes CYAD-01 | Immune response against cancer expressing NKG2D-L |
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| NCT03054298 | I | Recurrent or persistent mesothelin+ serous ovarian cancer | Phase I Study of Human Chimeric Antigen Receptor Modified T Cells in Patients With Mesothelin Expressing Cancers | View Drugs | Pennsylvania |
| Cyclophosphamide | Sendoxan, Procytox, Ledoxina, Genoxal, Fosfaseron, Enduxan, Endoxana, Endoxan, Cytophosphan, Cyclostine, Cyclostin, CYCLO-cell, Cycloblastine, Cycloblastin, Cicloxal, Carloxan, Neosar, Cytoxan, Clafen, Zytoxan, Syklofosfamid, Mitoxan, Cytophosphane, Cyclophosphanum, Cyclophosphan, Cyclophosphamidum, Cyclophosphamid monohydrate, Cyclophospham, CPM, CP monohydrate, Claphene, Ciclofosfamide, Ciclofosfamida | DNA damaging agent | | Hu-CART-meso cells | | Immune response against cancer expressing mesothelin |
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| NCT03154281 | I | Advanced ovarian cancer (no prior PARPi) | A Phase 1 Evaluation of the Safety and Tolerability of Niraparib in Combination With Everolimus in Advanced Ovarian and Breast Cancer | View Drugs | South Dakota |
| Everolimus | Afinitor, Certican, RAD001, Zortress | mTOR inhibitor | | Niraparib | MK4827, Zejula | PARP inhibitor |
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| NCT03056833 | I | Platinum sensitive recurrent ovarian cancer | Phase I Trial of Ribociclib (Ribociclib (LEE-011)) With Platinum-based Chemotherapy in Recurrent Platinum Sensitive Ovarian Cancer | View Drugs | Pennsylvania |
| Carboplatin | Paraplatin, Novoplatinum | DNA damaging agent | | Paclitaxel | Anzatax, Asotax, Bristaxol, Praxel, Taxol, Taxol Konzentrat, TXL | Microtubule stabilizer/mitotic inhibitor | | Ribociclib | Kisqali, CDK4/6 Inhibitor LEE011, LEE011, Kisqali | CDK4/6 inhibitor |
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| NCT03023319 | I | Advanced solid tumors | Phase I Study of the Non-receptor Kinase Inhibitor Bosutinib in Combination With Pemetrexed in Patients With Selected Metastatic Solid Tumors | View Drugs | Ohio |
| Bosutinib | Bosulif, SKI-606 | Abl and src family kinase inhibitor | | Pemetrexed | Pemetrexed disodium, Alimta | DHFR and Thymidylate synthase inhibitor |
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| NCT03894540 | I | Advanced solid tumors (inc expansion) | A Phase I, Open Label, Dose Escalation and Dose Expansion Study to Investigate the Safety, Pharmacokinetics, Pharmacodynamics and Anti-tumour Activity of IPN60090 as Single Agent and in Combination in Patients With Advanced Solid Tumours | View Drugs | Texas |
| IPN60090 | | Undisclosed mechanism | | Paclitaxel | Anzatax, Asotax, Bristaxol, Praxel, Taxol, Taxol Konzentrat, TXL | Microtubule stabilizer/mitotic inhibitor | | Pembrolizumab | Keytruda, Lambrolizumab, SCH 900475, MK3475, MK-3475 | Blocks PD-L1/2 inhibition of T cells |
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| NCT03893955 | I | Advanced solid tumors | A Phase 1, Multicenter, Open-Label Study to Determine the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of ABBV-927 and ABBV-368 With and Without ABBV-181 in Subjects With Locally Advanced or Metastatic Solid Tumors | View Drugs | Alabama, California, Connecticut, North Carolina, Texas, Virginia |
| ABBV-368 | | Stimulates OX40 to increase T cell activation and immune response | | ABBV-927 | anti-CD40 agonist monoclonal antibody ABBV-927 | Stimulates CD40 to increase/activate antigen-presenting cells and enhance immune response |
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| NCT03628677 | I | Advanced solid tumors (inc expansion) | A Phase 1 Study to Evaluate the Safety and Tolerability of AB154 Monotherapy and Combination Therapy in Participants With Advanced Malignancies | View Drugs | California, North Carolina, Texas, Washington |
| AB122 | anti-PD-1 monoclonal antibody AB122 | Blocks PD-L1 inhibition of T cells | | AB154 | | Blocks T cell binding to CD112 and CD155 to enable activation of CD226 signaling in NK and CD8 T cells |
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| NCT03920839 | I | Advanced solid tumors at first recurrence | A Phase 1b Combination Study of INCMGA00012 Plus Chemotherapy in Participants With Advanced Solid Tumors (POD1UM-105) | View Drugs | California, Delaware |
| Carboplatin | Paraplatin, Novoplatinum | DNA damaging agent | | Cisplatin | CACP, cis-DDP, cis-platinum, CDDP, Platinol, Abiplatin, Blastolem, Briplatin, Cisplatyl, Citoplatino, Citosin, Lederplatin, Metaplatin, Neoplatin, Placis, Platamine, Platiblastin, Platiblastin-S, Platinex, Platinol, Platiran, Platistin, Platosin | DNA damaging agent | | Gemcitabine | Gemzar | Ribonucleotide reductase and DNA synthesis inhibitor | | MGA012 | anti-PD-1 monoclonal antibody MGA012, INCMGA00012 | Blocks PD-L1 inhibition of T cells | | Paclitaxel | Anzatax, Asotax, Bristaxol, Praxel, Taxol, Taxol Konzentrat, TXL | Microtubule stabilizer/mitotic inhibitor | | Pemetrexed | Pemetrexed disodium, Alimta | DHFR and Thymidylate synthase inhibitor |
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| NCT02743637 | I | Advanced solid tumors | A Phase 1 Dose Escalation Study of SDX-7320 to Assess the Safety and Tolerability in Patients With Advanced Refractory or Late-Stage Solid Tumors | View Drugs | Arizona, California, Tennessee |
| SDX-7320 | methionine aminopeptidase type II inhibitor SDX-7320, MetAP2 inhibitor SDX-7320 | Angiogenesis inhibitor |
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| NCT03934814 | I | Advanced solid tumors (inc ovarian expansion) | A Phase 1 Study of TJ011133 Administered Alone or in Combination With Pembrolizumab or Rituximab in Subjects With Relapsed/Refractory Advanced Solid Tumors and Lymphoma | View Drugs | Alabama, Arizona, California, Connecticut, Florida, Indiana, Michigan, Minnesota, New York, Tennessee, Washington |
| Pembrolizumab | Keytruda, Lambrolizumab, SCH 900475, MK3475, MK-3475 | Blocks PD-L1/2 inhibition of T cells | | TJ011133 | TJC4 | Blocks CD47 signaling to stimulate immune response and tumor cell phagocytosis |
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| NCT03946800 | I | Advanced solid tumors (inc expansion) - intratumoral injection | A Phase 1, Open-label, Dose-escalation and Expansion Study of MEDI1191 Administered Intratumorally as Monotherapy and in Combination With Durvalumab in Subjects With Advanced Solid Tumors | View Drugs | Arizona, California, Illinois, New York, Rhode Island, Texas, Washington |
| Durvalumab | Anti-B7H1 Monoclonal Antibody MEDI4736, MEDI4736, Imfinzi | Blocks PD-L1 inhibition of T cells | | MEDI1191 | IL-12 mRNA, lipid nanoparticle encapsulating mRNA encoding human IL-12 | IL-12 receptor agonist |
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| NCT03956680 | I | Advanced solid tumors - optional intratumoral injection | A Phase I Study of BMS-986301 Monotherapy and Combination Therapy With Nivolumab and Ipilimumab in Participants With Advanced Solid Cancers | View Drugs | Illinois, Maryland, Missouri, Pennsylvania, Texas |
| BMS-986301 | differentiated STING agonist, Small molecule STING agonist | Activates STING to stimulate immune cell activation | | Ipilimumab | Anti-Cytotoxic T-Lymphocyte-Associated Antigen-4 Monoclonal Antibody, MDX-010, Yervoy | Blocks CTLA-4 inhibition of T cells | | Nivolumab | BMS-936558, ONO-4538, MDX-1106, Anti-PD-1 human mab MDX-1106, Opdivo | Blocks PD-L1/2 inhibition of T cells |
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| NCT03444714 | I | Advanced solid tumors (with lesion amenable to palliative radiation therapy) - intratumoral injection | Phase I Dose-Escalating Study of RiMO-301 With Radiation in Advanced Tumors | View Drugs | Illinois |
| Radiation Therapy | Radiotherapy, Irradiation | | | RiMO-301 | MOF compound RiMO-301, metal-organic framework (MOF) compound RiMO-301 | Induces ROS-mediated DNA damage (following intratumoral injection and radiation) |
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| NCT03423628 | I | Advanced solid tumors with brain metastases not eligible for Stereotactic Radiosurgery (SRS) treatment | A Phase I, Multicentre Study to Assess the Safety, Tolerability, and Pharmacokinetics of Ascending Doses of AZD1390 in Combination With Radiation Therapy in Patients With Glioblastoma Multiforme and Brain Metastases From Solid Tumors | View Drugs | Massachusetts, New York, Pennsylvania, Virginia |
| AZD1390 | brain-penetrant ATM inhibitor AZD1390 | ATM kinase inhibitor | | Radiation Therapy | Radiotherapy, Irradiation | |
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| NCT03925428 | I | Advanced solid tumors | Phase I Study of GSK525762C and Entinostat in Advanced and Refractory Solid Tumors and Lymphomas | View Drugs | Contact NCI |
| Entinostat | HDAC inhibitor SNDX-275, MS 275, SNDX-275 | HDAC inhibitor | | Molibresib | BET inhibitor GSK525762, I-BET762 | BET inhibitor |
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| NCT03928314 | I | Advanced solid tumors (inc expansion) | An Open-label Phase 1b Study of ORIC-101 in Combination With Anticancer Therapy in Patients With Advanced or Metastatic Solid Tumors | View Drugs | California, Texas, Virginia |
| nab-Paclitaxel | Paclitaxel Albumin-Stabilized Nanoparticle Formula, Abraxane, ABI-007 | Microtubule stabilizer/mitotic inhibitor | | ORIC-101 | | GR antagonist |
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| NCT03240861 | I | Advanced NY-ESO-1+ solid tumors | Adoptive Transfer of NY-ESO-1 TCR Engineered Peripheral Blood Mononuclear Cells (PBMC) and Peripheral Blood Stem Cells (PBSC) After a Myeloablative Conditioning Regimen, With Administration of Interleukin-2, in Patients With Advanced Malignancies | View Drugs | California |
| Aldesleukin | | IL-2 receptor agonist | | Busulfan | Busulfex, busulphan, CB-2041, Glyzophrol, GT-41, joacamine, leucosulfan, mielucin, misulban, misulfan, mitosan, myeleukon, myeloleukon, myelosan, mylecytan, myleran, sulfabutin, WR-19508 | DNA damaging agent | | Fludarabine | Fludara Oral, 2-F-ara-AMP, Beneflur | DNA synthesis inhibitor | | NY-ESO-1 TCR transgenic T cells and NY-ESO-1 TCR/sr39TK transgenic stem cells | | Immune response against cancer expressing NY-ESO-1 |
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| NCT03841110 | I | Advanced solid tumors (inc expansion) | FT500 as Monotherapy and in Combination With Immune Checkpoint Inhibitors in Subjects With Advanced Solid Tumors (Phase 1) | View Drugs | California, Minnesota, Texas |
| Atezolizumab | Tecentriq, Anti-PD-L1 Monoclonal Antibody MPDL3280A, MPDL3280A, RG7446 | Blocks PD-L1 inhibition of T cells | | Cyclophosphamide | Sendoxan, Procytox, Ledoxina, Genoxal, Fosfaseron, Enduxan, Endoxana, Endoxan, Cytophosphan, Cyclostine, Cyclostin, CYCLO-cell, Cycloblastine, Cycloblastin, Cicloxal, Carloxan, Neosar, Cytoxan, Clafen, Zytoxan, Syklofosfamid, Mitoxan, Cytophosphane, Cyclophosphanum, Cyclophosphan, Cyclophosphamidum, Cyclophosphamid monohydrate, Cyclophospham, CPM, CP monohydrate, Claphene, Ciclofosfamide, Ciclofosfamida | DNA damaging agent | | Fludarabine | Fludara Oral, 2-F-ara-AMP, Beneflur | DNA synthesis inhibitor | | FT500 | | Anti-tumor immune response | | Nivolumab | BMS-936558, ONO-4538, MDX-1106, Anti-PD-1 human mab MDX-1106, Opdivo | Blocks PD-L1/2 inhibition of T cells | | Pembrolizumab | Keytruda, Lambrolizumab, SCH 900475, MK3475, MK-3475 | Blocks PD-L1/2 inhibition of T cells |
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| NCT03849469 | I | Advanced solid tumors (inc expansion) | A Phase 1 Multiple-Dose Study to Evaluate the Safety and Tolerability of XmAb®22841 Monotherapy and in Combination With Pembrolizumab in Subjects With Selected Advanced Solid Tumors (DUET-4) | View Drugs | Georgia, Michigan, Texas, Utah |
| Pembrolizumab | Keytruda, Lambrolizumab, SCH 900475, MK3475, MK-3475 | Blocks PD-L1/2 inhibition of T cells | | XmAb22841 | anti-CTLA-4/LAG-3 bispecific antibody XmAb22841 | Blocks LAG-3 and CTLA-4 inhibition of T cells |
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| NCT03861793 | I | Advanced solid tumors (inc expansion) | A Phase 1 Study of ALKS 4230 Administered Subcutaneously as Monotherapy and in Combination With Pembrolizumab in Subjects With Advanced Solid Tumors (ARTISTRY-2) | View Drugs | Georgia, North Carolina |
| ALKS 4230 | | IL-2 receptor agonist | | Pembrolizumab | Keytruda, Lambrolizumab, SCH 900475, MK3475, MK-3475 | Blocks PD-L1/2 inhibition of T cells |
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| NCT03556228 | I | Advanced solid tumors (inc expansion) | An Open-Label, Multiple-Dose, Dose-Escalation Study to Investigate the Safety, Pharmacokinetics, and Pharmacodynamics of VMD-928 in Subjects With Solid Tumors or Lymphoma | View Drugs | California |
| VMD-928 | TrkA inhibitor VMD-928 | TRK kinase inhibitor |
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| NCT03831295 | I | Advanced solid tumors - intratumoral injection | Intratumoral Injection of SD-101, an Immunostimulatory CpG Oligonucleotide, in Combination With BMS- 986178, an OX40 Agonist Antibody, in Advanced Solid Malignancies [CA012-014] | View Drugs | California |
| BMS-986178 | anti-OX40 antibody BMS 986178 | Stimulates OX40 to increase T cell activation and immune response | | SD-101 | TLR9 agonist SD-101, ISS-ODN SD-101 | TLR9 agonist and immune cell activator |
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| NCT03821935 | I | Advanced solid tumors | A Phase 1 First-in Human, Multi-Center, Open Label Dose-Escalation Study to Determine the Safety, Tolerability, Pharmacokinetics and RP2D of ABBV-151 as a Single Agent and in Combination With ABBV-181 in Subjects With Locally Advanced or Metastatic Solid Tumors | View Drugs | Connecticut, Indiana, North Carolina, Texas |
| ABBV-151 | ARGX-115 | binds GARP in complex with inactive TGF-beta preventing release of active TGF-beta | | ABBV-181 | anti-PD1 monoclonal antibody ABBV-181 | Blocks PD-L1 inhibition of T cells |
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| NCT03875287 | I | Advanced solid tumors | A Phase I Dose-Escalation Study of E7727, an Oral Cytidine Deaminase Inhibitor (CDAi) With Oral Decitabine in Subjects With Solid Tumors | View Drugs | Maryland |
| ASTX727 | CDA inhibitor E7727/decitabine combination agent ASTX727 | DNA methylation inhibitor |
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| NCT03156114 | I | Advanced solid tumors with high MSI or high TMB and prior checkpoint inhibitor treatment (in expansion) | An Open Label, Phase I Dose-finding Study of BI 754111 in Combination With BI 754091 in Patients With Advanced Solid Cancers Followed by Expansion Cohorts at the Selected Dose of the Combination in Patients With Non-small Cell Lung Cancer and Other Solid Tumors | View Drugs | Florida, New Jersey, Oklahoma, Tennessee, Wisconsin |
| BI 754091 | anti-PD-1 monoclonal antibody BI 754091 | Blocks PD-L1/2 inhibition of T cells | | BI 754111 | | Blocks LAG-3 inhibition of T cells |
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| NCT02990481 | I | Advanced solid tumors (in expansion) | A Phase 1, Multicenter, Open-label, Dose-Escalation, Safety, Pharmacokinetic and Pharmacodynamic Study of TRK-950 Given Intravenously in Patients With Advanced Solid Tumors | View Drugs | Arizona |
| TRK-950 | monoclonal antibody TRK-950 | Undisclosed mechanism |
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| NCT03132922 | I | Advanced MAGE-A4+, HLA-A1+ solid tumors | Phase 1 Dose Escalation, Multi-tumor Study to Assess the Safety, Tolerability and Antitumor Activity of Genetically Engineered MAGE-A4ᶜ¹º³²T in HLA-A2+ Subjects With MAGE-A4 Positive Tumors | View Drugs | Florida, Missouri, New York, North Carolina, Pennsylvania, Tennessee, Texas |
| Cyclophosphamide | Sendoxan, Procytox, Ledoxina, Genoxal, Fosfaseron, Enduxan, Endoxana, Endoxan, Cytophosphan, Cyclostine, Cyclostin, CYCLO-cell, Cycloblastine, Cycloblastin, Cicloxal, Carloxan, Neosar, Cytoxan, Clafen, Zytoxan, Syklofosfamid, Mitoxan, Cytophosphane, Cyclophosphanum, Cyclophosphan, Cyclophosphamidum, Cyclophosphamid monohydrate, Cyclophospham, CPM, CP monohydrate, Claphene, Ciclofosfamide, Ciclofosfamida | DNA damaging agent | | Fludarabine | Fludara Oral, 2-F-ara-AMP, Beneflur | DNA synthesis inhibitor | | MAGE-A4ᶜ¹º³²T | MAGE-A4 SPEAR, engineered T-cells targeting melanoma-associated antigen-A4 (MAGE-A4) | Immune response against cancer expressing MAGE-A4 |
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| NCT03748186 | I | Recurrent ovarian cancer (inc expansion) | A Phase 1 Open-Label, Safety, Pharmacokinetic and Preliminary Efficacy Study of STRO-002, an Anti-Folate Receptor Alpha (FolRα) Antibody Drug Conjugate (ADC) in Advanced Epithelial Ovarian Cancer and Endometrial Cancers | View Drugs | Colorado, Florida, Illinois, Nevada, North Carolina, Pennsylvania, Tennessee, Wisconsin |
| STRO-002 | | ADC: anti-FOLR1 + microtubule destabilizer (SC209) |
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| NCT03538028 | I | Advanced solid tumors (inc expansion) | A Phase 1 Open-Label, Dose-Escalation, Safety and Tolerability Study of INCAGN02385 in Participants With Select Advanced Malignancies | View Drugs | California, New Jersey, North Carolina, Tennessee |
| INCAGN02385 | | Blocks LAG-3 inhibition of T cells |
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| NCT03134638 | I | Advanced solid tumors (in ovarian expansion) | A Phase 1 Study of SY-1365, a Selective CDK7 Inhibitor, in Adult Patients With Advanced Solid Tumors | View Drugs | Alabama, Arizona, California, Illinois, Massachusetts, New York, Oklahoma, Oregon, Rhode Island, Tennessee, Texas |
| Carboplatin | Paraplatin, Novoplatinum | DNA damaging agent | | SY-1365 | CDK7 inhibitor SY-1365, SY 1365 | CDK7 inihibitor |
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| NCT03517956 | I | Advanced solid tumors with FGFR over-expression | A Multicenter Phase 1 Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Maximum Tolerated Dose (MTD) and/or Recommended Phase 2 Dose (RP2D) of the Combination of Rogaratinib and Copanlisib in Patients With FGFR-positive, Locally Advanced or Metastatic Solid Tumors | View Drugs | California, Illinois, Maryland, Massachusetts, Michigan, Nevada, New York, South Carolina, Texas |
| Copanlisib | BAY 80-6946, MEK inhibitor BAY 80-6946, PI3K inhibitor BAY 80-6946 | pan-PI3K inhibitor | | Rogaratinib | pan-FGFR tyrosine kinase inhibitor BAY1163877, BAY1163877 | pan-FGFR kinase inhibitor |
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| NCT03255070 | I | Advanced HER+ solid tumors | A Phase 1, Multicenter, Open-label, Multiple Dose-escalation Study of ARX788, Intravenously Administered as a Single Agent in Subjects With Advanced Cancers With HER2 Expression | View Drugs | Missouri |
| ARX788 | anti-HER2 antibody-drug conjugate ARX788, ADC ARX788 | ADC: anti-HER2 + microtubule destabilizer (MMAF) |
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| NCT03330561 | I | Advanced HER2+ solid tumors (inc expansion) | A Phase 1, Open-Label, Dose Escalation Study of PRS-343 in Patients With HER2-Positive Advanced or Metastatic Solid Tumors | View Drugs | Arizona, California, District of Columbia, Maryland, New York, Pennsylvania, Tennessee, Texas |
| PRS-343 | anti-HER2 monoclonal antibody/anti-CD137 anticalin bispecific fusion protein PRS-343 | Immune response against cancer expressing HER2 |
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| NCT03585764 | I | Recurrent or persistent FRalpha+ high grade serous ovarian cancer | Phase I Clinical Trial of Adoptive Transfer of Autologous Folate Receptor - Alpha Redirected T Cells for Recurrent High Grade Serous Ovarian, Fallopian Tube, or Primary Peritoneal Cancer | View Drugs | Pennsylvania |
| Cyclophosphamide | Sendoxan, Procytox, Ledoxina, Genoxal, Fosfaseron, Enduxan, Endoxana, Endoxan, Cytophosphan, Cyclostine, Cyclostin, CYCLO-cell, Cycloblastine, Cycloblastin, Cicloxal, Carloxan, Neosar, Cytoxan, Clafen, Zytoxan, Syklofosfamid, Mitoxan, Cytophosphane, Cyclophosphanum, Cyclophosphan, Cyclophosphamidum, Cyclophosphamid monohydrate, Cyclophospham, CPM, CP monohydrate, Claphene, Ciclofosfamide, Ciclofosfamida | DNA damaging agent | | Fludarabine | Fludara Oral, 2-F-ara-AMP, Beneflur | DNA synthesis inhibitor | | MOv19-BBz CAR T | | Immune response against cancer expressing folate receptor |
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| NCT03486301 | I | Advanced solid tumors (inc expansion) | Phase 1 Open-Label Dose Escalation Study of BDB001 as a Single Agent and in Combination With Pembrolizumab in Subjects With Advanced Solid Tumors | View Drugs | Florida, Tennessee, Texas |
| BDB001 | | TLR agonist and immune cell stimulator | | Pembrolizumab | Keytruda, Lambrolizumab, SCH 900475, MK3475, MK-3475 | Blocks PD-L1/2 inhibition of T cells |
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| NCT03665129 | I | Advanced solid tumors | A Phase I Study of the Anti-C5aR, IPH5401, in Combination With the Anti-PD-L1, Durvalumab, in Patients With Selected Advanced Solid Tumors | View Drugs | Tennessee, Texas |
| Durvalumab | Anti-B7H1 Monoclonal Antibody MEDI4736, MEDI4736, Imfinzi | Blocks PD-L1 inhibition of T cells | | IPH5401 | | Blocks C5aR mediated inhibition of T and NK cells |
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| NCT03691376 | I | Recurrent or refractory NY-ESO-1+ ovarian cancer | A Phase I, Open Label Study Evaluating the Safety and Efficacy of Adoptive Transfer of Autologous NY-ESO-1 CD8-TCR Engineered T Cells and NY-ESO-1 CD4-TCR Engineered Hematopoietic Stem Cells (HSC) After a Myeloablative Conditioning Regimen, With Administration of IL-2 in Patients With Recurrent or Treatment Refractory Ovarian, Fallopian Tube or Primary Peritoneal Cancer | View Drugs | New York |
| Aldesleukin | | IL-2 receptor agonist | | Melphalan | Sarcolysin, Alkeran, Alkerana, Melfalan, Phenylalanine mustard | DNA damaging agent | | NY-ESO-1 CD4-TCR Engineered Hematopoietic Stem Cells (HSC) | | Immune response against cancer expressing NY-ESO-1 | | NY-ESO-1 CD8-TCR Engineered T Cells | | Immune response against cancer expressing NY-ESO-1 |
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| NCT03502733 | I | Advanced solid tumors | Phase Ib Combination Study of Copanlisib and Nivolumab in Advanced Solid Tumors and Lymphomas | View Drugs | Maryland, Texas |
| Copanlisib | BAY 80-6946, MEK inhibitor BAY 80-6946, PI3K inhibitor BAY 80-6946 | pan-PI3K inhibitor | | Nivolumab | BMS-936558, ONO-4538, MDX-1106, Anti-PD-1 human mab MDX-1106, Opdivo | Blocks PD-L1/2 inhibition of T cells |
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| NCT03099109 | I | Advanced solid tumors (inc expansion) | A Phase 1a/1b Study of LY3321367, an Anti-TIM-3 Antibody, Administered Alone or in Combination With LY3300054, an Anti-PD-L1 Antibody, in Advanced Relapsed/Refractory Solid Tumors | View Drugs | Arizona, Massachusetts, Michigan, New York, Oklahoma, Pennsylvania, Tennessee, Texas |
| LY3300054 | | Blocks PD-L1 inhibition of T cells | | LY3321367 | anti-TIM3 monoclonal antibody LY3321367 | Blocks TIM-3 inhibition of T cells |
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| NCT02516813 | I | Ovarian cancer with an indication for palliative radiation therapy | An Open Label, Phase Ia/Ib Trial of the DNA-PK Inhibitor MSC2490484A in Combination With Radiotherapy in Patients With Advanced Solid Tumors | View Drugs | Florida, New York, Pennsylvania |
| Cisplatin | CACP, cis-DDP, cis-platinum, CDDP, Platinol, Abiplatin, Blastolem, Briplatin, Cisplatyl, Citoplatino, Citosin, Lederplatin, Metaplatin, Neoplatin, Placis, Platamine, Platiblastin, Platiblastin-S, Platinex, Platinol, Platiran, Platistin, Platosin | DNA damaging agent | | M3814 | DNA-PK inhibitor MSC2490484A, Nedisertib | DNA-PK inhibitor |
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| NCT03739931 | I | Advanced solid tumors (inc expansion) - intratumoral injection | A Phase 1, Open-Label, Multicenter, Dose Escalation Study of mRNA-2752, a Lipid Nanoparticle Encapsulating mRNAs Encoding Human OX40L, IL-23, and IL-36γ, for Intratumoral Injection Alone and in Combination With Immune Checkpoint Blockade | View Drugs | Colorado, Connecticut, Florida, Michigan, Tennessee |
| Durvalumab | Anti-B7H1 Monoclonal Antibody MEDI4736, MEDI4736, Imfinzi | Blocks PD-L1 inhibition of T cells | | mRNA-2752 | lipid nanoparticle-encapsulated OX40L, IL23, IL36gamma mRNA-2752 | | | Tremelimumab | anti-CTLA4 human monoclonal antibody CP-675,206, CP-675, CP-675,206, CP-675206, Ticilimumab | Blocks CTLA-4 inhibition of T cells |
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| NCT03139370 | I | Advanced MAGE-A3/A6+, HLA-DPB1*04:01+ (inc expansion) | A Phase 1 Study Evaluating the Safety and Efficacy of MAGE-A3/A6 T Cell Receptor Engineered T Cells (KITE-718) in HLA-DPB1*04:01 Positive Subjects With Advanced Cancers | View Drugs | California, Florida, Massachusetts, New York, Texas |
| Cyclophosphamide | Sendoxan, Procytox, Ledoxina, Genoxal, Fosfaseron, Enduxan, Endoxana, Endoxan, Cytophosphan, Cyclostine, Cyclostin, CYCLO-cell, Cycloblastine, Cycloblastin, Cicloxal, Carloxan, Neosar, Cytoxan, Clafen, Zytoxan, Syklofosfamid, Mitoxan, Cytophosphane, Cyclophosphanum, Cyclophosphan, Cyclophosphamidum, Cyclophosphamid monohydrate, Cyclophospham, CPM, CP monohydrate, Claphene, Ciclofosfamide, Ciclofosfamida | DNA damaging agent | | Fludarabine | Fludara Oral, 2-F-ara-AMP, Beneflur | DNA synthesis inhibitor | | KITE-718 | MAGEA3/A6-targeted TCR-transduced T cells KITE-718, autologous MAGE-A3/A6-specific TCR gene-engineered lymphocytes KITE-718 | immune response against cancer expressing MAGE-A3/A6 |
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| NCT03724890 | I | Advanced solid tumors | A Multicenter, Open-Label, Dose Escalation Phase I Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of the DNA-PK Inhibitor M3814 in Combination With Avelumab With and Without Palliative Radiotherapy in Participants With Selected Advanced Solid Tumors | View Drugs | California, Florida, Illinois, New York, Ohio, Oklahoma, South Carolina, Tennessee |
| Avelumab | Anti programmed death ligand 1 monoclonal antibody, Anti-PD-L1, MSB0010718C, Bavencio | Blocks PD-L1 inhibition of T cells | | M3814 | DNA-PK inhibitor MSC2490484A, Nedisertib | DNA-PK inhibitor | | Radiation Therapy | Radiotherapy, Irradiation | |
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| NCT03725436 | I | Advanced solid tumors that are TP53 WT | A Phase 1b Study of ALRN-6924 in Combination With Paclitaxel in Wild-Type TP53 Advanced or Metastatic Solid Tumors Including Estrogen-Receptor Positive Breast Cancer | View Drugs | Texas |
| ALRN-6924 | MDM2/MDMX inhibitor ALRN-6924 | MDM2 and MDMX inhibitor | | Paclitaxel | Anzatax, Asotax, Bristaxol, Praxel, Taxol, Taxol Konzentrat, TXL | Microtubule stabilizer/mitotic inhibitor |
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| NCT03719326 | I | Advanced ovarian cancer (inc expansion) | A Phase 1/1b Study to Evaluate the Safety and Tolerability of Immunotherapy Combinations in Participants With Breast and Gynecologic Malignancies | View Drugs | Arizona, California, Colorado, Florida, Maryland, Minnesota, Nevada, New York, North Carolina, Oregon, Texas, Virginia, Washington |
| AB928 | AB928, a dual antagonist of the A2aR and A2bR adenosine receptors | Blocks adenosine A2A/B receptors inhibition of T cells | | IPI-549 | PI3K-gamma inhibitor IPI-549 | PI3K gamma inhibitor | | Liposomal doxorubicin | Doxil, Dox-SL, Evacet, LipoDox, liposomal doxorubicin, Pegylated Liposomal Doxorubicin Hydrochloride | Topoisomerase II inhibitor |
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| NCT04087018 | I | Advanced solid tumors with high TMB or positive Strata Immune Signature | A Phase 1b Study to Evaluate the Safety and Clinical Activity of AB122 in Biomarker-Selected Participants With Advanced Solid Tumors | View Drugs | Wisconsin |
| AB122 | anti-PD-1 monoclonal antibody AB122 | Blocks PD-L1 inhibition of T cells |
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| NCT04088786 | I | Patients with peritoneal disease who are candidates for grossly complete cytoreduction surgery | Phase I Trial of Cytoreductive Surgery and Heated Intraperitoneal Chemotherapy With Nanoliposomal Irinotecan in Patients With Peritoneal Surface Malignancies | View Drugs | California, Kentucky, New York |
| Liposomal irinotecan | Onivyde, MM-398, liposome-encapsulated irinotecan hydrochloride PEP02, nal-IRI, nanoliposomal irinotecan | Topoisomerase I inhibitor |
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| NCT04092270 | I | Recurrent ovarian cancer (inc expansion) | A Phase I/Ib Dose Escalation Study of Pegylated Liposomal Doxorubicin (PLD) With M3814 in Ovarian Cancer With Planned Expansions in High Grade Serous (HGSOC) and Low Grade Serous Ovarian Cancer (LGSOC) | View Drugs | Contact NCI |
| Liposomal doxorubicin | Doxil, Dox-SL, Evacet, LipoDox, liposomal doxorubicin, Pegylated Liposomal Doxorubicin Hydrochloride | Topoisomerase II inhibitor | | M3814 | DNA-PK inhibitor MSC2490484A, Nedisertib | DNA-PK inhibitor |
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| NCT04095273 | I | Advanced solid tumors DNA Damage Repair pathway alterations (with ovarian expansion) | A Multicenter, Non-randomized, Open-label Phase 1b Study to Determine the Maximum Tolerated and Recommended Phase 2 Dose of the ATR Inhibitor BAY1895344 in Combination With Pembrolizumab and to Characterize Its Safety, Tolerability, Pharmacokinetics and Preliminary Anti-tumor Activity in Patients With Advanced Solid Tumors | View Drugs | California, Maryland, Ohio, Texas |
| BAY1895344 | ATR kinase inhibitor BAY1895344 | ATR kinase inhibitor | | Pembrolizumab | Keytruda, Lambrolizumab, SCH 900475, MK3475, MK-3475 | Blocks PD-L1/2 inhibition of T cells |
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| NCT04053673 | I | Advanced solid tumors (inc expansion) | A Phase 1, First-in-human Study of the Safety, Single- and Multiple-Dose Pharmacokinetics, and Preliminary Activity of Escalating Doses of RBN-2397, an Oral PARP7 Inhibitor, in Patients With Solid Tumors | View Drugs | Colorado, Florida, Tennessee |
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| NCT04034238 | I | Advanced mesothelin+ solid tumors | A Phase I Study of Mesothelin-Targeted Immunotoxin LMB-100 in Combination With Tofacitinib in Persons With Previously Treated Pancreatic Adenocarcinoma, Cholangiocarcinoma and Other Mesothelin Expressing Solid Tumors | View Drugs | Maryland |
| LMB-100 | anti-mesothelin recombinant cytolytic fusion protein RO6927005, anti-mesothelin cytolytic fusion protein LMB-100 | ADC: anti-mesothelin + Pseudomonas exotoxin (PE) | | Tofacitinib | Tasocitinib, CP-690550 | JAK kinase inhibitor |
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| NCT04007744 | I | Advanced solid tumors with high MSI | A Phase 1 Trial of Sonidegib and Pembrolizumab in Advanced Solid Tumors | View Drugs | Arizona, Florida, Minnesota |
| Pembrolizumab | Keytruda, Lambrolizumab, SCH 900475, MK3475, MK-3475 | Blocks PD-L1/2 inhibition of T cells | | Sonidegib | LDE225, Smoothened Antagonist LDE225, Erismodegib, Odomzo | Smoothened antagonist |
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| NCT03416335 | I | Advanced solid tumors | A First-in-Human Phase 1/2 Trial to Determine the Safety and the Pharmacokinetic Profile of DSP-0509, a Synthetic Toll-Like Receptor 7 (TLR-7) Agonist, Administered as Monotherapy and in Combination With Pembrolizumab in Adult Patients With Advanced Solid Tumors | View Drugs | Indiana, North Carolina, Pennsylvania, Tennessee, Texas |
| DSP-0509 | toll-like receptor 7 agonist DSP-0509 | TLR7 agonist and immune cell activator | | Pembrolizumab | Keytruda, Lambrolizumab, SCH 900475, MK3475, MK-3475 | Blocks PD-L1/2 inhibition of T cells |
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| NCT03968406 | I | Recurrent ovarian cancer (amenable to radiation therapy) - without ascites | Phase I Study of Talazoparib in Combination With Radiation Therapy for Locally Recurrent Gynecologic Cancers | View Drugs | Texas |
| Radiation Therapy | Radiotherapy, Irradiation | | | Talazoparib | Talazoparib Tosylate, BMN-673, MDV3800 | PARP inhibitor |
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| NCT03970382 | I | Advanced solid tumors (inc expansion) | A Phase 1a/1b, Open-label First-in-human Study of the Safety, Tolerability and Feasibility of Gene-edited Autologous NeoTCR-T Cells (NeoTCR-P1) Administered as a Single Agent or in Combination With Anti-PD-1 to Patients With Locally Advanced or Metastatic Solid Tumors | View Drugs | California |
| NeoTCR-P1 | gene-edited autologous neoantigen-targeted NeoTCR-P1 T cells | Anti-tumor immune response | | Nivolumab | BMS-936558, ONO-4538, MDX-1106, Anti-PD-1 human mab MDX-1106, Opdivo | Blocks PD-L1/2 inhibition of T cells |
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| NCT03219268 | I | Advanced solid tumors, including HER2+ cohort (inc expansion) | A Phase 1, First-in-Human, Open-Label, Dose Escalation Study of MGD013, A Bispecific DART® Protein Binding PD-1 and LAG-3 in Patients With Unresectable or Metastatic Neoplasms | View Drugs | Arizona, California, Florida, Illinois, Maryland, Massachusetts, North Carolina, Ohio, Oklahoma, Pennsylvania, Tennessee, Texas |
| Margetuximab | anti-HER2/c-erbB2 monoclonal antibody, anti-HER2 mAb MGAH22 | HER2 antagonist | | MGD013 | anti-PD-1/anti-LAG-3 DART protein MGD013, dual-affinity retargeting protein MGD013 | Blocks LAG-3 and PD-1 inhibition of T cells |
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| NCT03363893 | I | Advanced solid tumors (inc expansion) | A Modular, Multipart, Multiarm, Open-label, Phase I/II Study to Evaluate the Safety and Tolerability of CT7001 Alone and in Combination With Anti-cancer Treatments in Patients With Advanced Malignancies | View Drugs | New York |
| CT7001 | CDK7 inhibitor CT7001 | CDK7 inihibitor |
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