| NCT05445778 | III | High grade serous FRalpha high+ ovarian cancer with platinum-sensitive recurrence and CR, PR or SD after second line platinum-based therapy, must have avastin with most recent platinum-based therapy (maintenance) | Randomized, Multicenter, Open-label, Phase 3 Study of Mirvetuximab Soravtansine in Combination With Bevacizumab Versus Bevacizumab Alone as Maintenance Therapy for Patients With FRα-high Recurrent Platinum-sensitive Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancers Who Have Not Progressed After Second Line Platinum-based Chemotherapy Plus Bevacizumab (GLORIOSA) | AL, AZ, CA, FL, GA, IL, IN, IA, KS, KY, LA, ME, MD, MA, MI, MN, NE, NV, NH, NJ, NY, NC, OH, OK, OR, PA, SD, TN, TX, VA, WA | View Drugs | View Results |
Bevacizumab | immunoglobulin G1 (human-mouse monoclonal rhuMab-VEGF gamma-chain, anti-VEGF monoclonal antibody, Avastin | VEGF antagonist | Approved in Ovarian Cancer | Mirvetuximab soravtansine | M9346A-sulfo-SPDB-DM4, IMGN853, Anti-FOLR1-mab Maytansinoid Conjugate | ADC: anti-FRalpha + microtubule destabilizer (DM4) | Approved in Ovarian Cancer |
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| NCT06175221 | IIa | Stage I-IV solid tumors (fresh tumor available) | A Prospective, Open-Label, All-Comers Phase IIa Trial of The Tumor Lysate, Particle Only (TLPO) Cancer Vaccine in Solid Tumor Malignancies | SC | View Drugs | |
TLPO vaccine | | Immune response against tumor associated antigens | Clinical Trials |
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| NCT04804007 | II | Germ cell tumors after treatment with high-dose chemotherapy (HDCT) and peripheral-blood stem-cell transplant (PBSCT) (maintenance) | Randomized Phase 2 Trial of Maintenance Oral Etoposide or Observation Following High-dose Chemotherapy for Relapsed Metastatic Germ-Cell Tumor | IN | View Drugs | |
Etoposide | VePesid, Toposar, Lastet, epipodophyllotoxin | Topoisomerase II inhibitor | |
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| NCT05887609 | II | High grade serous or endometrioid FRalpha medium or high+ ovarian cancer with platinum-sensitive recurrence and CR, PR or SD after most recent platinum-based therapy; BRCA MUT patients must have received prior PARP inhibitor therapy (maintenance) | A Phase II Evaluation of Maintenance Therapy Combination Mirvetuximab Soravtansine and Olaparib in Recurrent Platinum Sensitive Ovarian, Peritoneal, and Fallopian Tube Cancer | CO | View Drugs | View Results |
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| NCT05726864 | I | Advanced solid tumors with KRAS G12A/C/D/R/S/V or KRAS G13D or NRAS G12C/D/R/S/V with presence of disease only detectable by circulating cDNA and/or elevated biomarker | First in Human Phase 1/2 Trial of ELI-002 7P Immunotherapy as Treatment for Subjects With Kirsten Rat Sarcoma (KRAS)/Neuroblastoma RAS Viral Oncogene Homolog (NRAS) Mutated Pancreatic Ductal Adenocarcinoma (PDAC) and Other Solid Tumors | AZ, CA, CO, FL, GA, IA, LA, MA, MI, MN, NY, PA, TN, TX, WI | View Drugs | |
ELI-002 7P | | Immune response against cancer expressing KRAS G12A/C/D/R/S/V or KRAS G13D or NRAS G12C/D/R/S/V | Clinical Trials |
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