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III

Recurrent or progressive high grade serous or endometrioid ovarian cancer with BRCA1/2 mutations (>1 prior therapy)

ARIEL4 (Assessment of Rucaparib In Ovarian CancEr TriaL): A Phase 3 Multicenter, Randomized Study of Rucaparib Versus Chemotherapy in Patients With Relapsed, BRCA Mutant, High Grade Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

California, Colorado, Georgia, Maine, Ohio, Texas

Drug(s) in Trial	Other Drug Names	Main Known Action
Rucaparib	AG-014699, PF 01367338, CO-338, Rubraca	PARP inhibitor

IIa

Advanced solid tumors with ALK mutations or high TMB

My Pathway: An Open-Label Phase IIa Study Evaluating Trastuzumab/Pertuzumab, Erlotinib, Vemurafenib/Cobimetinib, Vismodegib, Alectinib, and Atezolizumab in Patients Who Have Advanced Solid Tumors With Mutations or Gene Expression Abnormalities Predictive of Response to One of These Agents

Arizona, Arkansas, California, Colorado, Florida, Georgia, Illinois, Maryland, Minnesota, Missouri, New York, North Carolina, North Dakota, Ohio, Oklahoma, Pennsylvania, South Dakota, Tennessee, Texas, Washington, Wisconsin

Drug(s) in Trial	Other Drug Names	Main Known Action
Alectinib	ALK inhibitor CH5424802, Alecensa, anaplastic lymphoma kinase inhibitor CH5424802, AF802	ALK kinase inhibitor
Atezolizumab	RG7446, MPDL3280A, Anti-PD-L1 Monoclonal Antibody MPDL3280A, Tecentriq	Blocks PD-L1 inhibition of T cells

IIa

Recurrent ovarian cancer

A Phase 1/2a Evaluation of the Safety and Efficacy of Adding AL3818, a Dual Receptor Tyrosine Kinase Inhibitor, to Standard Platinum-Based Chemotherapy, in Subjects With Recurrent or Metastatic Endometrial, Ovarian, Fallopian, Primary Peritoneal or Cervical Carcinoma (AL3818-US-002)

California, Florida, Louisiana, Texas

Drug(s) in Trial	Other Drug Names	Main Known Action
Anlotinib	AL3818	VEGFR2/3 kinase inhibitor
Carboplatin	Paraplatin, Novoplatinum	DNA damaging agent
Paclitaxel	Anzatax, Asotax, Bristaxol, Praxel, Taxol, Taxol Konzentrat, TXL	Microtubule stabilizer/mitotic inhibitor

IIa

Platinum resistant or refractory ovarian cancer with BRCA1/2-mutations

A Phase I/IIa Trial With BMS-986158, a Small Molecule Inhibitor of the Bromodomain and Extra-Terminal (BET) Proteins, as Monotherapy or in Combination With Nivolumab in Subjects With Selected Advanced Solid Tumors or Hematologic Malignancies

California, Colorado, Oregon, South Carolina

Drug(s) in Trial	Other Drug Names	Main Known Action
BMS-986158	BET inhibitor BMS-986158	BET inhibitor
Nivolumab	BMS-936558, ONO-4538, MDX-1106, Anti-PD-1 human mab MDX-1106, Opdivo	Blocks PD-L1/2 inhibition of T cells

IIa

Advanced solid tumors (in expansion)

A Phase 1/2a Study of BMS-986205 Administered in Combination With Nivolumab (Anti-PD-1 Monoclonal Antibody) and in Combination With Both Nivolumab and Ipilimumab (Anti-CTLA-4 Monoclonal Antibody) in Advanced Malignant Tumors

Arizona, California, Florida, Georgia, Illinois, Maryland, Michigan, Missouri, New Jersey, New York, Ohio, Pennsylvania, Tennessee

Drug(s) in Trial	Other Drug Names	Main Known Action
BMS-986205		Inhibits IDO to stimulate immune response
Ipilimumab	Anti-Cytotoxic T-Lymphocyte-Associated Antigen-4 Monoclonal Antibody, MDX-010, Yervoy	Blocks CTLA-4 inhibition of T cells
Nivolumab	BMS-936558, ONO-4538, MDX-1106, Anti-PD-1 human mab MDX-1106, Opdivo	Blocks PD-L1/2 inhibition of T cells

II/III

Platinum resistant or refractory high grade serous or endometrioid ovarian cancer or germline BRCA1/2-mutant ovarian cancer

A Randomized Phase II/III Study of the Combination of Cediranib and Olaparib Compared to Cediranib or Olaparib Alone, or Standard of Care Chemotherapy in Women With Recurrent Platinum-Resistant or -Refractory Ovarian, Fallopian Tube, or Primary Peritoneal Cancer (COCOS)

Alaska, Arkansas, California, Colorado, Connecticut, Delaware, District of Columbia, Florida, Georgia, Hawaii, Idaho, Illinois, Indiana, Iowa, Kansas, Kentucky, Louisiana, Maine, Maryland, Massachusetts, Michigan, Minnesota, Mississippi, Missouri, Montana, Nebraska, Nevada, New Hampshire, New Jersey, New Mexico, New York, North Carolina, North Dakota, Ohio, Oklahoma, Oregon, Pennsylvania, Rhode Island, South Carolina, South Dakota, Tennessee, Texas, Utah, Vermont, Virginia, Washington, West Virginia, Wisconsin

Drug(s) in Trial	Other Drug Names	Main Known Action
Cediranib	Recentin, Cediranib maleate, AZD2171	VEGFR1-3 kinase inhibitor
Liposomal doxorubicin	Doxil, Dox-SL, Evacet, LipoDox, liposomal doxorubicin, Pegylated Liposomal Doxorubicin Hydrochloride	Topoisomerase II inhibitor
Olaparib	AZD2281, Lynparza	PARP inhibitor
Paclitaxel	Anzatax, Asotax, Bristaxol, Praxel, Taxol, Taxol Konzentrat, TXL	Microtubule stabilizer/mitotic inhibitor
Topotecan	Hycamptamine, Hycamtin, TOPO	Topoisomerase I inhibitor

II

Platinum resistant or refractory ovarian cancer ( > 2 prior platinum therapies)

Phase I/II Study of the Anti-Programmed Death Ligand-1 Antibody MEDI4736 in Combination With Olaparib and/or Cediranib for Advanced Solid Tumors and Advanced or Recurrent Ovarian, Triple Negative Breast, Lung, Prostate and Colorectal Cancers

Maryland

Drug(s) in Trial	Other Drug Names	Main Known Action
Cediranib	Recentin, Cediranib maleate, AZD2171	VEGFR1-3 kinase inhibitor
Durvalumab	Anti-B7H1 Monoclonal Antibody MEDI4736, MEDI4736, Imfinzi	Blocks PD-L1 inhibition of T cells
Olaparib	AZD2281, Lynparza	PARP inhibitor

II

Advanced Solid Tumors with FGFR1-4, PDGFRa, Kit, RET, FLT3, or Abl1 alterations

Phase II Study of Ponatinib for Advanced Cancers With Genomic Alterations in Fibroblastic Growth Factor Receptor (FGFR) and Other Genomic Targets (KIT, PDGFRá, RET FLT3, ABL1)

Ohio

Drug(s) in Trial	Other Drug Names	Main Known Action
Ponatinib	multitargeted tyrosine kinase inhibitor AP24534, Iclusig, AP24534	Multi-targeted kinase inhibitor

II

Advanced solid tumors with KRAS or NRAS mutations (in expansion)

An Open Label, Two-Part, Phase Ib/II Study to Investigate the Safety, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of the MEK Inhibitor Trametinib and the BCL2-Family Inhibitor Navitoclax (ABT-263) in Combination in Subjects With KRAS or NRAS Mutation-Positive Advanced Solid Tumors

Massachusetts

Drug(s) in Trial	Other Drug Names	Main Known Action
Navitoclax	Bcl-2 Family Protein Inhibitor ABT-263, A-855071.0, ABT-263	Bcl-2, Bcl-XL, and Bcl-w inhibitor
Trametinib	Mekinist, MEK Inhibitor GSK1120212, JTP-74057, GSK1120212, TMT212	MEK1/2 inhibitor

II

Advanced solid tumors with CCND1/2 AMP, CDK4/6 MUT, or other G1/S alterations

Phase II Trial of the Cyclin-Dependent Kinase Inhibitor PD 0332991 in Patients With Cancer

Pennsylvania

Drug(s) in Trial	Other Drug Names	Main Known Action
Palbociclib	PD-0332991, PD0332991, Ibrance	CDK4/6 inhibitor

II

Advanced solid tumors with activating HER2 mutations

An Open-label, Phase 2 Study of Neratinib in Patients With Solid Tumors With Somatic Human Epidermal Growth Factor Receptor (EGFR, HER2, HER3) Mutations or EGFR Gene Amplification.

Arizona, California, Florida, Illinois, Louisiana, Massachusetts, Minnesota, Missouri, New York, Ohio, Pennsylvania, Tennessee, Texas, Wisconsin

Drug(s) in Trial	Other Drug Names	Main Known Action
Neratinib	HKI-272, PD272	EGFR, HER2, HER4 kinase inhibitor

II

Recurrent high grade serous or endometrioid or germline BRCA1/2-mutated ovarian cancer

A Phase II Single Arm Pilot Study of the Chk1/2 Inhibitor (LY2606368) In BRCA1/2 Mutation Associated Breast or Ovarian Cancer, Triple Negative Breast Cancer, and High Grade Serous Ovarian Cancer

Maryland

Drug(s) in Trial	Other Drug Names	Main Known Action
Prexasertib	checkpoint kinase 1 inhibitor LY2606368, LY2606368	Chk1/2 inhibitor

II

Platinum resistant or refractory ovarian cancer

Avatar-Directed Chemotherapy in Platinum-Resistant Ovarian, Primary Peritoneal and Fallopian Tube Cancers

Arizona, Florida, Minnesota

Drug(s) in Trial	Other Drug Names	Main Known Action
Gemcitabine	Gemzar	Ribonucleotide reductase and DNA synthesis inhibitor
Liposomal doxorubicin	Doxil, Dox-SL, Evacet, LipoDox, liposomal doxorubicin, Pegylated Liposomal Doxorubicin Hydrochloride	Topoisomerase II inhibitor
Paclitaxel	Anzatax, Asotax, Bristaxol, Praxel, Taxol, Taxol Konzentrat, TXL	Microtubule stabilizer/mitotic inhibitor
Topotecan	Hycamptamine, Hycamtin, TOPO	Topoisomerase I inhibitor

II

Platinum resistant, refractory, partially sensitive or persistent ovarian cancer (1 prior platinum-taxane)

An Open Label Dose Escalation/Expansion Study of Tremelimumab Alone or Combined With Olaparib for Recurrent or Persistent EOC (Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Carcinoma)

Maryland

Drug(s) in Trial	Other Drug Names	Main Known Action
Olaparib	AZD2281, Lynparza	PARP inhibitor
Tremelimumab	anti-CTLA4 human monoclonal antibody CP-675,206, CP-675, CP-675,206, CP-675206, Ticilimumab	Blocks CTLA-4 inhibition of T cells

II

Advanced solid tumors with NTRK1/2/3, ROS1, or ALK rearrangements

An Open-Label, Multicenter, Global Phase 2 Basket Study of Entrectinib for the Treatment of Patients With Locally Advanced or Metastatic Solid Tumors That Harbor NTRK1/2/3, ROS1, or ALK Gene Rearrangements

Arizona, California, Colorado, Connecticut, District of Columbia, Florida, Georgia, Hawaii, Illinois, Maryland, Massachusetts, Michigan, Minnesota, Missouri, Nevada, New Hampshire, New York, North Carolina, Ohio, Oklahoma, Oregon, Texas, Utah, Virginia, Washington, Wisconsin

Drug(s) in Trial	Other Drug Names	Main Known Action
Entrectinib	RXDX-101, TrkA/B/C/ROS1/ALK tyrosine kinase inhibitor RXDX-101	ALK, TRK, ROS1 kinase inhibitor

II

Advanced solid tumors with defined molecular alterations (VEGFR, Bcr-abl, SRC, LYN, LCK, ALK, ROS1, MET,CDKN2A/p16, CDK4, CDK6, CSF1R, PDGFR, mTOR, TSC, ERBB2, BRAFV600E, Bcr-abl, SRC, KIT, PDGFRB, RAF-1,BRAF, EPHA2, FYN, LCK, YES1, RET, BRCA1/BRCA2, ATM, POLD, POLE, highTMB)

Targeted Agent and Profiling Utilization Registry (TAPUR) Study

Alabama, Arizona, California, Florida, Georgia, Illinois, Michigan, Nebraska, North Carolina, North Dakota, Oklahoma, Oregon, Pennsylvania, South Dakota, Texas, Utah, Virginia, Washington

Drug(s) in Trial	Other Drug Names	Main Known Action
Axitinib	Inlyta, AG-013736	Multi-targeted RTK inhibitor
Bosutinib	Bosulif, SKI-606	Abl and src family kinase inhibitor
Cetuximab	Erbitux, Anti-EGFR Monoclonal Antibody, Chimeric MoAb C225	EGFR antagonist
Cobimetinib	Cotellic, GDC-0973, XL518	MEK1 inhibitor
Crizotinib	c-met/HGFR tyrosine kinase inhibitor PF-02341066, PF-02341066, Xalkori	c-Met and ALK kinase inhibitor
Dasatinib	BMS-354825, Sprycel	SRC and bcr-abl kinase inhibitor
Ipilimumab	Anti-Cytotoxic T-Lymphocyte-Associated Antigen-4 Monoclonal Antibody, MDX-010, Yervoy	Blocks CTLA-4 inhibition of T cells
Nivolumab	BMS-936558, ONO-4538, MDX-1106, Anti-PD-1 human mab MDX-1106, Opdivo	Blocks PD-L1/2 inhibition of T cells
Olaparib	AZD2281, Lynparza	PARP inhibitor
Palbociclib	PD-0332991, PD0332991, Ibrance	CDK4/6 inhibitor
Pembrolizumab	MK3475, SCH 900475, Lambrolizumab, Keytruda	Blocks PD-L1/2 inhibition of T cells
Pertuzumab	Perjeta, monoclonal antibody 2C4, rhuMAb2C4	HER2 dimerization inhibitor
Regorafanib	BAY73-4506, multikinase inhibitor BAY 73-4506, Stivarga	Multi-targeted RTK inhibitor
Sunitinib	Sunitinib malate, Sutent	VEGFR2, PDGFR-beta, c-Kit, and FLT3 kinase inhibit
Temsirolimus	CCI-779, Torisel	mTOR inhibitor
Trastuzumab	Herceptin, Anti-erbB2 Monoclonal Antibody, HER2 Monoclonal Antibody	HER2 antagonist
Vemurafenib	Zelboraf, PLX4032, RO5185426	BRAF kinase inhibitor

II

Advanced solid tumors with alterations in ALK, cKIT, EGFR, ERBB2 AMP, FGFR1-3, FGFR1-3 AMP, GNAQ, GNA11, MET, mTOR, NTRK1-3, PIK3CA, PTCH1, PTEN, ROS1, SMO, TSC1/2

Molecular Analysis for Therapy Choice (MATCH)

Alabama, Alaska, Arizona, Arkansas, California, Colorado, Connecticut, Delaware, District of Columbia, Florida, Georgia, Hawaii, Idaho, Illinois, Indiana, Iowa, Kansas, Kentucky, Louisiana, Maine, Maryland, Massachusetts, Michigan, Minnesota, Mississippi, Missouri, Montana, Nebraska, Nevada, New Hampshire, New Jersey, New Mexico, New York, North Carolina, North Dakota, Ohio, Oklahoma, Oregon, Pennsylvania, Rhode Island, South Carolina, South Dakota, Tennessee, Texas, Utah, Vermont, Virginia, Washington, West Virginia, Wisconsin, Wyoming

Drug(s) in Trial	Other Drug Names	Main Known Action
Afatinib	BIBW 2992 MA2, Gilotrif, Afatinib dimaleate	EGFR, HER2, HER4 kinase inhibitor
Copanlisib	BAY 80-6946, MEK inhibitor BAY 80-6946, PI3K inhibitor BAY 80-6946	pan-PI3K inhibitor
Crizotinib	c-met/HGFR tyrosine kinase inhibitor PF-02341066, PF-02341066, Xalkori	c-Met and ALK kinase inhibitor
Erdafitinib	pan-FGFR tyrosine kinase inhibitor JNJ-42756493	pan-FGFR kinase inhibitor
Larotrectinib	Trk inhibitor LOXO-101	Pan-Trk kinase inhibitor
Osimertinib	Tagrisso, AZD9291, EGFR inhibitor AZD9291, Mereletinib	EGFR kinase inhibitor
Pertuzumab	Perjeta, monoclonal antibody 2C4, rhuMAb2C4	HER2 dimerization inhibitor
Sapanisertib	TAK-228, MLN0128, TORC1/2 Inhibitor MLN0128, TORC1/2 Inhibitor INK128, INK128	TORC1/2 kinase inhibitor
Sunitinib	Sunitinib malate, Sutent	VEGFR2, PDGFR-beta, c-Kit, and FLT3 kinase inhibit
Trametinib	Mekinist, MEK Inhibitor GSK1120212, JTP-74057, GSK1120212, TMT212	MEK1/2 inhibitor
Trastuzumab	Herceptin, Anti-erbB2 Monoclonal Antibody, HER2 Monoclonal Antibody	HER2 antagonist
Vismodegib	Hedgehog antagonist GDC-0449, Erivedge, GDC-0449	Smoothened antagonist

II

Advanced solid tumors with high MSI

A Clinical Trial of Pembrolizumab (MK-3475) Evaluating Predictive Biomarkers in Subjects With Advanced Solid Tumors (KEYNOTE 158)

California, Colorado, Florida, Maryland, Massachusetts, Minnesota, New Jersey, New Mexico, Texas

Drug(s) in Trial	Other Drug Names	Main Known Action
Pembrolizumab	MK3475, SCH 900475, Lambrolizumab, Keytruda	Blocks PD-L1/2 inhibition of T cells

II

Advanced solid tumors with AKT, ARID1A, ATM, CDKN2A, CHEK2, IDH1/2, KRAS, MRE11A, PIK3CA, PTEN, TP53 and other HDR gene mutations

A Phase II Study of the PARP Inhibitor Olaparib (AZD2281) Alone and in Combination With AZD1775, AZD5363, or AZD6738 in Advanced Solid Tumors

Connecticut, Massachusetts, Ohio, Tennessee

Drug(s) in Trial	Other Drug Names	Main Known Action
Adavosertib	WEE1 inhibitor AZD1775, MK1775, AZD1775	WEE1 inhibitor
AZD6738		ATR kinase inhibitor
Capivasertib	Akt inhibitor AZD5363	pan-AKT inhibitor
Olaparib	AZD2281, Lynparza	PARP inhibitor

II

Recurrent ovarian cancer

A Phase 1b/2 Study of an Immunotherapeutic Vaccine, DPX-Survivac With Low Dose Cyclophosphamide and Epacadostat (INCB024360) in Patients With Recurrent Ovarian Cancer

California, Georgia, New York, Oregon, Pennsylvania, Texas

Drug(s) in Trial	Other Drug Names	Main Known Action
Cyclophosphamide	Ciclofosfamida, Ciclofosfamide, Claphene, CP monohydrate, CPM, Cyclophospham, Cyclophosphamid monohydrate, Cyclophosphamidum, Cyclophosphan, Cyclophosphanum, Cytophosphane, Mitoxan, Syklofosfamid, Zytoxan, Clafen, Cytoxan, Neosar, Carloxan, Cicloxal, Cycloblastin, Cycloblastine, CYCLO-cell, Cyclostin, Cyclostine, Cytophosphan, Endoxan, Endoxana, Enduxan, Fosfaseron, Genoxal, Ledoxina, Procytox, Sendoxan	DNA damaging agent
DPX-Survivac	survivin antigen vaccine DPX-Survivac	Immune response against cancer expressing survivin
Epacadostat	3-dioxygenase Inhibitor INCB024360, Indoleamine-2,3-dioxygenase Inhibitor INCB024360, INCB024360, IDO1 Inhibitor INCB024360	Inhibits IDO to stimulate immune response

II

Platinum resistant or refractory ovarian cancer (< 4 prior cytotoxic therapies)

A Phase Ib/II Clinical Study of BBI608 Administered With Paclitaxel in Adult Patients With Advanced Malignancies

Indiana

Drug(s) in Trial	Other Drug Names	Main Known Action
Napabucasin	cancer stemness inhibitor BBI608, BBI608	STAT3 and cancer stemness inhibitor
Paclitaxel	Anzatax, Asotax, Bristaxol, Praxel, Taxol, Taxol Konzentrat, TXL	Microtubule stabilizer/mitotic inhibitor

II

Advanced solid tumors (in ovarian expansion)

A Phase 1b/2 Open-Label Study To Evaluate Safety, Clinical Activity, Pharmacokinetics And Pharmacodynamics Of Avelumab (MSB0010718C) In Combination With Other Cancer Immunotherapies In Patients With Advanced Malignancies

California, District of Columbia, Florida, Iowa, Michigan, New York, North Carolina, Pennsylvania, Rhode Island, South Dakota, Tennessee, Texas, Washington

Drug(s) in Trial	Other Drug Names	Main Known Action
Avelumab	Anti programmed death ligand 1 monoclonal antibody, Anti-PD-L1, MSB0010718C, Bavencio	Blocks PD-L1 inhibition of T cells
PD-0360324	anti–M-CSF mAb PD-0360324, anti-CSF1 monoclonal antibody PD-0360324	CSF1R antagonist and tumor-associated macrophage inhibitor
PF-04518600	anti-OX40 antibody PF-04518600	Stimulates OX40 to increase T cell activation and immune response

II

Advanced solid tumors

An Open Label Phase 2 Multi-cohort Trial of Nivolumab in Advanced or Metastatic Malignancies

Arizona, California, Colorado, Florida, Illinois, Indiana, Maryland, Minnesota, Missouri, Nebraska, Nevada, New Jersey, New York, Oregon, South Carolina, Tennessee, Texas, Virginia

Drug(s) in Trial	Other Drug Names	Main Known Action
Nivolumab	BMS-936558, ONO-4538, MDX-1106, Anti-PD-1 human mab MDX-1106, Opdivo	Blocks PD-L1/2 inhibition of T cells

II

Advanced solid tumors and granulosa cell ovarian cancer (in expansion)

A Phase I/II Trial of TRC102 (Methoxyamine HCl) in Combination With Temozolomide in Patients With Relapsed Solid Tumors and Lymphomas

Maryland

Drug(s) in Trial	Other Drug Names	Main Known Action
methoxyamine	TRC102	Base excision repair inhibitor
Temozolomide	Temodal, Temodar, Methazolastone	DNA damaging agent

II

Advanced solid tumors with MYC or CCNE1 amplification, Rb loss, or FBXW7, BRCA1, BRCA2, PALB2, RAD51C, RAD51D, ATR, ATM, CHEK2, Fanconi anemia pathway mutations

A Phase II Study of the CHK1 Inhibitor LY2606368 in Patients With Advanced Solid Tumors Exhibiting Replicative Stress or Homologous Recombination Repair Deficiency

Massachusetts

Drug(s) in Trial	Other Drug Names	Main Known Action
Prexasertib	checkpoint kinase 1 inhibitor LY2606368, LY2606368	Chk1/2 inhibitor

II

Platinum resistant, refractory or persistent ovarian cancer (disease outside the peritoneal cavity)

A Randomized Phase II Trial of a Genetically Engineered NIS-Expressing Strain of Measles Virus Versus Investigator's Choice Chemotherapy for Patients With Platinum-Resistant Ovarian, Fallopian, or Peritoneal Cancer

Arizona, Florida, Minnesota

Drug(s) in Trial	Other Drug Names	Main Known Action
MV-NIS	oncolytic measles virus encoding thyroidal sodium iodide symporter	Induces immune response and tumor cell lysis

II

Advanced NY-ESO-1+ solid tumors

Adoptive Transfer of NY-ESO-1 TCR Engineered Peripheral Blood Mononuclear Cells (PBMC) After a Nonmyeloablative Conditioning Regimen, With Administration of NY-ESO-1157-165 Pulsed Dendritic Cells and Interleukin-2, in Patients With Advanced Malignancies

California

Drug(s) in Trial	Other Drug Names	Main Known Action
Cyclophosphamide	Ciclofosfamida, Ciclofosfamide, Claphene, CP monohydrate, CPM, Cyclophospham, Cyclophosphamid monohydrate, Cyclophosphamidum, Cyclophosphan, Cyclophosphanum, Cytophosphane, Mitoxan, Syklofosfamid, Zytoxan, Clafen, Cytoxan, Neosar, Carloxan, Cicloxal, Cycloblastin, Cycloblastine, CYCLO-cell, Cyclostin, Cyclostine, Cytophosphan, Endoxan, Endoxana, Enduxan, Fosfaseron, Genoxal, Ledoxina, Procytox, Sendoxan	DNA damaging agent
Fludarabine	Fludara Oral, 2-F-ara-AMP, Beneflur	DNA synthesis inhibitor
NY-ESO-1 reactive TCR retroviral vector transduced autologous PBL	anti-NY-ESO-1 TCR gene-engineered lymphocytes	Immune response against cancer expressing NY-ESO-1
NY-ESO-1(157-165) peptide-pulsed autologous dendritic cell vaccine		Immune response against cancer expressing NY-ESO-1

II

Platinum resistant or refractory ovarian cancer

Pilot Study of the Pre-Conditioning Effects of Anti-Macrophage Therapy Using PD 0360324 in Recurrent Platinum-Resistant Epithelial Ovarian Cancer

Texas

Drug(s) in Trial	Other Drug Names	Main Known Action
Cyclophosphamide	Ciclofosfamida, Ciclofosfamide, Claphene, CP monohydrate, CPM, Cyclophospham, Cyclophosphamid monohydrate, Cyclophosphamidum, Cyclophosphan, Cyclophosphanum, Cytophosphane, Mitoxan, Syklofosfamid, Zytoxan, Clafen, Cytoxan, Neosar, Carloxan, Cicloxal, Cycloblastin, Cycloblastine, CYCLO-cell, Cyclostin, Cyclostine, Cytophosphan, Endoxan, Endoxana, Enduxan, Fosfaseron, Genoxal, Ledoxina, Procytox, Sendoxan	DNA damaging agent
PD-0360324	anti–M-CSF mAb PD-0360324, anti-CSF1 monoclonal antibody PD-0360324	CSF1R antagonist and tumor-associated macrophage inhibitor

II

Advanced solid tumors (in expansion)

Phase I-Ib/II Open-label Multi-center Study of the Safety and Efficacy of MBG453 as Single Agent and in Combination With PDR001 in Adult Patients With Advanced Malignancies

Maryland, Massachusetts, Texas

Drug(s) in Trial	Other Drug Names	Main Known Action
MBG453	Anti-TIM-3 Monoclonal Antibody MBG453, Anti-TIM3 Checkpoint Inhibitor MBG453	Blocks TIM-3 inhibition of T cells
Spartalizumab	anti-PD-1 monoclonal antibody PDR001	Blocks PD-L1/2 inhibition of T cells

II

Advanced ovarian germ cell, mucinous, squamous cell, or adenocarcinoma

DART: Dual Anti-CTLA-4 and Anti-PD-1 Blockade in Rare Tumors

Alabama, Alaska, Arizona, Arkansas, California, Colorado, Connecticut, Delaware, District of Columbia, Florida, Georgia, Hawaii, Idaho, Illinois, Indiana, Iowa, Kansas, Kentucky, Louisiana, Maine, Maryland, Massachusetts, Michigan, Minnesota, Mississippi, Missouri, Montana, Nebraska, Nevada, New Hampshire, New Jersey, New Mexico, New York, North Carolina, North Dakota, Ohio, Oklahoma, Oregon, Pennsylvania, South Carolina, South Dakota, Tennessee, Texas, Utah, Vermont, Virginia, Washington, West Virginia, Wisconsin, Wyoming

Drug(s) in Trial	Other Drug Names	Main Known Action
Ipilimumab	Anti-Cytotoxic T-Lymphocyte-Associated Antigen-4 Monoclonal Antibody, MDX-010, Yervoy	Blocks CTLA-4 inhibition of T cells
Nivolumab	BMS-936558, ONO-4538, MDX-1106, Anti-PD-1 human mab MDX-1106, Opdivo	Blocks PD-L1/2 inhibition of T cells

II

Platinum resistant or refractory ovarian cancer (< 3 prior therapies for platinum resistant disease)

Phase II Randomized Study of Pembrolizumab With or Without Epigenetic Modulation With CC-486 in Patients With Platinum-resistant Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer

California, Maryland, Minnesota

Drug(s) in Trial	Other Drug Names	Main Known Action
Oral Azacitidine	CC-486	DNA methylation inhibitor
Pembrolizumab	MK3475, SCH 900475, Lambrolizumab, Keytruda	Blocks PD-L1/2 inhibition of T cells

II

Advanced solid tumors with lesion treatable with radiotherapy

Randomized Phase II Study of Checkpoint Blockade Immunotherapy Combined With Stereotactic Body Radiation Therapy in Advanced Metastatic Disease

California

Drug(s) in Trial	Other Drug Names	Main Known Action
Atezolizumab	RG7446, MPDL3280A, Anti-PD-L1 Monoclonal Antibody MPDL3280A, Tecentriq	Blocks PD-L1 inhibition of T cells
Ipilimumab	Anti-Cytotoxic T-Lymphocyte-Associated Antigen-4 Monoclonal Antibody, MDX-010, Yervoy	Blocks CTLA-4 inhibition of T cells
Nivolumab	BMS-936558, ONO-4538, MDX-1106, Anti-PD-1 human mab MDX-1106, Opdivo	Blocks PD-L1/2 inhibition of T cells
Pembrolizumab	MK3475, SCH 900475, Lambrolizumab, Keytruda	Blocks PD-L1/2 inhibition of T cells

II

Platinum resistant or refractory ovarian cancer

Randomized Phase II Trial of Durvalumab (MEDI4736) and Tremelimumab Administered in Combination Versus Sequentially in Recurrent Platinum-Resistant Epithelial Ovarian Cancer

Texas

Drug(s) in Trial	Other Drug Names	Main Known Action
Durvalumab	Anti-B7H1 Monoclonal Antibody MEDI4736, MEDI4736, Imfinzi	Blocks PD-L1 inhibition of T cells
Tremelimumab	anti-CTLA4 human monoclonal antibody CP-675,206, CP-675, CP-675,206, CP-675206, Ticilimumab	Blocks CTLA-4 inhibition of T cells

II

Platinum resistant, refractory or persistent ovarian cancer

A Randomized Phase II Evaluation of Weekly Ixabepilone With or Without Biweekly Bevacizumab in Recurrent or Persistent Platinum-resistant/Refractory Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancers

Connecticut, Maryland

Drug(s) in Trial	Other Drug Names	Main Known Action
Bevacizumab	immunoglobulin G1 (human-mouse monoclonal rhuMab-VEGF gamma-chain, anti-VEGF monoclonal antibody, Avastin	VEGF antagonist
Ixabepilone	Azaepothilone B, BMS-247550, epothilone B lactam, Epothilone-B, Ixempra	Microtubule stabilizer/mitotic inhibitor

II

Advanced solid tumors with NTRK1-3 rearrangements

A Phase II Study of Merestinib in Non-Small Cell Lung Cancers Harboring MET Exon 14 Mutations and Solid Tumors With NTRK Rearrangements

Massachusetts

Drug(s) in Trial	Other Drug Names	Main Known Action
Merestinib	c-Met inhibitor LY2801653, LY2801653	Multi-targeted RTK inhibitor

II

Advanced solid tumors (in expansion)

A Phase 1/2 Study of INCB053914 in Subjects With Advanced Malignancies

Arizona, California, Connecticut, Florida, Georgia, Maryland, Massachusetts, Michigan, Nebraska, Ohio, Oklahoma, Tennessee, Texas, Wisconsin

Drug(s) in Trial	Other Drug Names	Main Known Action
Azacytidine	azacitidine, Vidaza, Mylosar, 5-AZC	DNA methylation inhibitor
INCB053914	pan-PIM inhibitor INCB053914	PIM1, 2, 3 inhibitor

II

Advanced high grade serous, clear cell, or endometrioid ovarian cancer

A Randomized, Intra-patient Crossover, Safety, Biomarker and Anti-Tumor Activity Assessment of the Combination of Atezolizumab and Vigil in Patients With Advanced Gynecological Cancers

Alabama, Georgia, Montana, New Hampshire, South Carolina

Drug(s) in Trial	Other Drug Names	Main Known Action
Atezolizumab	RG7446, MPDL3280A, Anti-PD-L1 Monoclonal Antibody MPDL3280A, Tecentriq	Blocks PD-L1 inhibition of T cells
Gemogenovatucel-T	Vigil, bi-shRNA-furin/GMCSF-expressing autologous tumor cell vaccine, bi-shRNA-furin and granulocyte macrophage colony stimulating factor augmented autologous tumor cell vaccine, FANG vaccine	Immune cell stimulator and TGFbeta inhibitor

II

Platinum resistant ovarian cancer (<4 prior cytotoxic therapies)

P53MVA and Pembrolizumab in Treating Patients With Recurrent Ovarian, Primary Peritoneal, or Fallopian Tube Cancer

California

Drug(s) in Trial	Other Drug Names	Main Known Action
MVA-p53 vaccine	Modified Vaccinia Virus Ankara Vaccine Expressing p53, p53MVA, p53MVA vaccine	Immune response against p53 tumor antigen
Pembrolizumab	MK3475, SCH 900475, Lambrolizumab, Keytruda	Blocks PD-L1/2 inhibition of T cells

II

Advanced solid tumors with IDH1 or IDH2 mutations

A Phase 2 Study of the PARP Inhibitor Olaparib (AZD2281) in IDH1 and IDH2 Mutant Advanced Solid Tumors

California, Connecticut, District of Columbia, Maryland, Massachusetts, New Jersey, North Carolina, Ohio, Pennsylvania, Tennessee, Texas

Drug(s) in Trial	Other Drug Names	Main Known Action
Olaparib	AZD2281, Lynparza	PARP inhibitor

II

Advanced solid tumors with CCNE1 AMP

A Phase 2 Study of AZD1775, a Wee1 Inhibitor, in Patients With CCNE1 Amplification

California, Colorado, Kentucky, New York, North Carolina, Pennsylvania, Texas

Drug(s) in Trial	Other Drug Names	Main Known Action
Adavosertib	WEE1 inhibitor AZD1775, MK1775, AZD1775	WEE1 inhibitor

II

Advanced solid tumors

Evaluating Immune Checkpoint Inhibition In Solid Tumor Patients With Homologous Recombination Repair Deficiency

Florida

Drug(s) in Trial	Other Drug Names	Main Known Action
Pembrolizumab	MK3475, SCH 900475, Lambrolizumab, Keytruda	Blocks PD-L1/2 inhibition of T cells

II

Advanced solid tumors with SETD2 deficiency

A Phase 2 Study of AZD1775 in SETD2-Deficient Advanced Solid Tumor Malignancies

California, District of Columbia, Maryland, Massachusetts, Missouri, Pennsylvania, Tennessee

Drug(s) in Trial	Other Drug Names	Main Known Action
Adavosertib	WEE1 inhibitor AZD1775, MK1775, AZD1775	WEE1 inhibitor

II

Advanced solid tumors (with resectable tumor)

A Phase II Trial to Evaluate the Ability of a Dendritic Cell Vaccine to Immunize Melanoma or Epithelial Cancer Patients Against Defined Mutated Neoantigens Expressed by the Autologous Cancer

Maryland

Drug(s) in Trial	Other Drug Names	Main Known Action
Peptide loaded dendritic cell vaccine		Anti-tumor immune response

II

Advanced solid tumors with CCND1, CCND2, or CCND3 alterations or CDK4/6 amplifications

A Phase II Study of the CDK4/6 Inhibitor Abemaciclib in Patients With Solid Tumors Harboring Genetic Alterations in Genes Encoding D-type Cyclins or Amplification of CDK4 or CDK6

Massachusetts

Drug(s) in Trial	Other Drug Names	Main Known Action
Abemaciclib	Verzenio, CDK4/6 Dual Inhibitor LY2835219, LY2853219, Bemaciclib	CDK4/6 inhibitor

II

Recurrent clear cell ovarian cancer

BrUOG 354: A Phase II Randomized Trial of Nivolumab +/- Ipilimumab for Ovarian and Extra-renal Clear Cell Carcinomas

Rhode Island

Drug(s) in Trial	Other Drug Names	Main Known Action
Ipilimumab	Anti-Cytotoxic T-Lymphocyte-Associated Antigen-4 Monoclonal Antibody, MDX-010, Yervoy	Blocks CTLA-4 inhibition of T cells
Nivolumab	BMS-936558, ONO-4538, MDX-1106, Anti-PD-1 human mab MDX-1106, Opdivo	Blocks PD-L1/2 inhibition of T cells

II

Platinum resistant or refractory ovarian cancer

Phase 2 Study of Combination of Nivolumab and Ipilimumab in (1) Neoadjuvant Setting in Previously Untreated Breast Cancer Patients, (2) Platinum-Resistant/Refractory Advanced Ovarian Cancer Patients; and (3) Advanced Gastric Cancer Patients

Georgia, New York

Drug(s) in Trial	Other Drug Names	Main Known Action
Ipilimumab	Anti-Cytotoxic T-Lymphocyte-Associated Antigen-4 Monoclonal Antibody, MDX-010, Yervoy	Blocks CTLA-4 inhibition of T cells
Nivolumab	BMS-936558, ONO-4538, MDX-1106, Anti-PD-1 human mab MDX-1106, Opdivo	Blocks PD-L1/2 inhibition of T cells

II

Advanced solid tumors with MET over-expression or mutation

A Phase 2 Study of AMG 337 in Subjects With Advanced or Metastatic Solid Tumors That Overexpress Mesenchymal Epithelial Transition (MET) or Harbor MET Exon 14 Skipping (METex14del) Mutations

California

Drug(s) in Trial	Other Drug Names	Main Known Action
AMG 337		c-Met kinase inhibitor

II

Platinum resistant or refractory ovarian cancer

A Phase 2 Study Evaluating the Efficacy and Safety of DKN-01 as a Monotherapy or in Combination With Paclitaxel in Patients With Recurrent Epithelial Endometrial or Epithelial Ovarian Cancer

Alabama, Arizona, Florida, Massachusetts, Missouri, Ohio, Oklahoma, Tennessee, Texas, Virginia, Wisconsin

Drug(s) in Trial	Other Drug Names	Main Known Action
DKN-01	DKK1-neutralizing monoclonal antibody DKN-01	Dickkopf-1 (DKK1) antagonist
Paclitaxel	Anzatax, Asotax, Bristaxol, Praxel, Taxol, Taxol Konzentrat, TXL	Microtubule stabilizer/mitotic inhibitor

II

Advanced solid tumors with positive MSI or tumors with negative MSI and high TMB

Phase 2 Study of MK-3475 in Patients With Microsatellite Unstable (MSI) Tumors

California, Maryland, Ohio, Oregon, Pennsylvania

Drug(s) in Trial	Other Drug Names	Main Known Action
Pembrolizumab	MK3475, SCH 900475, Lambrolizumab, Keytruda	Blocks PD-L1/2 inhibition of T cells

II

Platinum resistant or refractory high grade serous ovarian cancer

A Phase 2 Study of Prexasertib in Platinum-Resistant or Refractory Recurrent Ovarian Cancer

Arizona, California, Florida, Massachusetts, Missouri, New Hampshire, Oklahoma, Pennsylvania, Rhode Island, South Dakota, Tennessee, Washington

Drug(s) in Trial	Other Drug Names	Main Known Action
Prexasertib	checkpoint kinase 1 inhibitor LY2606368, LY2606368	Chk1/2 inhibitor

II

Advanced solid tumors with POLE, POLD, or BRCA1/2 mutations

A Basket Trial of Pembrolizumab in Patients With Advanced Solid Tumors and Genomic Instability

New Jersey

Drug(s) in Trial	Other Drug Names	Main Known Action
Pembrolizumab	MK3475, SCH 900475, Lambrolizumab, Keytruda	Blocks PD-L1/2 inhibition of T cells

II

Advanced solid tumors with CDK12 alterations

IMPACT: Immunotherapy in Patients With Metastatic Cancers and CDK12 Mutations

Michigan

Drug(s) in Trial	Other Drug Names	Main Known Action
Ipilimumab	Anti-Cytotoxic T-Lymphocyte-Associated Antigen-4 Monoclonal Antibody, MDX-010, Yervoy	Blocks CTLA-4 inhibition of T cells
Nivolumab	BMS-936558, ONO-4538, MDX-1106, Anti-PD-1 human mab MDX-1106, Opdivo	Blocks PD-L1/2 inhibition of T cells

II

Advanced solid tumors with BRCA1/2 or ATM mutations

A Phase 2 Study To Evaluate Safety And Anti-tumor Activity Of Avelumab In Combination With Talazoparib In Patients With Brca Or Atm Mutant Tumors

California, Georgia, Louisiana, Massachusetts, Missouri, New Jersey, New York, Oklahoma, Pennsylvania, Tennessee, Texas

Drug(s) in Trial	Other Drug Names	Main Known Action
Avelumab	Anti programmed death ligand 1 monoclonal antibody, Anti-PD-L1, MSB0010718C, Bavencio	Blocks PD-L1 inhibition of T cells
Talazoparib	Talazoparib Tosylate, BMN-673, MDV3800	PARP inhibitor

II

Platinum resistant or refractory ovarian cancer (PD on prior PARP inhibitor)

A Randomized 2-Arm, Non-Comparative Phase 2 Study of AZD1775 Alone or AZD1775 and Olaparib in Ovarian Cancer Patients Who Have Progressed During PARP Inhibition

Massachusetts, Texas

Drug(s) in Trial	Other Drug Names	Main Known Action
Adavosertib	WEE1 inhibitor AZD1775, MK1775, AZD1775	WEE1 inhibitor
Olaparib	AZD2281, Lynparza	PARP inhibitor

II

Recurrent or refractory high grade serous ovarian cancer or carcinosarcoma

Clinical Study to Assess Efficacy and Safety of MDA-TIL (Autologous Expanded Tumor Infiltrating Lymphocytes) Across Multiple Tumor Types

Texas

Drug(s) in Trial	Other Drug Names	Main Known Action
MDA-TIL	autologous tumor-infiltrating lymphocytes MDA-TIL	Anti-tumor immune response

II

Recurrent ovarian cancer with high MSI

An Exploratory Study of Nivolumab With or Without Ipilimumab According to the Percentage of Tumoral CD8 Cells in Participants With Advanced Metastatic Cancer

California, Texas

Drug(s) in Trial	Other Drug Names	Main Known Action
Ipilimumab	Anti-Cytotoxic T-Lymphocyte-Associated Antigen-4 Monoclonal Antibody, MDX-010, Yervoy	Blocks CTLA-4 inhibition of T cells
Nivolumab	BMS-936558, ONO-4538, MDX-1106, Anti-PD-1 human mab MDX-1106, Opdivo	Blocks PD-L1/2 inhibition of T cells

II

Advanced solid tumors with high TMB

A Randomized, Open-Label, Phase 2 Study of Nivolumab in Combination With Ipilimumab or Nivolumab Monotherapy in Participants With Advanced or Metastatic Solid Tumors of High Tumor Mutational Burden (TMB-H)

California, Colorado, Florida, Illinois, Indiana, Minnesota, New Jersey, New York, North Carolina, Oregon, Tennessee, Texas

Drug(s) in Trial	Other Drug Names	Main Known Action
Ipilimumab	Anti-Cytotoxic T-Lymphocyte-Associated Antigen-4 Monoclonal Antibody, MDX-010, Yervoy	Blocks CTLA-4 inhibition of T cells
Nivolumab	BMS-936558, ONO-4538, MDX-1106, Anti-PD-1 human mab MDX-1106, Opdivo	Blocks PD-L1/2 inhibition of T cells

II

Platinum resistant or refractory mesothelin+ high grade serous or endometroid ovarian cancer

A Randomized Phase 2 Study of Bevacizumab and Either Weekly Anetumab Ravtansine or Weekly Paclitaxel in Platinum-Resistant or Platinum Refractory Ovarian Cancer

Ohio

Drug(s) in Trial	Other Drug Names	Main Known Action
Anetumab ravtansine	BAY 94-9343, Anti-mesothelin Antibody-Drug Conjugate BAY 94-9343	ADC: anti-mesothelin + microtubule destabilizer (DM4)
Bevacizumab	immunoglobulin G1 (human-mouse monoclonal rhuMab-VEGF gamma-chain, anti-VEGF monoclonal antibody, Avastin	VEGF antagonist
Paclitaxel	Anzatax, Asotax, Bristaxol, Praxel, Taxol, Taxol Konzentrat, TXL	Microtubule stabilizer/mitotic inhibitor

II

Recurrent ovarian cancer

Phase II Trial of AZD6738 Alone and in Combination With Olaparib in Patients With Selected Solid Tumor Malignancies

California

Drug(s) in Trial	Other Drug Names	Main Known Action
AZD6738		ATR kinase inhibitor
Olaparib	AZD2281, Lynparza	PARP inhibitor

II

Advanced solid cancer with ATM truncation mutations or other HR gene mutations

A Phase II Study of M6620 (VX-970) in Selected Solid Tumors

Massachusetts

Drug(s) in Trial	Other Drug Names	Main Known Action
Berzosertib	VX-970, M6620, VE-822, ATR kinase inhibitor VX-970	ATR kinase inhibitor

II

Low grade serous ovarian cancer

A Phase II Trial of Ribociclib (LEE011) Plus Letrozole in Women With Recurrent Low-Grade Serous Carcinoma of the Ovary or Peritoneum

Contact Research Staff

Drug(s) in Trial	Other Drug Names	Main Known Action
Letrozole	Femara	Aromatase inhibitor
Ribociclib	Kisqali, CDK4/6 Inhibitor LEE011, LEE011, Kisqali	CDK4/6 inhibitor

II

Advanced solid tumors with POLE and/or POLD1 mutations

A Phase II Open Label, Randomized Non-Comparative Trial of Nivolumab Alone or in Combination With Ipilimumab for the Treatment of Patients With Advanced Hypermutated Solid Tumors Detected by a Blood Based Assay

New York

Drug(s) in Trial	Other Drug Names	Main Known Action
Ipilimumab	Anti-Cytotoxic T-Lymphocyte-Associated Antigen-4 Monoclonal Antibody, MDX-010, Yervoy	Blocks CTLA-4 inhibition of T cells
Nivolumab	BMS-936558, ONO-4538, MDX-1106, Anti-PD-1 human mab MDX-1106, Opdivo	Blocks PD-L1/2 inhibition of T cells

II

Platinum resistant or refractory ovarian cancer

A Phase 2, Randomized, Open-Label, 3-arm Study of Relacorilant in Combination With Nab-Paclitaxel for Patients With Recurrent Platinum-Resistant Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

Arizona

Drug(s) in Trial	Other Drug Names	Main Known Action
nab-Paclitaxel	Paclitaxel Albumin-Stabilized Nanoparticle Formula, Abraxane, ABI-007	Microtubule stabilizer/mitotic inhibitor
Relacorilant	CORT125134	GR antagonist

II

Advanced solid tumors with a FGFR1, FGFR2 or FGFR3 fusion

A Phase II Basket Study of the Oral Selective Pan-FGFR Inhibitor Debio 1347 in Subjects With Solid Tumors Harboring a Fusion of FGFR1, FGFR2 or FGFR3

Arizona, California, Florida, Louisiana, Maryland, Massachusetts, New Jersey, New York, North Carolina, Ohio, Texas, Washington, Wisconsin

Drug(s) in Trial	Other Drug Names	Main Known Action
Debiopharm 1347	CH5183284, FF284, FGFR Inhibitor Debio 1347	FGFR1-3 inhibitor

II

Epithelial ovarian cancer (with tumor lesions < 5 cm)

A Phase 2, Open-label, Multicenter, Study of an Immunotherapeutic Treatment, DPX-Survivac in Combination With Low Dose Cyclophosphamide and Pembrolizumab, in Subjects With Selected Advanced and Recurrent Solid Tumours.

New York, Texas

Drug(s) in Trial	Other Drug Names	Main Known Action
Cyclophosphamide	Ciclofosfamida, Ciclofosfamide, Claphene, CP monohydrate, CPM, Cyclophospham, Cyclophosphamid monohydrate, Cyclophosphamidum, Cyclophosphan, Cyclophosphanum, Cytophosphane, Mitoxan, Syklofosfamid, Zytoxan, Clafen, Cytoxan, Neosar, Carloxan, Cicloxal, Cycloblastin, Cycloblastine, CYCLO-cell, Cyclostin, Cyclostine, Cytophosphan, Endoxan, Endoxana, Enduxan, Fosfaseron, Genoxal, Ledoxina, Procytox, Sendoxan	DNA damaging agent
DPX-Survivac	survivin antigen vaccine DPX-Survivac	Immune response against cancer expressing survivin
Pembrolizumab	MK3475, SCH 900475, Lambrolizumab, Keytruda	Blocks PD-L1/2 inhibition of T cells

Ib/II

Advanced solid tumors

A Phase 1b/2 Study of AST-008 Combined With Pembrolizumab in Patients With Advanced Solid Tumors

California, Florida, Iowa, Massachusetts

Drug(s) in Trial	Other Drug Names	Main Known Action
AST-008	TLR9 agonist AST-008	TLR agonist and immune cell stimulator
Pembrolizumab	MK3475, SCH 900475, Lambrolizumab, Keytruda	Blocks PD-L1/2 inhibition of T cells

Ib/II

Advanced solid tumors with IDH1 mutations (inc expansion)

A Phase 1b/2 Study of FT 2102 in Participants With Advanced Solid Tumors and Gliomas With an IDH1 Mutation

Florida

Drug(s) in Trial	Other Drug Names	Main Known Action
FT-2102		mutated IDH1 inhibitor

Ib/II

Advanced solid tumors

An Open-Label, Multicenter, Phase 1b/2 Study of Rebastinib (DCC-2036) in Combination With Paclitaxel to Assess Safety, Tolerability, and Pharmacokinetics in Patients With Advanced or Metastatic Solid Tumors

Alabama, New York, Oklahoma, Pennsylvania, Tennessee, Texas

Drug(s) in Trial	Other Drug Names	Main Known Action
Paclitaxel	Anzatax, Asotax, Bristaxol, Praxel, Taxol, Taxol Konzentrat, TXL	Microtubule stabilizer/mitotic inhibitor
Rebastinib	multitargeted tyrosine kinase inhibitor DCC-2036	Multi-targeted kinase inhibitor

Ib/II

Platinum resistant, refractory or partially sensitive ovarian cancer (with peritoneal disease)

Phase 1b & 2 Study With GL-ONC1 Oncolytic Immunotherapy in Patients With Recurrent or Refractory Ovarian Cancer (VIRO-15)

California, Florida

Drug(s) in Trial	Other Drug Names	Main Known Action
Bevacizumab	immunoglobulin G1 (human-mouse monoclonal rhuMab-VEGF gamma-chain, anti-VEGF monoclonal antibody, Avastin	VEGF antagonist
Carboplatin	Paraplatin, Novoplatinum	DNA damaging agent
Docetaxel	Taxotere	Microtubule stabilizer/mitotic inhibitor
Gemcitabine	Gemzar	Ribonucleotide reductase and DNA synthesis inhibitor
GL-ONC1	light-emitting oncolytic vaccinia virus GL-ONC1	Membrane disrupter
Liposomal doxorubicin	Doxil, Dox-SL, Evacet, LipoDox, liposomal doxorubicin, Pegylated Liposomal Doxorubicin Hydrochloride	Topoisomerase II inhibitor
Paclitaxel	Anzatax, Asotax, Bristaxol, Praxel, Taxol, Taxol Konzentrat, TXL	Microtubule stabilizer/mitotic inhibitor

Ib/II

Advanced FRalpha+ ovarian cancer

A Phase 1b/2 Study to Evaluate the Safety, Tolerability and Pharmacokinetics of Mirvetuximab Soravtansine (IMGN853) in Combination With Bevacizumab, Carboplatin, Pegylated Liposomal Doxorubicin, Pembrolizumab, or Bevacizumab+Carboplatin in Adults With Folate Receptor Alpha Positive Advanced Epithelial Ovarian Cancer, Primary Peritoneal Cancer or Fallopian Tube Cancer

Massachusetts, Ohio, Oklahoma, Pennsylvania

Drug(s) in Trial	Other Drug Names	Main Known Action
Bevacizumab	immunoglobulin G1 (human-mouse monoclonal rhuMab-VEGF gamma-chain, anti-VEGF monoclonal antibody, Avastin	VEGF antagonist
Mirvetuximab Soravtansine	M9346A-sulfo-SPDB-DM4, IMGN853, Anti-FOLR1-mab Maytansinoid Conjugate	ADC: anti-FOLR1 + microtubule destabilizer (DM4)

Ib

Advanced solid tumors

A Phase Ib Study of AZD1775 and Olaparib in Patients With Refractory Solid Tumours

Colorado, Florida, New York, Tennessee, Texas

Drug(s) in Trial	Other Drug Names	Main Known Action
Adavosertib	WEE1 inhibitor AZD1775, MK1775, AZD1775	WEE1 inhibitor
Olaparib	AZD2281, Lynparza	PARP inhibitor

Ib

Advanced solid tumors

A Phase 1b Study of the Safety, Pharmacokinetics, and Preliminary Antitumor Activity of ACY 241 in Combination With Paclitaxel in Patients With Advanced Solid Tumors

Massachusetts

Drug(s) in Trial	Other Drug Names	Main Known Action
ACY-241	HDAC inhibitor ACY-241, histone deacetylase inhibitor ACY-241	HDAC inhibitor
Paclitaxel	Anzatax, Asotax, Bristaxol, Praxel, Taxol, Taxol Konzentrat, TXL	Microtubule stabilizer/mitotic inhibitor

Ib

Advanced solid tumors

A Phase Ib Open‑Label, Dose‑Finding Trial to Evaluate the Safety, Tolerability, and Pharmacokinetics of Avelumab in Combination With M9241(NHS-IL12) in Subjects With Locally Advanced, Unresectable, or Metastatic Solid Tumors

California, Connecticut, Florida, Louisiana, Maryland, Minnesota, Missouri, Ohio, Oklahoma, Oregon, South Carolina, Texas, Vermont, Washington

Drug(s) in Trial	Other Drug Names	Main Known Action
Avelumab	Anti programmed death ligand 1 monoclonal antibody, Anti-PD-L1, MSB0010718C, Bavencio	Blocks PD-L1 inhibition of T cells
NHS-IL12	M9241, immunocytokine NHS-IL12	IL-12 receptor agonist

Ib

Recurrent or persistent ovarian cancer

Prospective Phase Ib Clinical Trial to Evaluate the Safety and Efficacy of Oregovomab and Hiltonol® as a Combinatorial Immunotherapy Strategy in Patients With Recurrent Advanced Epithelial Cancer of Ovarian, Tubal, or Peritoneal Origin

Florida, Virginia

Drug(s) in Trial	Other Drug Names	Main Known Action
Oregovomab	OvaRex, Monoclonal Antibody B43.13, B43.13	Immune response against cancer expressing CA125
poly ICLC	poly I:poly C with poly-1-lysine stabilizer, Polyinosinic-Polycytidylic Acid Stabilized with Polylysine and Carboxymethylcellulose, Hiltonol, poly-ICLC	Activates dendritic cells and induces interferon production

Ib

Advanced solid tumors (inc ovarian expansion)

Phase Ib Study to Test the Safety and Potential Synergy of Pembrolizumab (Anti-PD-1) and AMG386 (Angiopoietin-2 (Ang-2) in Patients With Advanced Solid Tumor

Massachusetts

Drug(s) in Trial	Other Drug Names	Main Known Action
Pembrolizumab	MK3475, SCH 900475, Lambrolizumab, Keytruda	Blocks PD-L1/2 inhibition of T cells
Trebananib	AMG 386	Angiopoietin 1/2 antagonist

Ib

Advanced solid tumors

An Open Label, Phase Ib, Dose-escalation Study Evaluating the Safety and Tolerability of Xentuzumab and Abemaciclib in Patients With Locally Advanced or Metastatic Solid Tumours and in Combination With Endocrine Therapy in Patients With Locally Advanced or Metastatic Hormone Receptor-positive, HER2-, Breast Cancer, Followed by Expansion Cohorts.

California, Connecticut, Minnesota, Nevada, North Carolina

Drug(s) in Trial	Other Drug Names	Main Known Action
Abemaciclib	Verzenio, CDK4/6 Dual Inhibitor LY2835219, LY2853219, Bemaciclib	CDK4/6 inhibitor
Xentuzumab	BI-836845	IGF-1/2 antagonist

Ib

Advanced solid tumors (inc expansion)

A Phase 1b, Open-Label, Dose-Escalation and Dose-Expansion Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Antitumor Activity of Camidanlumab Tesirine (ADCT-301) in Patients With Selected Advanced Solid Tumors

California, Connecticut, New York, Tennessee, Texas

Drug(s) in Trial	Other Drug Names	Main Known Action
Camidanlumab Tesirine	anti-CD25-PBD antibody-drug conjugate ADCT-301, ADCT-301	DNA damaging agent

Ib

Recurrent ovarian cancer with BRCA1/2 mutations (or high grade serous with BRCA1/2 WT)(inc expansion)

A Phase Ib Study of the Oral PARP Inhibitor Niraparib With the Intravenous PI3K Inhibitor Copanlisib for Recurrent Endometrial and Recurrent Ovarian, Primary Peritoneal, or Fallopian Tube Cancer

Texas

Drug(s) in Trial	Other Drug Names	Main Known Action
Copanlisib	BAY 80-6946, MEK inhibitor BAY 80-6946, PI3K inhibitor BAY 80-6946	pan-PI3K inhibitor
Niraparib	MK4827, Zejula	PARP inhibitor

Ib

Advanced solid tumors (inc expansion)

A Phase 1b Study of INCMGA00012 in Combination With Other Therapies in Patients With Advanced Solid Tumors

California, Illinois, North Carolina, Pennsylvania, Texas, Washington

Drug(s) in Trial	Other Drug Names	Main Known Action
Epacadostat	3-dioxygenase Inhibitor INCB024360, Indoleamine-2,3-dioxygenase Inhibitor INCB024360, INCB024360, IDO1 Inhibitor INCB024360	Inhibits IDO to stimulate immune response
INCB050465	PI3K-delta inhibitor INCB050465	PI3K delta inhibitor
MGA012	anti-PD-1 monoclonal antibody MGA012, INCMGA00012	Blocks PD-L1 inhibition of T cells

Ib

Advanced solid tumors (inc ovarian expansion)

A Phase 1b Trial of Hu5F9-G4 in Combination With Avelumab in Solid Tumor Patients and Checkpoint Inhibitor Naïve Ovarian Cancer Patients Who Progress Within 6 Months of Prior Platinum Chemotherapy

Illinois, Michigan, Oklahoma, Texas, Washington

Drug(s) in Trial	Other Drug Names	Main Known Action
Avelumab	Anti programmed death ligand 1 monoclonal antibody, Anti-PD-L1, MSB0010718C, Bavencio	Blocks PD-L1 inhibition of T cells
Hu5F9-G4	anti-CD47 monoclonal antibody Hu5F9-G4	Blocks CD47 signaling to stimulate immune response and tumor cell phagocytosis

Ib

Advanced HER2+ solid tumors (inc expansion)

A Phase 1b, Open-Label, Dose Escalation Study of PRS-343 in Combination With Atezolizumab in Patients With HER2-Positive Advanced or Metastatic Solid Tumors

Texas

Drug(s) in Trial	Other Drug Names	Main Known Action
Atezolizumab	RG7446, MPDL3280A, Anti-PD-L1 Monoclonal Antibody MPDL3280A, Tecentriq	Blocks PD-L1 inhibition of T cells
PRS-343	anti-HER2 monoclonal antibody/anti-CD137 anticalin bispecific fusion protein PRS-343	Immune response against cancer expressing HER2

Ib

Advanced solid tumors

A Phase Ib/II Study of APG-115 in Combination With Pembrolizumab in Patients With Unresectable or Metastatic Melanomas or Advanced Solid Tumors

Texas

Drug(s) in Trial	Other Drug Names	Main Known Action
APG-115	p53-HDM2 protein-protein interaction inhibitor APG-115, MDM2-p53 inhibitor APG-115	MDM2 inhibitor
Pembrolizumab	MK3475, SCH 900475, Lambrolizumab, Keytruda	Blocks PD-L1/2 inhibition of T cells

Ib

Advanced solid tumors

Phase 1b Clinical Study of CBP501, Cisplatin and Nivolumab Administered Every 3 Weeks in Patients With Advanced Refractory Tumors

Arizona, Louisiana, Massachusetts

Drug(s) in Trial	Other Drug Names	Main Known Action
CBP501	G2 checkpoint inhibitor CBP501	G2 checkpoint inhibitor
Cisplatin	CACP, cis-DDP, cis-platinum, CDDP, Platinol, Abiplatin, Blastolem, Briplatin, Cisplatyl, Citoplatino, Citosin, Lederplatin, Metaplatin, Neoplatin, Placis, Platamine, Platiblastin, Platiblastin-S, Platinex, Platinol, Platiran, Platistin, Platosin	DNA damaging agent
Nivolumab	BMS-936558, ONO-4538, MDX-1106, Anti-PD-1 human mab MDX-1106, Opdivo	Blocks PD-L1/2 inhibition of T cells

Ib

Advanced solid tumors (in expansion)

An Open-Label, Multicenter, Dose-Escalation Phase IB Study to Investigate the Safety, Pharmacokinetics, Pharmacodynamics, and Therapeutic Activity of RO7009789 (CD40 Agonist) in Combination With Atezolizumab (Anti PD-L1) in Patients With Locally Advanced and/or Metastatic Solid Tumors

Drug(s) in Trial	Other Drug Names	Main Known Action
Atezolizumab	RG7446, MPDL3280A, Anti-PD-L1 Monoclonal Antibody MPDL3280A, Tecentriq	Blocks PD-L1 inhibition of T cells
Selicrelumab	CD40 agonist monoclonal antibody RO7009789	Stimulates CD40 to increase/activate antigen-presenting cells and enhance immune response

Ib

Advanced solid tumors with BRCA1, BRCA2, ATM, BARD1, BRIP1, CDK12, CHEK2, FANCA, NBN, PALB2, RAD51, RAD51B, RAD51C, RAD51D, or RAD54L mutations (inc expansion)

Combination Therapy of Rucaparib and Irinotecan in Cancers With Mutations in DNA Repair

California

Drug(s) in Trial	Other Drug Names	Main Known Action
Irinotecan	Camptosar, Campto, Campothecin-11	Topoisomerase I inhibitor
Rucaparib	AG-014699, PF 01367338, CO-338, Rubraca	PARP inhibitor

Ib

Advanced solid tumors

Phase 1b Dose-Finding Study of Niraparib, TSR-022, Bevacizumab, and Platinum-Based Doublet Chemotherapy in Combination With TSR-042 in Patients With Advanced or Metastatic Cancer

Arizona, California, Florida, Ohio, Tennessee, Texas

Drug(s) in Trial	Other Drug Names	Main Known Action
Bevacizumab	immunoglobulin G1 (human-mouse monoclonal rhuMab-VEGF gamma-chain, anti-VEGF monoclonal antibody, Avastin	VEGF antagonist
Carboplatin	Paraplatin, Novoplatinum	DNA damaging agent
Niraparib	MK4827, Zejula	PARP inhibitor
Paclitaxel	Anzatax, Asotax, Bristaxol, Praxel, Taxol, Taxol Konzentrat, TXL	Microtubule stabilizer/mitotic inhibitor
TSR-022		Blocks TIM-3 inhibition of T cells
TSR-042	ANB011, anti-PD-1 monoclonal antibody TSR-042	Blocks PD-L1/2 inhibition of T cells

Ib

Advanced solid tumors

A Phase 1b/2 Dose-Escalation and Expansion Trial of NC-6300 (Nanoparticle Epirubicin) in Patients With Advanced Solid Tumors or Advanced, Metastatic, or Unresectable Soft Tissue Sarcoma

California, Indiana, Missouri, Nevada, New York, North Carolina

Drug(s) in Trial	Other Drug Names	Main Known Action
NC-6300	epirubicin-incorporating micelle, epirubicin-conjugated polymer micelles, nanoparticle epirubicin, micellar nanoparticle-encapsulated epirubicin, K-912	Topoisomerase II inhibitor

Ib

Advanced solid tumors

A Phase 1b Study of ASP8374, an Immune Checkpoint Inhibitor, as a Single Agent and in Combination With Pembrolizumab in Subjects With Advanced Solid Tumors

Arizona, California, Florida, Iowa, Kansas, New York, Pennsylvania, Tennessee, Virginia

Drug(s) in Trial	Other Drug Names	Main Known Action
ASP8374	PTZ-201	Blocks T cell binding to CD112 and CD155 to enable activation of CD226 signaling in NK and CD8 T cells
Pembrolizumab	MK3475, SCH 900475, Lambrolizumab, Keytruda	Blocks PD-L1/2 inhibition of T cells

Ib

Advanced solid tumors with high MSI or dMMR

Phase Ib Trial of L-NMMA in Combination With Pembrolizumab in Patients With Melanoma, Non-Small Cell Lung Cancer, Head and Neck Squamous Cell Carcinoma, Classical Hodgkin Lymphoma, Urothelial Carcinoma, or Microsatellite Instability-High/Mismatch Repair Deficient Cancer

Texas

Drug(s) in Trial	Other Drug Names	Main Known Action
L-NMMA	pan-nitric oxide synthase inhibitor, NG-monomethyl-L-arginine	NOS inhibitor
Pembrolizumab	MK3475, SCH 900475, Lambrolizumab, Keytruda	Blocks PD-L1/2 inhibition of T cells

Ia/Ib

Advanced solid tumors (inc ovarian expansion)

A Phase 1a/1b Study of FPA150, an Anti-B7-H4 Antibody, in Patients With Advanced Solid Tumors

Arizona, California, Connecticut, Michigan, Tennessee, Texas

Drug(s) in Trial	Other Drug Names	Main Known Action
FPA150	anti-B7-H4 monoclonal antibody FPA150	Immune response against cancer expressing B7-H4, blocks B7-H4 inhibition of T cells

Ia/Ib

Advanced solid tumors (inc expansion)

A Phase Ia/Ib, Open Label, Multicenter, Dose-escalation Study of BI 907828 in Patients With Advanced or Metastatic Solid Tumors

Connecticut, Florida, New York, Tennessee

Drug(s) in Trial	Other Drug Names	Main Known Action
BI 907828		MDM2 inhibitor

I/IIa

Advanced solid tumors

Phase 1/2a First in Human Study of BMS-986277 Administered Alone and in Combination With Nivolumab in Advanced Epithelial Tumors

New York

Drug(s) in Trial	Other Drug Names	Main Known Action
BMS-986277		Undisclosed mechanism
Nivolumab	BMS-936558, ONO-4538, MDX-1106, Anti-PD-1 human mab MDX-1106, Opdivo	Blocks PD-L1/2 inhibition of T cells

I/IIa

Advanced solid tumors

Phase 1/2a First-In-Human Study of BMS-986218 Monoclonal Antibody Alone and in Combination With Nivolumab in Advanced Solid Tumors

Massachusetts, New Jersey, New York, Pennsylvania

Drug(s) in Trial	Other Drug Names	Main Known Action
BMS-986218		Blocks CTLA-4 inhibition of T cells
Nivolumab	BMS-936558, ONO-4538, MDX-1106, Anti-PD-1 human mab MDX-1106, Opdivo	Blocks PD-L1/2 inhibition of T cells

I/IIa

Advanced solid tumors

Phase 1/2a First-In-Human Study of BMS-986207 Monoclonal Antibody Alone and in Combination With Nivolumab in Advanced Solid Tumors

New Jersey, New York, Pennsylvania, Utah

Drug(s) in Trial	Other Drug Names	Main Known Action
BMS-986207	anti-TIGIT monoclonal antibody BMS-986207	Blocks T cell binding to CD112 and CD155 to enable activation of CD226 signaling in NK and CD8 T cells
Nivolumab	BMS-936558, ONO-4538, MDX-1106, Anti-PD-1 human mab MDX-1106, Opdivo	Blocks PD-L1/2 inhibition of T cells

I/IIa

Advanced solid tumors

A Phase 1/2a Study of BMS-986179 Administered Alone and in Combination With Nivolumab (BMS-936558) in Subjects With Advanced Solid Tumors

Maryland, Massachusetts, New York, Pennsylvania, Tennessee, Texas

Drug(s) in Trial	Other Drug Names	Main Known Action
BMS-986179	anti-CD73 monoclonal antibody BMS-986179	Blocks Ecto-5-nucleotidase (CD73) inhibition of T cells
Nivolumab	BMS-936558, ONO-4538, MDX-1106, Anti-PD-1 human mab MDX-1106, Opdivo	Blocks PD-L1/2 inhibition of T cells

I/II

Advanced solid tumors

An Open-Label, Dose-Finding and Proof of Concept Study of the PD-L1 Probody™ Therapeutic , CX-072, as Monotherapy and in Combination With Yervoy (Ipilimumab) or With Zelboraf (Vemurafenib) in Subjects With Advanced or Recurrent Solid Tumors or Lymphomas

Arizona, California, Connecticut, Illinois, Indiana, Massachusetts, Michigan, New York, Ohio, Oregon, Tennessee, Texas, Utah, Virginia, Washington, Wisconsin

Drug(s) in Trial	Other Drug Names	Main Known Action
CX-072		Blocks PD-L1 inhibition of T cells
Ipilimumab	Anti-Cytotoxic T-Lymphocyte-Associated Antigen-4 Monoclonal Antibody, MDX-010, Yervoy	Blocks CTLA-4 inhibition of T cells
Vemurafenib	Zelboraf, PLX4032, RO5185426	BRAF kinase inhibitor

I/II

Recurrent, persistent or refractory high grade serous BRCA1/2-mutated ovarian cancer

A Phase I/II Evaluation of Olaparib in Combination With Durvalumab (Medi4736) and Tremelimumab in the Treatment of Recurrent Platinum Sensitive or Resistant or Refractory Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer in Patients Who Carry a BRCA1 or BRCA2 Mutation

New York

Drug(s) in Trial	Other Drug Names	Main Known Action
Durvalumab	Anti-B7H1 Monoclonal Antibody MEDI4736, MEDI4736, Imfinzi	Blocks PD-L1 inhibition of T cells
Olaparib	AZD2281, Lynparza	PARP inhibitor
Tremelimumab	anti-CTLA4 human monoclonal antibody CP-675,206, CP-675, CP-675,206, CP-675206, Ticilimumab	Blocks CTLA-4 inhibition of T cells

I/II

Platinum resistant or refractory ovarian cancer (with peritoneal disease)

A Phase 1/2 Dose Escalation Study With Expansion Cohorts to Investigate the Safety, Biologic and Anti-tumor Activity of ONCOS-102 in Combination With Durvalumab in Subjects With Advanced Peritoneal Malignancies

Florida, New York, Ohio, Virginia

Drug(s) in Trial	Other Drug Names	Main Known Action
Durvalumab	Anti-B7H1 Monoclonal Antibody MEDI4736, MEDI4736, Imfinzi	Blocks PD-L1 inhibition of T cells
ONCOS-102		Anti-tumor immune response

I/II

Platinum resistant ovarian cancer (at least 1 non-platinum therapy)

Anti-PD-1 Therapy in Combination With Platinum Chemotherapy for Platinum Resistant Ovarian, Fallopian Tube, and Primary Peritoneal Cancer

Washington

Drug(s) in Trial	Other Drug Names	Main Known Action
Carboplatin	Paraplatin, Novoplatinum	DNA damaging agent
Pembrolizumab	MK3475, SCH 900475, Lambrolizumab, Keytruda	Blocks PD-L1/2 inhibition of T cells

I/II

Advanced solid tumors

A Phase 1/2 Dose Escalation and Combination Cohort Study to Evaluate the Safety and Tolerability, Pharmacokinetics, and Efficacy of BMS-986226 Alone or in Combination With Nivolumab or Ipilimumab in Patients With Advanced Solid Tumors

Massachusetts, New Jersey, Pennsylvania, Tennessee

Drug(s) in Trial	Other Drug Names	Main Known Action
BMS-986226	anti-ICOS BMS-986226, anti-inducible T-cell co-stimulator BMS-986226	Stimulates ICOS to increase T cell activity and immune response
Ipilimumab	Anti-Cytotoxic T-Lymphocyte-Associated Antigen-4 Monoclonal Antibody, MDX-010, Yervoy	Blocks CTLA-4 inhibition of T cells
Nivolumab	BMS-936558, ONO-4538, MDX-1106, Anti-PD-1 human mab MDX-1106, Opdivo	Blocks PD-L1/2 inhibition of T cells

I/II

Advanced solid tumors

Phase 1/2 Study of CORT125134 in Combination With Nab-paclitaxel in Patients With Solid Tumors

Arizona, California, Illinois

Drug(s) in Trial	Other Drug Names	Main Known Action
nab-Paclitaxel	Paclitaxel Albumin-Stabilized Nanoparticle Formula, Abraxane, ABI-007	Microtubule stabilizer/mitotic inhibitor
Relacorilant	CORT125134	GR antagonist

I/II

Platinum resistant or refractory ovarian cancer

Phase I/II Trial of Intraperitoneal Administration of Adipose Tissue Derived Mesenchymal Stem Cells Infected With a NIS-Expressing Derivative Manufactured From a Genetically Engineered Strain of Measles Virus in Patients With Recurrent Ovarian Cancer

Minnesota

Drug(s) in Trial	Other Drug Names	Main Known Action
MV-NIS	oncolytic measles virus encoding thyroidal sodium iodide symporter	Induces immune response and tumor cell lysis

I/II

Advanced solid tumors

Phase 1/2 Multicenter Trial of ICOS Agonist Monoclonal Antibody (mAb) JTX-2011 Alone and in Combination With Nivolumab, Ipilimumab, or Pembrolizumab in Adult Subjects With Advanced and/or Refractory Solid Tumor Malignancies

California, Colorado, Connecticut, District of Columbia, Illinois, Massachusetts, Missouri, New Jersey, New York, Tennessee, Texas, Washington

Drug(s) in Trial	Other Drug Names	Main Known Action
Ipilimumab	Anti-Cytotoxic T-Lymphocyte-Associated Antigen-4 Monoclonal Antibody, MDX-010, Yervoy	Blocks CTLA-4 inhibition of T cells
JTX-2011	ICOS agonist monoclonal antibody	Stimulates ICOS to increase T cell activity and immune response
Nivolumab	BMS-936558, ONO-4538, MDX-1106, Anti-PD-1 human mab MDX-1106, Opdivo	Blocks PD-L1/2 inhibition of T cells
Pembrolizumab	MK3475, SCH 900475, Lambrolizumab, Keytruda	Blocks PD-L1/2 inhibition of T cells

I/II

Advanced solid tumors

A Phase 1/2 Study of Durvalumab and Monalizumab in Adult Subjects With Select Advanced Solid Tumors

Alabama, Arizona, California, Colorado, Florida, Illinois, Maryland, Massachusetts, Michigan, New Jersey, New York, Pennsylvania, Rhode Island, Tennessee, Texas, Utah, Washington

Drug(s) in Trial	Other Drug Names	Main Known Action
Cetuximab	Erbitux, Anti-EGFR Monoclonal Antibody, Chimeric MoAb C225	EGFR antagonist
Durvalumab	Anti-B7H1 Monoclonal Antibody MEDI4736, MEDI4736, Imfinzi	Blocks PD-L1 inhibition of T cells
Monalizumab	IPH2201, anti-NKG2A monoclonal antibody IPH2201	Blocks HLA-E inhibition of NKG2A+ NK and cytotoxic T-lymphocytes

I/II

Extrapulmonary small cell ovarian cancer

A Phase I/II Trial of Topotecan With VX970, an ATR Kinase Inhibitor in Small Cell Cancers

Maryland

Drug(s) in Trial	Other Drug Names	Main Known Action
Berzosertib	VX-970, M6620, VE-822, ATR kinase inhibitor VX-970	ATR kinase inhibitor
Topotecan	Hycamptamine, Hycamtin, TOPO	Topoisomerase I inhibitor

I/II

Advanced solid tumors

A Phase 1/2 Study of Oral LOXO-292 in Patients With Advanced Solid Tumors, Including RET Fusion-Positive Solid Tumors, Medullary Thyroid Cancer, and Other Tumors With RET Activation (LIBRETTO-001)

California, Colorado, Georgia, Illinois, Louisiana, Massachusetts, Michigan, New York, North Carolina, Ohio, Oregon, Pennsylvania, Tennessee, Texas, Utah, Wisconsin

Drug(s) in Trial	Other Drug Names	Main Known Action
LOXO-292	RET kinase inhibitor LOXO-292	RET-kinase inhibitor

I/II

Advanced HER2+ solid tumors

A Phase I-II, FIH Study of A166 in Locally Advanced/Metastatic Solid Tumors Expressing Human Epidermal Growth Factor Receptor 2 (HER2) or Are HER2 Amplified That Did Not Respond or Stopped Responding to Approved Therapies

Florida, Massachusetts, Michigan, New York, Oklahoma, Oregon, Texas, Virginia

Drug(s) in Trial	Other Drug Names	Main Known Action
A166	anti-HER2 antibody-drug conjugate A166	ADC: anti-HER2 + cytotoxic agent

I/II

Advanced solid tumors with high MSI or dMMR

A Phase I/II Open Label Study of the Safety and Efficacy of Apatinib Administered to Patients With Advanced Malignancies to Improve Sensitivity to Pembrolizumab in the Second- or Later-line Setting (APPEASE)

Utah

Drug(s) in Trial	Other Drug Names	Main Known Action
Apatinib	YN968D1, Aitan, ATAN, Rivoceranib	c-Met/VEGFR2 kinase inhibitor
Pembrolizumab	MK3475, SCH 900475, Lambrolizumab, Keytruda	Blocks PD-L1/2 inhibition of T cells

I/II

Platinum resistant or refractory ovarian cancer

A Phase 1/2 Study of REGN4018 Administered Alone or in Combination With Cemiplimab in Patients With Platinum-Resistant Ovarian Cancer

Massachusetts, New York, Ohio, Oklahoma, Tennessee

Drug(s) in Trial	Other Drug Names	Main Known Action
Cemiplimab	anti-PD-1 monoclonal antibody REGN2810, anti-PD-1 monoclonal antibody REGN2810	Blocks PD-L1/2 inhibition of T cells
REGN4018		Immune response against cancer expressing MUC16 (CA125)

I/II

Advanced solid tumors

A Phase 1/2 Study of Relatlimab (Anti-LAG-3 Monoclonal Antibody) Administered in Combination With Both Nivolumab (Anti-PD-1 Monoclonal Antibody) and BMS-986205 (IDO1 Inhibitor) or in Combination With Both Nivolumab and Ipilimumab (Anti-CTLA-4 Monoclonal Antibody) in Advanced Malignant Tumors

California, Colorado, Maryland, Missouri, Tennessee, Washington

Drug(s) in Trial	Other Drug Names	Main Known Action
BMS-986205		Inhibits IDO to stimulate immune response
Ipilimumab	Anti-Cytotoxic T-Lymphocyte-Associated Antigen-4 Monoclonal Antibody, MDX-010, Yervoy	Blocks CTLA-4 inhibition of T cells
Nivolumab	BMS-936558, ONO-4538, MDX-1106, Anti-PD-1 human mab MDX-1106, Opdivo	Blocks PD-L1/2 inhibition of T cells
Relatlimab	BMS986016, Anti-LAG-3 monoclonal antibody BMS-986016, Anti-LAG-3 monoclonal antibody BMS-986016	Blocks LAG-3 inhibition of T cells

I/II

Advanced solid tumors

A Phase 1/2, First-in-Human, Open-Label, Dose-Escalation Study of MGC018 (Anti-B7-H3 Antibody Drug Conjugate) Alone and in Combination With MGA012 (Anti-PD-1 Antibody) in Patients With Advanced Solid Tumors

Michigan, North Carolina, Virginia

Drug(s) in Trial	Other Drug Names	Main Known Action
MGA012	anti-PD-1 monoclonal antibody MGA012, INCMGA00012	Blocks PD-L1 inhibition of T cells
MGC018	A humanized anti-B7-H3 antibody conjugated to the vc- seco - DUocarmycin-hydroxyBenzamide-Azaindole (DUBA) 2 DNA alkylating payload	ADC: anti-B7-H3 + DNA alkylating agent (Duocarmycin)

I/II

Advanced solid tumors

Phase 1/2 Study of 9-ING-41, a Glycogen Synthase Kinase-3 Beta (GSK-3β) Inhibitor, as a Single Agent and Combined With Chemotherapy, in Patients With Refractory Hematologic Malignancies or Solid Tumors

California, Rhode Island

Drug(s) in Trial	Other Drug Names	Main Known Action
9-ING-41		Downregulates NF-kappaB
Carboplatin	Paraplatin, Novoplatinum	DNA damaging agent
Doxorubicin	14-Hydroxydaunomycin, Hydroxyl-Daunorubicin	Topoisomerase II inhibitor
Gemcitabine	Gemzar	Ribonucleotide reductase and DNA synthesis inhibitor
Lomustine	Gleostine, CCNU	DNA damaging agent
nab-Paclitaxel	Paclitaxel Albumin-Stabilized Nanoparticle Formula, Abraxane, ABI-007	Microtubule stabilizer/mitotic inhibitor
Paclitaxel	Anzatax, Asotax, Bristaxol, Praxel, Taxol, Taxol Konzentrat, TXL	Microtubule stabilizer/mitotic inhibitor

I/II

Advanced MSI-high solid tumors that relapsed following PD-1/L-1 checkpoint inhibitor therapy

A Phase I/II Open-label Study of EDP1503 Alone and in Combination With Pembrolizumab in Patients With Advanced Metastatic Colorectal Carcinoma, Triple-negative Breast Cancer, and Checkpoint Inhibitor Relapsed Tumors

Florida, Oklahoma, Tennessee

Drug(s) in Trial	Other Drug Names	Main Known Action
EDP1503	monoclonal microbial EDP1503
Pembrolizumab	MK3475, SCH 900475, Lambrolizumab, Keytruda	Blocks PD-L1/2 inhibition of T cells

I/II

Recurrent or persistent WT1+ ovarian cancer

A Phase 1/2 Study of Galinpepimut-S in Combination With Pembrolizumab (MK 3475) in Patients With Selected Advanced Cancers

California

Drug(s) in Trial	Other Drug Names	Main Known Action
Galinpepimut-S		Immune response against cancer expressing WT1
Pembrolizumab	MK3475, SCH 900475, Lambrolizumab, Keytruda	Blocks PD-L1/2 inhibition of T cells

I/II

Advanced solid tumors

Phase 1-2 Study Investigating Safety, Tolerability, Pharmacokinetics and Preliminary Antitumor Activity of Anti-TIM-3 Monoclonal Antibody BGB-A425 in Combination With Anti-PD-1 Monoclonal Antibody Tislelizumab in Patients With Advanced Solid Tumors

Colorado, Pennsylvania

Drug(s) in Trial	Other Drug Names	Main Known Action
BGB-A425		Blocks TIM-3 inhibition of T cells
Tislelizumab	anti-PD-1 monoclonal antibody BGB-A317	Blocks PD-L1/2 inhibition of T cells

I/II

Platinum resistant or refractory ovarian cancer (no prior therapies for resistant/refractory disease)

A Phase 1/2 Open-label, Multi-center, Safety, Preliminary Efficacy and Pharmacokinetic (PK) Study of Isatuximab (SAR650984) in Combination With Atezolizumab or Isatuximab Alone in Patients With Advanced Malignancies

California, Massachusetts, New Jersey, Pennsylvania, Texas

Drug(s) in Trial	Other Drug Names	Main Known Action
Atezolizumab	RG7446, MPDL3280A, Anti-PD-L1 Monoclonal Antibody MPDL3280A, Tecentriq	Blocks PD-L1 inhibition of T cells
Isatuximab	anti-CD38 monoclonal antibody SAR650984	Blocks CD38 and stimulates anti-tumor immune response

I/II

Advanced solid tumors

A Phase 1/2, Open-Label, Dose-Escalation, Safety and Tolerability Study of NC318 in Subjects With Advanced or Metastatic Solid Tumors

California, Connecticut, New Jersey, New York, Texas

Drug(s) in Trial	Other Drug Names	Main Known Action
NC318

I/II

Recurrent ovarian cancer with Ras pathway alterations or PARP inhibitor resistance

Evaluation of the Combination of Selumetinib and Olaparib in Endometrial, Ovarian and Other Solid Tumors With Ras Pathway Alterations, and Ovarian Tumors With PARP Resistance

Texas

Drug(s) in Trial	Other Drug Names	Main Known Action
Olaparib	AZD2281, Lynparza	PARP inhibitor
Selumetinib	AZD6244, ARRY-142886	MEK inhibitor

I/II

Advanced solid tumors

A Phase 1/2 Multicenter, Single-Arm, Open-Label, Dose-Escalation Study of Birinapant in Combination With Pembrolizumab (KEYTRUDA®) in Patients With Relapsed or Refractory Solid Tumors

California, Maryland, Pennsylvania, Texas

Drug(s) in Trial	Other Drug Names	Main Known Action
Birinapant	Smac Mimetic TL32711, TL32711	SMAC mimetic and IAP antagonist
Pembrolizumab	MK3475, SCH 900475, Lambrolizumab, Keytruda	Blocks PD-L1/2 inhibition of T cells

I/II

Advanced solid tumors

A Phase 1-2, Open-Label, Dose-Finding, Proof of Concept, First-in-Human Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of CX-2009 in Adults With Metastatic or Locally Advanced Unresectable Solid Tumors (PROCLAIM-CX-2009)

California, Connecticut, Illinois, Indiana, Massachusetts, Michigan, New York, Ohio, Oregon, Tennessee, Texas, Utah, Virginia, Washington, Wisconsin

Drug(s) in Trial	Other Drug Names	Main Known Action
CX-2009	anti-CD166 probody-drug conjugate CX-2009, PDC CX-2009, anti-CD166-DM4 CX-2009, ADC CX-2009	ADC: anti-CD166 + microtubule destabilizer (DM4)

I/II

Advanced solid tumors

A Phase 1/2 Study to Evaluate the Safety, Tolerability, and Efficacy of INCB001158 in Combination With Chemotherapy, in Subjects With Advanced or Metastatic Solid Tumors

Alabama, California, Georgia, Texas

Drug(s) in Trial	Other Drug Names	Main Known Action
Cisplatin	CACP, cis-DDP, cis-platinum, CDDP, Platinol, Abiplatin, Blastolem, Briplatin, Cisplatyl, Citoplatino, Citosin, Lederplatin, Metaplatin, Neoplatin, Placis, Platamine, Platiblastin, Platiblastin-S, Platinex, Platinol, Platiran, Platistin, Platosin	DNA damaging agent
Gemcitabine	Gemzar	Ribonucleotide reductase and DNA synthesis inhibitor
INCB001158	CB-1158, Arginase inhibitor	Arginase inhibitor
Paclitaxel	Anzatax, Asotax, Bristaxol, Praxel, Taxol, Taxol Konzentrat, TXL	Microtubule stabilizer/mitotic inhibitor

I/II

Advanced solid tumors

A Phase 1/2 Study to Investigate the Safety, Pharmacokinetics and Efficacy of EDO-S101, a First-in-Class Alkylating Histone Deacetylase Inhibition (HDACi) Fusion Molecule, in Patients With Advanced Solid Tumors

California, District of Columbia, Illinois, Michigan, New York, Texas

Drug(s) in Trial	Other Drug Names	Main Known Action
Tinostamustine	EDO-S101	HDAC inhibitor

I/II

Advanced solid tumors

A Phase 1/2 First-in-Human Study of BMS-986249 Alone and in Combination With Nivolumab in Advanced Solid Tumors

Colorado, Florida, Maryland, New Jersey, New York, Oregon, Pennsylvania, South Carolina, Texas, Virginia

Drug(s) in Trial	Other Drug Names	Main Known Action
BMS-986249	Probody of ipilumumab	Blocks CTLA-4 inhibition of T cells
Nivolumab	BMS-936558, ONO-4538, MDX-1106, Anti-PD-1 human mab MDX-1106, Opdivo	Blocks PD-L1/2 inhibition of T cells

I/II

Advanced solid tumors

A Phase 1/2, Open-label, Multicenter, Dose Escalation and Dose Expansion Study of NKTR-262 in Combination With NKTR-214 and in Combination With NKTR-214 Plus Nivolumab in Patients With Locally Advanced or Metastatic Solid Tumor Malignancies

Arizona, Connecticut, Florida, Georgia, New York, North Carolina, Oregon, Texas

Drug(s) in Trial	Other Drug Names	Main Known Action
Nivolumab	BMS-936558, ONO-4538, MDX-1106, Anti-PD-1 human mab MDX-1106, Opdivo	Blocks PD-L1/2 inhibition of T cells
NKTR-214		IL-2 receptor agonist
NKTR-262		TLR7/8 agonist and immune cell activator

I/II

Advanced solid tumors

First-in-human, Open-label, Dose-escalation Trial With Expansion Cohorts to Evaluate Safety of Axl-specific Antibody-drug Conjugate (HuMax®-AXL-ADC) in Patients With Solid Tumors

Arizona, California, Colorado, Connecticut, Florida, Georgia, Iowa, Massachusetts, Michigan, Minnesota, New York, North Carolina, Pennsylvania, Texas, Utah, Wisconsin

Drug(s) in Trial	Other Drug Names	Main Known Action
HuMax-AXL-ADC	anti-AXL monoclonal antibody-MMAE conjugate, anti-AXL/MMAE antibody-drug conjugate	ADC: anti-Axl + microtubule destabilizer (MMAE)

I/II

Advanced solid tumors

A Phase 1/2a Study of BMS-986253 in Combination With Nivolumab in Advanced Cancers

Colorado, Florida, Maryland, Michigan, Nevada, New Jersey, New York, Oklahoma, Oregon, Pennsylvania, South Carolina, Texas, Virginia

Drug(s) in Trial	Other Drug Names	Main Known Action
BMS-986253		IL-8 antagonist
Nivolumab	BMS-936558, ONO-4538, MDX-1106, Anti-PD-1 human mab MDX-1106, Opdivo	Blocks PD-L1/2 inhibition of T cells

I/II

Advanced solid tumors

A Phase I Study of the Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Properties of APG-1387 as A Single Agent or in Combination With Systemic Anti-Cancer Agents in Patients With Advanced Solid Tumors or Hematologic Malignancies

Texas

Drug(s) in Trial	Other Drug Names	Main Known Action
APG-138	SM-138	SMAC mimetic and IAP antagonist
Carboplatin	Paraplatin, Novoplatinum	DNA damaging agent
Paclitaxel	Anzatax, Asotax, Bristaxol, Praxel, Taxol, Taxol Konzentrat, TXL	Microtubule stabilizer/mitotic inhibitor
Pembrolizumab	MK3475, SCH 900475, Lambrolizumab, Keytruda	Blocks PD-L1/2 inhibition of T cells

I/II

Advanced solid tumors

A Phase 1/2 First-in-Human Study of BMS-986258 Alone and in Combination With Nivolumab in Advanced Malignant Tumors

California, Colorado, Pennsylvania, Tennessee

Drug(s) in Trial	Other Drug Names	Main Known Action
BMS-986258	anti-TIM3 antibody BMS-986258	Blocks TIM-3 inhibition of T cells
Nivolumab	BMS-936558, ONO-4538, MDX-1106, Anti-PD-1 human mab MDX-1106, Opdivo	Blocks PD-L1/2 inhibition of T cells

I/II

Advanced solid tumor (with at least one injectable tumor)

An Open-Label, Multicenter, Phase 1/2 Study of RP1 as a Single Agent and in Combination With PD1 Blockade in Patients With Solid Tumors

Miami

Drug(s) in Trial	Other Drug Names	Main Known Action
Nivolumab	BMS-936558, ONO-4538, MDX-1106, Anti-PD-1 human mab MDX-1106, Opdivo	Blocks PD-L1/2 inhibition of T cells
RP1		Induces immune response and tumor cell lysis

I/II

Advanced solid cancers

Poly-ICLC (Hiltonol®) Plus Anti-PD1 or Anti-PD-L1 in Unresectable Solid Cancers An Adaptive Phase I/II Clinical Pilot Study

Maryland, New York

Drug(s) in Trial	Other Drug Names	Main Known Action
Atezolizumab	RG7446, MPDL3280A, Anti-PD-L1 Monoclonal Antibody MPDL3280A, Tecentriq	Blocks PD-L1 inhibition of T cells
Durvalumab	Anti-B7H1 Monoclonal Antibody MEDI4736, MEDI4736, Imfinzi	Blocks PD-L1 inhibition of T cells
Nivolumab	BMS-936558, ONO-4538, MDX-1106, Anti-PD-1 human mab MDX-1106, Opdivo	Blocks PD-L1/2 inhibition of T cells
Pembrolizumab	MK3475, SCH 900475, Lambrolizumab, Keytruda	Blocks PD-L1/2 inhibition of T cells
poly ICLC	poly I:poly C with poly-1-lysine stabilizer, Polyinosinic-Polycytidylic Acid Stabilized with Polylysine and Carboxymethylcellulose, Hiltonol, poly-ICLC	Activates dendritic cells and induces interferon production

I/II

Advanced solid tumors

A Phase 1/2, Open-label, Multi-center Study of the Safety and Efficacy of KY1044 as Single Agent and in Combination With Anti-PD-L1 (Atezolizumab) in Adult Patients With Selected Advanced Malignancies

Connecticut, Florida, New York, Tennessee, Texas

Drug(s) in Trial	Other Drug Names	Main Known Action
Atezolizumab	RG7446, MPDL3280A, Anti-PD-L1 Monoclonal Antibody MPDL3280A, Tecentriq	Blocks PD-L1 inhibition of T cells
KY1044		Stimulates ICOS to increase T cell activity and immune response

I/Ib

Advanced solid tumors (inc expansion)

A Phase I/Ib, Open-label, Multi-center, Study of NZV930 as a Single Agent and in Combination With PDR001 and/or NIR178 in Patients With Advanced Malignancies.

Texas

Drug(s) in Trial	Other Drug Names	Main Known Action
NIR178	adenosine A2A receptor antagonist NIR178	Blocks adenosine A2A receptor inhibition of T cells
NZV930	SRF373	Blocks Ecto-5-nucleotidase (CD73) inhibition of T cells
Spartalizumab	anti-PD-1 monoclonal antibody PDR001	Blocks PD-L1/2 inhibition of T cells

I/Ib

Advanced solid tumors with MET, AXL, RET, TRK, DDR2, KDR, PDGFRA or KIT alterations (in expansion)

A Phase 1/1b Study of MGCD516 in Patients With Advanced Solid Tumor Malignancies

California, Colorado, Florida, Illinois, Louisiana, Maryland, Massachusetts, Michigan, Nebraska, New York, Ohio, Pennsylvania, South Carolina, Tennessee, Texas, Utah, Virginia, Washington, Wisconsin

Drug(s) in Trial	Other Drug Names	Main Known Action
Sitravatinib	MGCD516, multitargeted kinase inhibitor MGCD516	Multi-targeted RTK inhibitor

I/Ib

Advanced solid tumors (inc expansion--ATR, ATM, CHEK1/2, BRCA1/2, BAP1, BARD1, FANCA/C/D2/E, RAD50/51, PALB2, CDK12, POLE, POLD1, PRKDC, ERCC2, POLQ, MRE11A, NBN mutations or FANCA/C/D2/E or EMSY amplification)

Phase I/Ib Study of Nivolumab and Veliparib in Patients With Advanced Solid Tumors and Lymphoma With and Without Alterations in Selected DNA Repair Genes

Illinois

Drug(s) in Trial	Other Drug Names	Main Known Action
Nivolumab	BMS-936558, ONO-4538, MDX-1106, Anti-PD-1 human mab MDX-1106, Opdivo	Blocks PD-L1/2 inhibition of T cells
Veliparib	ABT-888	PARP inhibitor

I/Ib

Advanced solid tumors (inc expansion)

A Phase I/Ib Open-label, Multi-center, Dose Escalation Study of GWN323 (Anti-GITR) as a Single Agent and in Combination With PDR001 (Anti-PD-1) in Patients With Advanced Solid Tumors and Lymphomas

New York, Texas

Drug(s) in Trial	Other Drug Names	Main Known Action
GWN323	anti-GITR monoclonal antibody GWN 323	GITR (glucocorticoid-induced TNFR) agonist
Spartalizumab	anti-PD-1 monoclonal antibody PDR001	Blocks PD-L1/2 inhibition of T cells

I

Advanced solid tumors (inc expansion)

A Phase 1, Dose Escalation Study of ALX148 in Patients With Advanced Solid Tumors and Lymphoma

Colorado, Connecticut, Massachusetts, Michigan, Washington

Drug(s) in Trial	Other Drug Names	Main Known Action
ALX148		Blocks CD47 signaling to stimulate immune response and tumor cell phagocytosis
Atezolizumab	RG7446, MPDL3280A, Anti-PD-L1 Monoclonal Antibody MPDL3280A, Tecentriq	Blocks PD-L1 inhibition of T cells
Trastuzumab	Herceptin, Anti-erbB2 Monoclonal Antibody, HER2 Monoclonal Antibody	HER2 antagonist

I

Advanced solid tumors (inc ovarian expansion)

A Multi-Center, Phase 1, Open-Label, Dose-Escalation Study of ABBV-428, an Immunotherapy in Subjects With Advanced Solid Tumors

Arizona, California, Illinois, Pennsylvania, South Carolina, Texas

Drug(s) in Trial	Other Drug Names	Main Known Action
ABBV-428		Stimulates CD40 to increase/activate antigen-presenting cells and enhance immune response

I

Advanced solid tumors

A Phase I/II, Open-label, Multi-center Study of the Safety and Efficacy of BLZ945 as Single Agent and in Combination With PDR001 in Adults Patients With Advanced Solid Tumors

Tennessee, Texas

Drug(s) in Trial	Other Drug Names	Main Known Action
BLZ945	CSF-1R inhibitor BLZ945	CSF1R antagonist and tumor-associated macrophage inhibitor
Spartalizumab	anti-PD-1 monoclonal antibody PDR001	Blocks PD-L1/2 inhibition of T cells

I

Advanced solid tumors (inc expansion)

Phase I, Multicenter, Open-label, Clinical and Pharmacokinetic Study of PM01183 in Combination With Irinotecan in Pretreated Patients With Selected Advanced Solid Tumors

Massachusetts

Drug(s) in Trial	Other Drug Names	Main Known Action
Irinotecan	Camptosar, Campto, Campothecin-11	Topoisomerase I inhibitor
Lurbinectedin	PM01183

I

Advanced solid tumors

NY-ESO-1 TCR Engineered Adoptive Cell Transfer Therapy With CTLA4 Blockade

California

Drug(s) in Trial	Other Drug Names	Main Known Action
Cyclophosphamide	Ciclofosfamida, Ciclofosfamide, Claphene, CP monohydrate, CPM, Cyclophospham, Cyclophosphamid monohydrate, Cyclophosphamidum, Cyclophosphan, Cyclophosphanum, Cytophosphane, Mitoxan, Syklofosfamid, Zytoxan, Clafen, Cytoxan, Neosar, Carloxan, Cicloxal, Cycloblastin, Cycloblastine, CYCLO-cell, Cyclostin, Cyclostine, Cytophosphan, Endoxan, Endoxana, Enduxan, Fosfaseron, Genoxal, Ledoxina, Procytox, Sendoxan	DNA damaging agent
Ipilimumab	Anti-Cytotoxic T-Lymphocyte-Associated Antigen-4 Monoclonal Antibody, MDX-010, Yervoy	Blocks CTLA-4 inhibition of T cells
NY-ESO-1 reactive TCR retroviral vector transduced autologous PBL	anti-NY-ESO-1 TCR gene-engineered lymphocytes	Immune response against cancer expressing NY-ESO-1
NY-ESO-1(157-165) peptide-pulsed autologous dendritic cell vaccine		Immune response against cancer expressing NY-ESO-1

I

MUC16+ recurrent high grade serous ovarian cancer (> 2 prior therapies)

A Phase I Clinical Trial of Cyclophosphamide Followed by Intravenous and Intraperitoneal Infusion of Autologous T Cells Genetically Engineered to Secrete IL-12 and to Target the MUC16ecto Antigen in Patients With Recurrent MUC16ecto+ Solid Tumors

New York

Drug(s) in Trial	Other Drug Names	Main Known Action
4H11-28z/fIL-12/EFGRt-expressing autologous T lymphocytes	4H11-28z/fIL-12/EFGRt+ genetically-modified T cells, autologous MUC16ecto-targeting EGFR-secreting T lymphocytes	Immune response against cancer expressing CA125
Cyclophosphamide	Ciclofosfamida, Ciclofosfamide, Claphene, CP monohydrate, CPM, Cyclophospham, Cyclophosphamid monohydrate, Cyclophosphamidum, Cyclophosphan, Cyclophosphanum, Cytophosphane, Mitoxan, Syklofosfamid, Zytoxan, Clafen, Cytoxan, Neosar, Carloxan, Cicloxal, Cycloblastin, Cycloblastine, CYCLO-cell, Cyclostin, Cyclostine, Cytophosphan, Endoxan, Endoxana, Enduxan, Fosfaseron, Genoxal, Ledoxina, Procytox, Sendoxan	DNA damaging agent
Fludarabine	Fludara Oral, 2-F-ara-AMP, Beneflur	DNA synthesis inhibitor

I

Advanced solid tumors (in ovarian expansion)

An Open-Label Study of the Safety, Tolerability, and Pharmacokinetic/Pharmacodynamic Profile of VX-803/M4344 as a Single Agent and in Combination With Cytotoxic Chemotherapy in Participants With Advanced Solid Tumors

Massachusetts, Tennessee

Drug(s) in Trial	Other Drug Names	Main Known Action
Carboplatin	Paraplatin, Novoplatinum	DNA damaging agent
Cisplatin	CACP, cis-DDP, cis-platinum, CDDP, Platinol, Abiplatin, Blastolem, Briplatin, Cisplatyl, Citoplatino, Citosin, Lederplatin, Metaplatin, Neoplatin, Placis, Platamine, Platiblastin, Platiblastin-S, Platinex, Platinol, Platiran, Platistin, Platosin	DNA damaging agent
Gemcitabine	Gemzar	Ribonucleotide reductase and DNA synthesis inhibitor
M4344	VX-803	ATR kinase inhibitor

I

Advanced solid tumors (in expansion)

A Phase I, Open-Label, Non-Randomized, Dose-Escalating Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Study of TAS-119 in Patients With Advanced Solid Tumors

Ohio

Drug(s) in Trial	Other Drug Names	Main Known Action
Paclitaxel	Anzatax, Asotax, Bristaxol, Praxel, Taxol, Taxol Konzentrat, TXL	Microtubule stabilizer/mitotic inhibitor
TAS-119	Aurora A kinase inhibitor TAS-119, TAS-2104	Aurora A kinase inhibitor

I

Advanced solid tumors

A Phase I, Dose-Escalation, Safety and Tolerability Study of COH29 in Patients With Solid Tumors Refractory to Standard Therapy or for Which No Standard Therapy Exists

California

Drug(s) in Trial	Other Drug Names	Main Known Action
COH29	RNR inhibitor COH29, ribonucleotide reductase holoenzyme inhibitor COH29	Ribonucleotide reductase inhibitor

I

Advanced solid tumors with EGFR mutation/amplification, HER2 mutation/amplification, HER3/4 mutation or KRAS mutation (inc expansion)

Phase I Study of the Pan-ERBB Inhibitor Neratinib Given in Combination With Everolimus, Palbociclib or Trametinib in Advanced Cancer Subjects With EGFR Mutation/Amplification, HER2 Mutation/Amplification, HER3/4 Mutation or KRAS Mutation

Texas

Drug(s) in Trial	Other Drug Names	Main Known Action
Everolimus	Zortress, RAD001, Certican, Afinitor	mTOR inhibitor
Neratinib	HKI-272, PD272	EGFR, HER2, HER4 kinase inhibitor
Palbociclib	PD-0332991, PD0332991, Ibrance	CDK4/6 inhibitor
Trametinib	Mekinist, MEK Inhibitor GSK1120212, JTP-74057, GSK1120212, TMT212	MEK1/2 inhibitor

I

Advanced solid tumors

A Multicenter, Phase 1, Open-Label, Dose-Escalation Study of ABBV-927 and ABBV-181, an Immunotherapy, in Subjects With Advanced Solid Tumors

California, Illinois, Massachusetts, North Carolina, Tennessee, Texas, Virginia

Drug(s) in Trial	Other Drug Names	Main Known Action
ABBV-181	anti-PD1 monoclonal antibody ABBV-181	Blocks PD-L1 inhibition of T cells
ABBV-927	anti-CD40 agonist monoclonal antibody ABBV-927	Stimulates CD40 to increase/activate antigen-presenting cells and enhance immune response

I

Advanced solid tumors (inc expansion)

A Phase-1 Study Evaluating the Safety, Pharmacology and Preliminary Activity of MM-310 in Patients With Solid Tumors

Arizona, California, Minnesota, New York, North Carolina

Drug(s) in Trial	Other Drug Names	Main Known Action
MM-310		EphA2-targeted tubulin inhibitor

I

Advanced solid tumors (inc expansion)

Phase I Study of the CDK4/6 Inhibitor Palbociclib (PD-0332991) in Combination With the PI3K/mTOR Inhibitor Gedatolisib (PF-05212384) for Patients With Advanced Squamous Cell Lung, Pancreatic, Head & Neck and Other Solid Tumors

Massachusetts

Drug(s) in Trial	Other Drug Names	Main Known Action
Gedatolisib	PKI-587, PF-05212384, dual PI3 kinase/mTOR inhibitor PKI-587	PI3K/mTOR inhibitor
Palbociclib	PD-0332991, PD0332991, Ibrance	CDK4/6 inhibitor

I

Platinum resistant or refractory CD44+ ovarian cancer (in expansion)

An Open-label Phase 1 Trial of the Safety and Efficacy of Daily Subcutaneous SPL-108 Injections When Used In Combination With Paclitaxel In Patients With Platinum-resistant, CD44+, Advanced Ovarian Epithelial Cancer

New Jersey, New York

Drug(s) in Trial	Other Drug Names	Main Known Action
Paclitaxel	Anzatax, Asotax, Bristaxol, Praxel, Taxol, Taxol Konzentrat, TXL	Microtubule stabilizer/mitotic inhibitor
SPL-108	CD44 targeted agent SPL-108	CD44 inhibitor

I

Advanced solid tumors ( with palliative radiation recommended)

A Pilot Study to Assess the Combination of High-Dose Conformal Radiation Therapy (HDCRT) and Pembrolizumab in Modulating Local and Systemic T-cell Responses in Advanced Malignancies

Virginia

Drug(s) in Trial	Other Drug Names	Main Known Action
Pembrolizumab	MK3475, SCH 900475, Lambrolizumab, Keytruda	Blocks PD-L1/2 inhibition of T cells

I

Advanced solid tumors with BRAF, KRAS, NRAS or HRAS mutations

A Phase 1 First-in-Human Study of KO-947 in Locally Advanced Unresectable or Metastatic, Relapsed and/or Refractory Non-Hematological Malignancies

Minnesota, Pennsylvania

Drug(s) in Trial	Other Drug Names	Main Known Action
KO-947		ERK inhibitor

I

Advanced solid tumors

A Multicenter, Phase 1, Open-Label, Dose-Escalation Study of the Safety, Tolerability and Pharmacokinetics of ABBV-368 as a Single Agent and Combination in Subjects With Locally Advanced or Metastatic Solid Tumors

California, Connecticut, North Carolina, South Carolina, Texas, Virginia

Drug(s) in Trial	Other Drug Names	Main Known Action
ABBV-368		Stimulates OX40 to increase T cell activation and immune response

I

Advanced solid tumors

Phase 1 Combination Study of Prexasertib (LY2606368), CHK1 Inhibitor, and Olaparib, PARP Inhibitor, in Patients With Advanced Solid Tumors

Massachusetts

Drug(s) in Trial	Other Drug Names	Main Known Action
Olaparib	AZD2281, Lynparza	PARP inhibitor
Prexasertib	checkpoint kinase 1 inhibitor LY2606368, LY2606368	Chk1/2 inhibitor

I

Advanced solid tumors (in ovarian expansion)

A Phase 1 Dose-escalation Study of Radio- Labeled Antibody, FF-21101(90Y) for the Treatment of Advanced Cancer

Texas

Drug(s) in Trial	Other Drug Names	Main Known Action
FF-21101(90Y)	yttrium Y 90 anti-CDH3 monoclonal antibody FF-21101	Radioimmunotherapy: anti-CDH3 + Y90

I

Advanced solid tumors (in expansion)

A Phase I Dose-Escalation Study of Onc201 Administered Every One or Three Weeks in Advanced Solid Tumors and Multiple Myeloma

Pennsylvania

Drug(s) in Trial	Other Drug Names	Main Known Action
ONC201	AKT/ERK inhibitor ONC201, TIC10	AKT and ERK kinase inhibitor

I

Advanced solid tumors (inc expansion)

Phase I Study of TAK-228 (MLN0128) in Combination With Metformin in Patients With Advanced Cancers

Texas

Drug(s) in Trial	Other Drug Names	Main Known Action
Metformin	Fortamet, Glucophage, Glumetza, Riomet	AMP-activated protein kinase (AMPK) activator
Sapanisertib	TAK-228, MLN0128, TORC1/2 Inhibitor MLN0128, TORC1/2 Inhibitor INK128, INK128	TORC1/2 kinase inhibitor

I

Recurrent or refractory ovarian cancer

A Phase I Open Label Clinical Trial Evaluating the Safety and Efficacy of Adoptive Transfer of NY-ESO-1 TCR Engineered Autologous T Cells in Combination With Decitabine in Patients With Recurrent or Treatment Refractory Ovarian Cancer

New York

Drug(s) in Trial	Other Drug Names	Main Known Action
Cyclophosphamide	Ciclofosfamida, Ciclofosfamide, Claphene, CP monohydrate, CPM, Cyclophospham, Cyclophosphamid monohydrate, Cyclophosphamidum, Cyclophosphan, Cyclophosphanum, Cytophosphane, Mitoxan, Syklofosfamid, Zytoxan, Clafen, Cytoxan, Neosar, Carloxan, Cicloxal, Cycloblastin, Cycloblastine, CYCLO-cell, Cyclostin, Cyclostine, Cytophosphan, Endoxan, Endoxana, Enduxan, Fosfaseron, Genoxal, Ledoxina, Procytox, Sendoxan	DNA damaging agent
Decitabine	Dacogen, dezocitidine, deoxyazacytidine, 5-aza-dCyd	DNA methylation inhibitor
Genetically Engineered NY-ESO-1-specific T Lymphocytes		Immune response against cancer expressing NY-ESO-1

I

Platinum resistant FRalpha+ advanced ovarian cancer (< 5 prior therapies)

A Phase I Dose-Escalation Safety and Tolerability Study of Mirvetuximab Soravtansine (IMGN853) and Gemcitabine in Patients With FRa-positive Recurrent Ovarian, Primary Peritoneal, Fallopian Tube, Endometrial Cancer, or Triple Negative Breast Cancer (TNBC)

California

Drug(s) in Trial	Other Drug Names	Main Known Action
Gemcitabine	Gemzar	Ribonucleotide reductase and DNA synthesis inhibitor
Mirvetuximab Soravtansine	M9346A-sulfo-SPDB-DM4, IMGN853, Anti-FOLR1-mab Maytansinoid Conjugate	ADC: anti-FOLR1 + microtubule destabilizer (DM4)

I

Advanced solid tumors

A Phase 1 Study of MK-3475 (Pembrolizumab) in Combination With Recombinant Interleukin-12 in Patients With Solid Tumors

California, Colorado, Connecticut, Florida, Iowa, Maryland, Massachusetts, Missouri, New Jersey, North Carolina, Ohio, Pennsylvania, Virginia

Drug(s) in Trial	Other Drug Names	Main Known Action
IL-12	cytotoxic lymphocyte maturation factor interleukin-12, Ro 24-7472, recombinant interleukin-12, natural killer cell stimulatory factor NM-IL-12	IL-12 receptor agonist
Pembrolizumab	MK3475, SCH 900475, Lambrolizumab, Keytruda	Blocks PD-L1/2 inhibition of T cells

I

Advanced solid tumors

A Phase Ib Study to Evaluate the Safety and Tolerability of MK-8353 in Combination With Pembrolizumab in Patients With Advanced Malignancies

Michigan, Tennessee

Drug(s) in Trial	Other Drug Names	Main Known Action
MK-8353	ERK1 inhibitor MK-8353	ERK inhibitor
Pembrolizumab	MK3475, SCH 900475, Lambrolizumab, Keytruda	Blocks PD-L1/2 inhibition of T cells

I

Advanced solid tumors

An Open-label, Phase I Dose Escalation Trial of Methionine Aminopeptidase 2 Inhibitor M8891 in Subjects With Advanced Solid Tumors

Connecticut, Indiana, Maryland, Michigan, New Jersey

Drug(s) in Trial	Other Drug Names	Main Known Action
M8891	Methionine Aminopeptidase 2 Inhibitor M8891	Angiogenesis inhibitor

I

Advanced solid tumors

A Phase 1/1b First-in-Human Dose Escalation and Expansion Study for the Evaluation of Safety, Pharmacokinetics, Pharmacodynamics and Anti-tumor Activity of SAR439459 Administered Intravenously as Monotherapy and in Combination With REGN2810 in Adult Patients With Advanced Solid Tumors

Kansas, Massachusetts, Tennessee, Texas

Drug(s) in Trial	Other Drug Names	Main Known Action
Cemiplimab	anti-PD-1 monoclonal antibody REGN2810, anti-PD-1 monoclonal antibody REGN2810	Blocks PD-L1/2 inhibition of T cells
SAR439459	anti-TGF-beta monoclonal antibody SAR-439459	TGFbeta antagonist

I

Advanced ovarian cancer (no prior PARPi)

A Phase 1 Evaluation of the Safety and Tolerability of Niraparib in Combination With Everolimus in Advanced Ovarian and Breast Cancer

South Dakota

Drug(s) in Trial	Other Drug Names	Main Known Action
Everolimus	Zortress, RAD001, Certican, Afinitor	mTOR inhibitor
Niraparib	MK4827, Zejula	PARP inhibitor

I

Advanced solid tumors

A Phase I Open-Label Pharmacokinetics and Safety Study of Talazoparib (MDV3800) in Patients With Advanced Solid Tumors and Normal or Varying Degrees of Hepatic Impairment

California, Florida, Massachusetts, Texas

Drug(s) in Trial	Other Drug Names	Main Known Action
Talazoparib	Talazoparib Tosylate, BMN-673, MDV3800	PARP inhibitor

I

Advanced solid tumors

A Phase 1/2 Study Exploring the Safety, Tolerability, and Efficacy of INCAGN01876 in Combination With Immune Therapies in Subjects With Advanced or Metastatic Malignancies

California, Florida, Michigan, Missouri, New Jersey, New York, North Carolina, Oklahoma, Oregon, Pennsylvania, Tennessee, Texas, Washington

Drug(s) in Trial	Other Drug Names	Main Known Action
INCAGN01876	anti-GITR agonistic monoclonal antibody INCAGN01876	GITR (glucocorticoid-induced TNFR) agonist
Ipilimumab	Anti-Cytotoxic T-Lymphocyte-Associated Antigen-4 Monoclonal Antibody, MDX-010, Yervoy	Blocks CTLA-4 inhibition of T cells
Nivolumab	BMS-936558, ONO-4538, MDX-1106, Anti-PD-1 human mab MDX-1106, Opdivo	Blocks PD-L1/2 inhibition of T cells

I

Advanced solid tumors (inc ovarian expansion)

A Phase I, Multicenter Dose-Escalation Study to Assess the Tolerability, Pharmacokinetics and Preliminary Anti-tumor Activity of AZD5153 in Patients With Relapsed/Refractory Malignant Solid Tumors, Including Lymphomas

Florida, Oklahoma, Tennessee

Drug(s) in Trial	Other Drug Names	Main Known Action
AZD5153		BRD4 inhibitor
Olaparib	AZD2281, Lynparza	PARP inhibitor

I

Advanced solid tumors with PTEN loss/mutations or PIK3CB mutation/amplification (in expansion)

A Phase I, Open-label, Multicentre Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Preliminary Anti-tumour Activity of AZD8186 in Patients With Advanced Castration-resistant Prostate Cancer (CRPC), Squamous Non-Small Cell Lung Cancer (sqNSCLC), Triple Negative Breast Cancer (TNBC) and Patients With Known PTEN-deficient/Mutated or PIK3CB Mutated/ Amplified Advanced Solid Malignancies as Monotherapy and in Combination With Abiraterone Acetate or AZD2014

Massachusetts, Michigan, New York, Washington, Wisconsin

Drug(s) in Trial	Other Drug Names	Main Known Action
AZD8186	PI3Kbeta inhibitor AZD8186	AKT/PI3K/mTOR inhibitor

I

Advanced solid tumors

A Phase 1 Open-label, Multicenter Study of MK-2118 Administered by Intratumoral Injection as Monotherapy and in Combination With Pembrolizumab or by Subcutaneous Injection in Combination With Pembrolizumab for Patients With Advanced/Metastatic Solid Tumors or Lymphomas

California, Illinois, New York, Texas

Drug(s) in Trial	Other Drug Names	Main Known Action
MK-2118		Immune cell stimulation
Pembrolizumab	MK3475, SCH 900475, Lambrolizumab, Keytruda	Blocks PD-L1/2 inhibition of T cells

I

Advanced solid tumors

A Phase I Study to Evaluate the Safety of Trigriluzole (FC-4157/BHV-4157) in Combination With PD-1 Blocking Antibodies

New Jersey

Drug(s) in Trial	Other Drug Names	Main Known Action
Nivolumab	BMS-936558, ONO-4538, MDX-1106, Anti-PD-1 human mab MDX-1106, Opdivo	Blocks PD-L1/2 inhibition of T cells
Pembrolizumab	MK3475, SCH 900475, Lambrolizumab, Keytruda	Blocks PD-L1/2 inhibition of T cells
Trigriluzole	BHV-4157, FC-4157	Glutamate antagonist

I

Advanced solid tumors with PTEN or PIK3CB mutations (inc expansion)

A Phase I Study of AZD8186 in Combination With Docetaxel in Patients With PTEN Mutated or PIK3CB Mutated Advanced Solid Tumors, Potentially Amenable to Docetaxel

Colorado, Maryland, New York, Texas

Drug(s) in Trial	Other Drug Names	Main Known Action
AZD8186	PI3Kbeta inhibitor AZD8186	AKT/PI3K/mTOR inhibitor
Docetaxel	Taxotere	Microtubule stabilizer/mitotic inhibitor

I

Advanced solid tumors (inc expansion)

A Phase 1 With Expansion Cohort, Open-Label, Dose Escalation Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of Intravenously Infused IT-141 in Subjects With Recurrent or Refractory Solid Tumors

Texas, Washington

Drug(s) in Trial	Other Drug Names	Main Known Action
IT-141		Topoisomerase I inhibitor

I

Advanced solid tumors

Phase I Study of the Non-receptor Kinase Inhibitor Bosutinib in Combination With Pemetrexed in Patients With Selected Metastatic Solid Tumors

Ohio

Drug(s) in Trial	Other Drug Names	Main Known Action
Bosutinib	Bosulif, SKI-606	Abl and src family kinase inhibitor
Pemetrexed	Pemetrexed disodium, Alimta	DHFR and Thymidylate synthase inhibitor

I

Advanced solid tumors (in expansion)

Multi-center, Phase 1, Open-Label Study of DCC-3014 to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics in Patients With Advanced Malignancies

Colorado, Oregon, Tennessee

Drug(s) in Trial	Other Drug Names	Main Known Action
DCC-3014		CSF1R kinase inhibitor

I

Advanced solid tumors (inc expansion)

A Phase 1 First Time in Human Study to Evaluate the Safety, Pharmacokinetics and Immunogenicity of MEDI5083 Alone and in Combination With Durvalumab in Selected Advanced Solid Tumors

California, New Jersey, Rhode Island, Tennessee, Utah

Drug(s) in Trial	Other Drug Names	Main Known Action
Durvalumab	Anti-B7H1 Monoclonal Antibody MEDI4736, MEDI4736, Imfinzi	Blocks PD-L1 inhibition of T cells
MEDI5083	CD40L-Fc fusion protein MEDI 5083	Stimulates CD40 to increase/activate antigen-presenting cells and enhance immune response

I

Advanced solid tumors

A Phase 1 Study of NLG802 for Adult Patients With Recurrent Advanced Solid Tumors

Florida, New Mexico

Drug(s) in Trial	Other Drug Names	Main Known Action
NLG802	Indoleamine 2,3-Dioxygenase (IDO) Inhibitor	Inhibits IDO to stimulate immune response

I

Advanced solid tumors

A Phase I Study of the Safety, Pharmacokinetic and Pharmacodynamic Properties of Orally Administered APG-115 in Patients With Advanced Solid Tumors or Lymphomas

Michigan, Texas

Drug(s) in Trial	Other Drug Names	Main Known Action
APG-115	p53-HDM2 protein-protein interaction inhibitor APG-115, MDM2-p53 inhibitor APG-115	MDM2 inhibitor

I

Recurrent, persistent or refractory ovarian cancer (in expansion)

Phase I Study of Intra-peritoneal Cantrixil in Patients With Persistent or Recurrent Ovarian Cancer, Fallopian Tube Cancer or Primary Peritoneal Cancer.

Oklahoma, Rhode Island, Texas

Drug(s) in Trial	Other Drug Names	Main Known Action
Cantrixil	TRX-E-002-1 in 20% SBECD, TRX-E-002-1	Tubulin polymerization inhibitor

I

Advanced solid tumors

A Phase 1/2a, Open-label, Multicenter Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Anti-tumor Activity of PEN-866 in Patients With Advanced Solid Malignancies

Colorado, Maryland, Tennessee

Drug(s) in Trial	Other Drug Names	Main Known Action
PEN-866	HDC SN-38, STA-12-8666	Hsp90-targeted topoisomerase I inhibitor

I

Advanced solid tumors (in expansion)

A Phase 1 Study of TRX518 Monotherapy and TRX518 in Combination With Gemcitabine, Pembrolizumab, or Nivolumab in Adults With Advanced Solid Tumors

Illinois, New Mexico, Ohio, Pennsylvania, Tennessee

Drug(s) in Trial	Other Drug Names	Main Known Action
Gemcitabine	Gemzar	Ribonucleotide reductase and DNA synthesis inhibitor
Pembrolizumab	MK3475, SCH 900475, Lambrolizumab, Keytruda	Blocks PD-L1/2 inhibition of T cells
TRX518	anti-huGITR monoclonal antibody TRX518, anti-huGITR mAb TRX518, anti-huGITR MoAb TRX518	GITR (glucocorticoid-induced TNFR) agonist

I

Advanced solid tumors (in expansion)

Part A: A First-in-Human Single Ascending Dose Study of TRX518 in Subjects With Unresectable Stage III or Stage IV Malignant Melanoma or Other Solid Tumor Malignancies Part B: A Dose-Escalation Study of Multi-dose TRX518 Monotherapy Part C: An Expansion Cohort of Multi-dose TRX518 Monotherapy at the Maximum Tolerated Dose

New York

Drug(s) in Trial	Other Drug Names	Main Known Action
TRX518	anti-huGITR monoclonal antibody TRX518, anti-huGITR mAb TRX518, anti-huGITR MoAb TRX518	GITR (glucocorticoid-induced TNFR) agonist

I

Advanced solid tumors (amenable to radiation treatment)

A Phase I, Open-label, Uncontrolled, Multicenter, Dose-escalation Study of M3541 in Combination With Palliative Radiotherapy in Subjects With Solid Tumors

Indiana, Missouri, New Jersey, Pennsylvania, Tennessee

Drug(s) in Trial	Other Drug Names	Main Known Action
M3541	ATM inhibitor M 3541	ATM kinase inhibitor

I

Advanced solid tumors (inc expansion)

Phase I Study of CDK4/6 Inhibitor Ribociclib (LEE011) Combined With Gemcitabine in Patients With Advanced Solid Tumors

Arizona, Florida, Minnesota

Drug(s) in Trial	Other Drug Names	Main Known Action
Gemcitabine	Gemzar	Ribonucleotide reductase and DNA synthesis inhibitor
Ribociclib	Kisqali, CDK4/6 Inhibitor LEE011, LEE011, Kisqali	CDK4/6 inhibitor

I

Advanced ER+ and HER2+ solid tumors (in expansion)

Combination Treatment With Everolimus, Letrozole and Trastuzumab in Hormone Receptor and HER2/Neu-positive Patients With Advanced Metastatic Breast Cancer and Other Solid Tumors: Evaluating Synergy and Overcoming Resistance

Texas

Drug(s) in Trial	Other Drug Names	Main Known Action
Everolimus	Zortress, RAD001, Certican, Afinitor	mTOR inhibitor
Letrozole	Femara	Aromatase inhibitor
Trastuzumab	Herceptin, Anti-erbB2 Monoclonal Antibody, HER2 Monoclonal Antibody	HER2 antagonist

I

Advanced solid tumors

Phase 1 Safety, Pharmacokinetic And Pharmacodynamic Study Of PF-02341066, A c-Met/HGFR Selective Tyrosine Kinase Inhibitor, Administered Orally To Patients With Advanced Cancer

California, Colorado, Massachusetts, Michigan, New York, North Carolina, Ohio, Pennsylvania, Vermont

Drug(s) in Trial	Other Drug Names	Main Known Action
Crizotinib	c-met/HGFR tyrosine kinase inhibitor PF-02341066, PF-02341066, Xalkori	c-Met and ALK kinase inhibitor

I

Advanced solid tumors that are TP53 WT (in expansion)

A Phase 1 Multiple Ascending Dose Study of DS-3032b, an Oral MDM2 Inhibitor, in Subjects With Advanced Solid Tumors or Lymphomas

Michigan, New York, Texas

Drug(s) in Trial	Other Drug Names	Main Known Action
DS-3032b		MDM2 inhibitor

I

Advanced solid tumors including those with BRCA mutations (in expansion)

Phase 1 Trial of ABT-888 and SCH727965 in Patients With Advanced Solid Tumors

Massachusetts

Drug(s) in Trial	Other Drug Names	Main Known Action
Dinaciclib	CDK inhibitor SCH 727965, SCH 727965	CDK1, 2, 5, 9 inhibitor
Veliparib	ABT-888	PARP inhibitor

I

Advanced solid tumors

A Phase 1 Trial of Vandetanib (a Multi-kinase Inhibitor of EGFR, VEGFR and RET Inhibitor) in Combination With Everolimus (an mTOR Inhibitor) in Advanced Cancer

Texas

Drug(s) in Trial	Other Drug Names	Main Known Action
Everolimus	Zortress, RAD001, Certican, Afinitor	mTOR inhibitor
Vandetanib	AZD6474, Zactima, ZD6474	VEGFR, EGFR, and RET kinase inhibitor

I

Advanced solid tumors dependent on Wnt ligands (e.g., RNF43 mutations, RSPO fusion); in expansion

A Phase I, Open-label, Dose Escalation Study of Oral LGK974 in Patients With Malignancies Dependent on Wnt Ligands

California, Maryland, Massachusetts, Michigan, Texas

Drug(s) in Trial	Other Drug Names	Main Known Action
LGK974	PORCN inhibitor LGK974, porcupine inhibitor WNT974	WNT ligand secretion inhibitor

I

Advanced solid tumors (in expansion)

A Phase I Trial of Bevacizumab, Temsirolimus Alone and in Combination With Valproic Acid, or Cetuximab in Patients With Advanced Malignancy and Other Indications

Texas

Drug(s) in Trial	Other Drug Names	Main Known Action
Bevacizumab	immunoglobulin G1 (human-mouse monoclonal rhuMab-VEGF gamma-chain, anti-VEGF monoclonal antibody, Avastin	VEGF antagonist
Cetuximab	Erbitux, Anti-EGFR Monoclonal Antibody, Chimeric MoAb C225	EGFR antagonist
Temsirolimus	CCI-779, Torisel	mTOR inhibitor
Valproic acid	Depacon, Depakene, Stavzor, Valproate	HDAC and NOS inhibitor

I

Advanced solid tumors with FGF/FGFR alterations (in expansion)

Phase 1/2 Study of TAS-120 in Patients With Advanced Solid Tumors Harboring FGF/FGFR Aberrations

Arizona, California, Florida, Georgia, Illinois, Kansas, Massachusetts, Michigan, Minnesota, New Mexico, New York, Pennsylvania, South Carolina, Texas, Washington, Wisconsin

Drug(s) in Trial	Other Drug Names	Main Known Action
TAS-120	FGFR inhibitor TAS-120	FGFR1-4 inhibitor

I

Advanced solid tumors

A Phase I Trial of Dasatinib (PDGFR and SRC Inhibitor), Temsirolimus and Cyclophosphamide in Patients With Advanced Solid Tumors

Texas

Drug(s) in Trial	Other Drug Names	Main Known Action
Cyclophosphamide	Ciclofosfamida, Ciclofosfamide, Claphene, CP monohydrate, CPM, Cyclophospham, Cyclophosphamid monohydrate, Cyclophosphamidum, Cyclophosphan, Cyclophosphanum, Cytophosphane, Mitoxan, Syklofosfamid, Zytoxan, Clafen, Cytoxan, Neosar, Carloxan, Cicloxal, Cycloblastin, Cycloblastine, CYCLO-cell, Cyclostin, Cyclostine, Cytophosphan, Endoxan, Endoxana, Enduxan, Fosfaseron, Genoxal, Ledoxina, Procytox, Sendoxan	DNA damaging agent
Dasatinib	BMS-354825, Sprycel	SRC and bcr-abl kinase inhibitor
Temsirolimus	CCI-779, Torisel	mTOR inhibitor

I

Advanced EphA2+ solid tumors (in expansion)

EphA2 Gene Targeting Using Neutral Liposomal Small Interfering RNA Delivery (IND# 72924): A Phase I Clinical Trial

Texas

Drug(s) in Trial	Other Drug Names	Main Known Action
siRNA-EphA2-DOPC		EphA2 inhibitor

I

Advanced solid tumors

A Phase 1 Trial of the Combination of the Heat Shock Protein-90 (HSP90) Inhibitor Onalespib (AT13387) and the Cyclin-Dependent Kinase (CDK) Inhibitor AT7519M in Patients With Advanced Solid Tumors

District of Columbia, Maryland, Massachusetts, Ohio

Drug(s) in Trial	Other Drug Names	Main Known Action
AT13387	Hsp90 inhibitor AT13387	Hsp90 inhibitor
AT7519	cyclin-dependent kinase inhibitor AT7519, CDKI AT7519	CDK1, 2, 4, 6, 9 inhibitor

I

Advanced solid tumors (in expansion)

A Phase 1 Multicenter, Open-label, Dose-escalation and Dose-expansion Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Immunogenicity, and Antitumor Activity of MEDI9447 Alone and in Combination With MEDI4736 in Adult Subjects With Select Advanced Solid Tumors

California, Connecticut, Florida, Georgia, Missouri, North Carolina, Ohio, Tennessee, Texas

Drug(s) in Trial	Other Drug Names	Main Known Action
Durvalumab	Anti-B7H1 Monoclonal Antibody MEDI4736, MEDI4736, Imfinzi	Blocks PD-L1 inhibition of T cells
Oleclumab	anti-CD73 monoclonal antibody MEDI9447	Blocks Ecto-5-nucleotidase (CD73) inhibition of T cells

I

Advanced solid tumors (inc expansion)

A Phase I Trial of Ipilimumab (Immunotherapy) and MGN1703 (TLR Agonist) in Patients With Advanced Solid Malignancies

Texas

Drug(s) in Trial	Other Drug Names	Main Known Action
Ipilimumab	Anti-Cytotoxic T-Lymphocyte-Associated Antigen-4 Monoclonal Antibody, MDX-010, Yervoy	Blocks CTLA-4 inhibition of T cells
MGN1703	TLR9 agonist MGN1703	TLR9 agonist and immune cell activator

I

Recurrent or persistent ovarian cancer